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Biomedical subjects

P Toto

Publications and source records attributed to P Toto.

7 recordsLinked to original sources
PubMed1989

Cytokeratins in hamster cheek pouch epithelium during DMBA-induced carcinogenesis.

The pattern of keratin expression in hamster cheek pouch epithelium during 15-wk of DMBA-induced carcinogenesis was studied. The sequential changes in cytokeratins of premalignant and malignant tissues and comparative investigation of normal epithelial tissues were examined during a weekly sequential DMBA-induced chemical carcinogenesis. Keratin polypeptides of normal pouch epithelium appear in a molecular weight range of 43-67 kd and 5-6 proteins can be identified. The disappearance of high molecular weight keratin (61-67 kd) was observed from the 6-wk DMBA-treated premalignant group to the 15-wk DMBA-treated malignant group. An additional keratin polypeptide was noted initially on the 11th-wk-DMBA-treated group and remained to the 15th-wk-DMBA treated group.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1978

Immunotherapy of chemically-induced tumors in the hamster cheek pouch with dinitrochlorobenzene.

Immune stimulation with an agent such as dinitrochlorobenzene (DNCB) may delay chemical carcinogenesis. Dimethylbenzanthracene (DMBA) was used to chemically induce tumors in the hamster buccal pouch. Hamsters were studied for the effect of DNCB sensitization in the buccal pouch prior to or after DMBA tumor induction. At appropriate time intervals the hamsters were sacrificed and each cheek pouch was examined histologically for the development of DMBA-induced tumors and for the presence of lymphoid cells infiltrating the tumor site. The results show that DNCB immunotherapy or immunoprophylaxis prior to or following DMBA tumor induction can alter the type of tumor produced and stimulate an infiltration of lymphoid cells into the tumor area probably invoking immune defense mechanisms.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1977

Delayed hypersensitivity in the hamster cheek pouch.

A method is described for eliciting a delayed hypersensitive cell mediated immune response in the Syrian hamster cheek pouch. Using a sensitizing dose of 0.1% DNCB and a challenge dose of 0.01% DNCB 14 days later resulted in a histologically positive lymphocyte infiltrate in the challenge area. These results indicate that the hamster cheek pouch may not be an immunologically inert site and may be used for cell mediated immunity studies.

Animals↗
PubMed1975

Osseous coagulum: a histologic evaluation.

Chronic periodontitis can be successfully simulated in primates by the method employed in this study. Osseous defects can be created with a marked degree of similarity to one another and subsequently rendered into chronic lesions for healing-repair studies. The chronic periodontal ossious defects corrected by the osseous coagulum technique and by curettage in the rhesus monkey in this study were repaired by the regeneration of the architecture of the lost tissue. The use of the osseous coagulum in two- and three-walled periodontal osseous defects led to a more rapid osteogenesis in such defects as compared to correction by curettage alone. This rapid filling of the osseous defects may serve to inhibit the apical migration of the epithelial attachment during the early stages of repair, and thereby inhibit a subsequent recurrence of the defect. Clinically and histologically, no readily apparent distinction could be made in the healing process between the two- and three-walled lesions.

Alveolar Process↗