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Biomedical subjects

P Tripathi

Publications and source records attributed to P Tripathi.

18 recordsLinked to original sources
PubMed1995

Antioxidant and anti-inflammatory property of Sandhika: a compound herbal drug.

The present study was envisaged to assess the rationality for the use of "Sandhika", a popular Ayurvedic drug in rheumatoid arthritis. This drug, when tested against carrageenan induced paw oedema and cotton pellet granuloma, showed significant anti-inflammatory activity at the dose of 0.25 g/kg body weight. The antioxidant property was assessed by determining cumene hydroperoxide (CHP) induced lipid peroxidation and reduced glutathione content in rat liver homogenate (in vitro). Experiments show the significant protection against lipid peroxidation at the dose of 80 micrograms/ml, measured as reduction in the level of malondialdehyde (MDA) induced by 1.5 mM cumene hydroperoxide (CHP). This effect was accompanied by the maintained reduced glutathione (GSH) content in drug treated rats. Oral treatment of drug up to 2 g/kg body weight for 15 days did not show any rise in serum transaminases (SGOT and SGPT). The results suggest that "Sandhika" which is an indigenous drug for inflammation with no detectable adverse effect, might be acting through scavenging the free radicals.

Animals↗
PubMed1992

Reassessing the status of antiphospholipid syndrome in systemic lupus erythematosus.

The antiphospholipid syndrome was initially described in 1986. To reassess the validity of antiphospholipid antibodies in systemic lupus erythematosus (SLE), 95 patients with SLE were studied. Their antiphospholipid antibody profile was analysed and correlated with clinical findings such as thrombosis, abortions, or thrombocytopenia. A low prevalence of these antibodies was found (13 patients; 14%) with a high specificity for thrombosis (92%) and abortions (92%). The importance of anticardiolipin antibodies as a risk factor for thrombosis or abortions, or both, in patients with SLE is reaffirmed by this work.

Abortion, Spontaneous↗
PubMed1990

The effect of the chewing side on parotid amylase secretion in conscious rabbits.

This study was conducted to investigate whether changes in amylase output accompany changes in salivary flow which occur during feeding. New Zealand White rabbits were trained to eat food offered to them in the laboratory. After chronic parotid duct cannulation, saliva was collected and flow rates recorded bilaterally while the animals fed on fresh carrots or pelleted food. The amylase concentration (U/ml) obtained with carrots was greater than with pellets, but because of the differences in flow rate, the overall amylase output (U/min) for both foods did not differ. There was no difference in the amylase concentration in saliva collected either ipsilateral to or contralateral to the chewing side. However, amylase output was significantly greater ipsilateral than contralateral to chewing with both pellets (p less than 0.01) and carrots (p less than 0.05).

Amylases↗
PubMed1987

Choledochus cyst.

Explore the source record for details and available documents.

Adolescent↗
PubMed1980

Study of the effect of amines on structure of coacervates formed by photochemical effect on metal ions in presence of formaldehyde.

If an aqueous mixture of ammonium molybdate, diammonium hydrogen phosphate, biological minerals, and formaldehyde is exposed to sunlight, typical "Jeewanu", mixtures are observed. However, if a little solution of p-phenylene diamine, p-nitroaniline, alpha-naphthylamine or beta-naphthyl amine is added to it, a dense white precipitate is obtained. This precipitate, under a microscope at X1200 magnification, appears as large clusters of very tiny cream-coloured spherules. But if the mixture is first exposed to sunlight for four hours, when the formation of typical microstructures appears, and then the amine solution is added, the formation of the precipitate is retarded as the exposure time of amine-free mixture is enhanced, till finally the formation of spherules as precipitate is stopped. Microscopic study in twenty days of exposure of the amine-containing mixture tube shows that the number of typical microstructures decreases; they get larger in size and gradually disintegrate, while the formation of tiny sdpherules is accelerated.

1-Naphthylamine↗
PubMed1980

Detergent effect on metabolic changes in microorganisms. A review.

