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P Toseland

Publications and source records attributed to P Toseland.

6 recordsLinked to original sources
PubMed1984

Beer drinking and its effect on uric acid.

This study attempted to simulate the drinking habits of gout patients. Beer or squash was drunk over a 4-hour period on two successive days by five gouty and five normouricaemic men. Serum lactate increased with beer and squash, but elevation of plasma uric acid was confined to beer drinking. Urate clearance increased with both beverages, but 24-hour uric acid excretion was accentuated only by beer. The purine content of several beers was measured and the principal constituent found to be guanosine, which is probably the most readily absorbed dietary purine. It was concluded that the hyperuricaemic effect of beer was mediated by the digestion of purines contained by the beer and by an effect of ethanol on uric acid synthesis. There was no evidence that beer taken in usual quantities reduced the renal excretion of uric acid.

Alcohol Drinking↗
PubMed1982

Evaluation of a height/plasma creatinine formula in the measurement of glomerular filtration rate.

The clinical usefulness of the quantity height (cm)/plasma creatinine (Ht/Pcr) as a predictor of glomerular filtration rate (GFR) was investigated in 163 children with varying levels of renal function. Plasma creatinine levels (mumol/l) were measured by an automated reaction rate method. The results indicate that in rather more than half the children studied, an estimate of GFR adequate for ordinary clinical purposes will be obtained from Ht/Pcr, or from the derived formula GFR (ml/min per 1.73 m2) = 40 Ht/Pcr. The accuracy of the prediction is greatest in children with reduced function (GFR less than 80 ml/min per 1.73 m2) and in this group of patients a change of GFR of 19 ml/min per 1.73 m2 or more is reliably detected by this method. We conclude that Ht/Pcr is a clinically useful aid to the estimation of renal function, reducing the need for formal GFR measurements by at least half.

Adolescent↗