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Biomedical subjects

P Troufléau

Publications and source records attributed to P Troufléau.

12 recordsLinked to original sources

[MR imaging findings of bone marrow reconversion induced by growth factors in 3 patients].

MRI is now the method of choice for bone marrow imaging. The MR appearance of bone marrow is influenced by the relative amounts of its fatty or hematopoietic components. In the following study, we report different patterns in changes consistent with reconversion into hematopoietic tissue of fatty marrow that were observed in 3 patients who received hematopoietic growth factors in combination with their chemotherapy for musculo-skeletal tumors of lower limbs.

Adult↗

[3D reconstruction of microcalcification clusters].

PURPOSE: A characterization of the geometrical or morphological aspect of microcalcifications is not sufficient to confirm a diagnosis of cancer. On the other hand, it seems that the shape of the cluster is a pertinent and helpful criterion for diagnosis. The aim of our study is to work out a method for 3D reconstructions of clusters of microcalcifications. MATERIALS AND METHODS: After having tested different algorithms for extracting microcalcifications, we have developed a method of 3D reconstructions of the shape of the cluster from three radiographs. The technique, available using a standard mammography unit, consists of three principal steps RESULTS: The technique has been tested with two simple tridimensional phantoms and has given results with sufficient precision for possible clinical use. CONCLUSION: We plan now to apply the method in vivo with adaptation on a dedicated mammographic stereotactic unit with digital acquisition.

Algorithms↗

[CT and MR imaging of a solitary fibrous tumor of the thigh].

Solitary fibrous tumor is a rare mesenchymal tumor usually involving the pleura. Extrapleural lesions may also occur. We report the CT and MRI appearance of a solitary fibrous tumor of the thigh. The imaging features as well as the histological and immunohistochemical characteristics are presented, especially its reactivity to the CD34 antigen. The tumor is most often benign, particularly in extra-pleural location, with good prognosis after total resection. Imaging is mainly useful to locate the tumor and assess its extension prior to surgery.

Humans↗

[Image quality and optical density in mammography: study on phantoms].

Optical densisty (od) is an important factor for image quality in mammography. We studied the effect of o.d. on the image score with two phantoms (Contrast Detail MAMmography phantom (CDMAM), University Hospital Nijmegen, The Netherlands and breast-equivalent phantom (MTM 100) made by CIRS in the United States). We also evaluated the doses required to obtain the blackening considered from measurements made with thermoluminescent pastilles. Two series of exposure were performed at 28 kV with mAs ranging from 25 to 100 to obtain a range of o.d. varying between 0.72 and 2.67. Image scores were then evaluated for each negative by calculating the mean of five different readers. The study showed a clear increase of the image score with o.d. These observations were consistent with other studies. For the two phantoms and the screen-film combination used, the maximum quality was obtained for an o.d. of 1.6, but the drawback of negatives at high o.d. is increase of the irradiation dose from 5,4 to 7,2 mGy when the o.d. increases from 1.30 to 1.70.

Artifacts↗

[Ductal carcinoma in situ of the breast: role of imaging].

The incidence of ductal carcinoma in situ (DCIS) has increased with the widespread use of screening mammography. DCIS is often suspected when clustered microcalcifications are evidenced on routinely performed mammography. High quality mammographies are required and should be completed with magnification views. Mammographic--pathologic correlations are described according to the new classifications as well as unusual forms of presentation on mammography. Early contrast enhancement in DCIS on dynamic MRI is reported and seems to be related with angiogenesis. A wire localization procedure of non-palpable lesions has to be performed and per-operative specimen radiography is mandatory. Stereotaxic large core needle biopsy is a valuable alternative to surgical biopsy but a multidisciplinary team approach is necessary and follow-up is recommended if no excisional biopsy is done. Quality in the management of DCIS depends on the coherence of the "multidisciplinary team".

Biopsy↗

Primary low-grade B-cell lymphoma of MALT-type occurring in the liver: a study of two cases.

BACKGROUND/METHODS: Primary non-Hodgkin's lymphomas of the liver are rare. One specific clinico-pathological entity has been identified as hepatosplenic gamma/delta T-cell lymphoma. Recently, another distinct primary lymphoma of the liver has been recognised as primary low-grade hepatic B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), based on a study comprising four cases. We analysed two additional cases of this particular non-Hodgkin's lymphoma, not only by morphology and phenotyping, but also by genotyping and cytogenetic analysis. RESULTS: This type of non-Hodgkin's lymphoma is characterised by a dense lymphoid infiltrate, localised in the portal tracts, and is associated with lympho-epithelial lesions of the bile ducts, thereby mimicking hepatitis or an inflammatory bile duct disorder. In one of our cases, translocation t(3;14)(q27;q32) was identified as the sole cytogenetic abnormality. A high incidence of trisomy 3 has been associated with marginal zone B-cell lymphomas, and fluorescence in situ hybridisation as well as comparative genomic hybridisation studies have shown frequent involvement of the long arm of chromosome 3. Nevertheless, t(3;14)(q27;q32) involving BCL6 gene, located at 3q27, has not yet been found. CONCLUSION: Our findings suggest a role for the BCL6 gene in the histogenesis of this particular lymphoma.

Antigens, CD↗

[Mesenteric panniculitis. Aspects in x-ray computed tomography and MRI].

We report one case of mesenteric panniculitis. This rare and poorly-known disease is characterized by a non specific inflammatory process involving adipose tissue of the mesentery. The new imaging techniques (CT and MRI) may be helpful for the diagnosis of this disease and allow avoiding laparotomy. However histological proof remains necessary and can be given by guided needle biopsy.

Humans↗

[Current role of x-ray computed tomographic test in the detection of lesions of peritoneal carcinomatosis].

CT scan is presently the method of choice in the pre-operative evaluation of patients with peritoneal carcinomatosis. The aim of this article is to present the results of a personal work concerning the comparison of CT scan and the surgical data in the diagnosis of peritoneal carcinomatosis and to compare them with data of the literature. Despite the existence of unavoidable bias related to the retrospective characteristic of the study, the results confirm the good sensitivity of the scan in the examination of peritoneal carcinomatosis, through it remains insufficient to do without surgical exploration.

Adolescent↗

[Pharyngolaryngeal tumors: spiral X-ray computed tomography with 3-dimensional reconstruction].

Spiral CT allows the exploration of the whole larynx and hypopharynx in 30 seconds. This is a good adjustment between the technique and the organ. Performed on 15 patients during a 30 seconds' Valsalva maneuver, the exploration yields results from good to excellent. In two cases, conventional and helical CT are compared. The limitation of mA is not a drawback in such a thin region and there is no shift of organ or lesion between two scans, because the whole range is scanned in a single breathhold. 3D display of larynx and pharynx can be performed with some advantage, especially easiness of presentation for surgeon. They help topographic analysis and make correlation between endoscopic views and axial scans. They could be useful for surgical simulation and 3D photon treatment plannings.

Feasibility Studies↗