Detergents contain a hydrophobic hydrocarbon structure and a hydrophilic group which may be anionic, cationic, or neutral. Detergents form stable emulsions and are capable of trapping lipid-soluble materials in the interior of the hydrophobic portion of the miscelles. Application of the knowledge of detergents to the discipline of microbiology would provide interesting and accurate data for further studies.

Bacteria↗
PubMed1980

Organic acids produced by self-sustaining coacervates in presence of p-nitroaniline and p-phenylene-diamine.

Oleic and malonic acids were found in control samples while p-nitroaniline addition induced production of tricarballylic acid in eight and twelve days exposed samples. Fumaric and citric acids were found in sporadic instances. Addition of p-phenylene diamine to the mixture showed a degeneration process in organic acid production. In some cases production of fumaric acid was positive.

Aniline Compounds↗
PubMed1979

Investigation of effect of alpha-naphthylamine and beta-naphthylamine on organic acids formation of self-sustaining coacervates.

Malonic and oleic acids were found in the typical mixtures. Samples containing alpha-naphthylamine gave oleic and malic acids which disintegrated with time of exposure. Tricarballylic acid was confirmed in presence of beta-naphthyl amine, but disappeared with time. Arachidic, tartaric, and adipic acids were found, but they disappeared in eight days' exposed samples. At later stages of exposure, malonic acid was observed along with sporadic appearances of citric , succinic, and oleic acids. Rate of disintegration of these compounds was directly proportional to time of exposure to sunlight.

1-Naphthylamine↗
PubMed1979

Amino acid changes in abiogenic mixtures containing p-nitroaniline and p-phenylene diamine.

Mixtures containing diammonium hydrogen phosphate, ammonium molybdate, and minerals in presence of p-nitroaniline resulted in formation of glycine, methionine, phenylalanine, tryptophan, and tyrosine. Proline and valine were observed in a few tubes. When p-phenylene diamine was present in the mixture, glycine was absent, while isoleucine and leucine were observed in the tubes. Predominance of proline was observed in all the studies executed.

Amino Acids↗
PubMed1978

Investigation of cerium and yttrium ions effects on microbial nitrogen fixation and determination of inhibition.

Critical investigation of the effect of yttrium and cerium ions in culture media for nitrogen-fixing bacteria showed strong inhibition. There was a decrease in the amount of nitrogen fixed; simultaneously, in the samples containing cerium ions, carbon consumption values increased as the molarity of metal ion was enhanced. Inhibition rate was invariably maximum at the highest concentration of metal ions.

Bacteria↗
PubMed1978

Investigation of amino acid changes in self-sustaining coacervates in presence of alpha-naphthyl amine and beta-naphthyl amine.

Pronounced variation of amino acids was exhibited. Phenylalanine and tryptophan were invariably present, except at very few exposure periods. Methionine was perceived in many studies in alpha-naphthylamine, while in the study of beta-naphthylamine it was observed at four days' exposure. alpha-Naphthylamine produced cysteine along with tyrosine, leucine, isoleucine, and norleucine, while beta-naphthylamine gave valine along with tyrosine, leucine, isoleucine, and norleucine. Complete variation from blank signifies the effect of alpha- and beta-naphthyl amine on the mixture.

1-Naphthylamine↗
PubMedDate not supplied

Assessment of the adrenergic beta-blocking activity of Inula racemosa.

Inula racemosa root powder was investigated in patients with proven ischaemic heart disease. The powder prevented ST-segment depression and T-wave inversion as observed in the post-exercise electrocardiogram. The petroleum ether extract of roots lowered plasma insulin and glucose levels within 75 min of oral administration to albino rats and it significantly counteracted adrenaline-induced hyperglycaemia in rats. The extract further showed negative inotropic and negative chronotropic effects on frog heart. All these findings indicate that one of the constituents of Inula racemosa may have adrenergic beta-blocking activity.

Adrenergic beta-Antagonists↗