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P Tyson

Publications and source records attributed to P Tyson.

At least 19 recordsLinked to original sources
PubMed2007

Use of the recto-sigmoid index to diagnose Hirschsprung's disease.

The recto-sigmoid index on barium enema may aid in the diagnosis of Hirschsprung's disease. However, data on its reliability in different age groups are sparse. The recto-sigmoid index and transitional zone were evaluated blindly in 107 patients with diagnostic rectal suction biopsies. Patients were divided into 3 groups: neonates, infants older than 1 month, and children. The recto-sigmoid index and transitional zone agreed with the histopathologic diagnosis in 79% and 87% of the cases, respectively. Their negative predictive values reached clinical significance in infants and children but not in neonates. Their positive predictive values were not significant in any age group. The recto-sigmoid index identified 4 patients with recto-sigmoid Hirschsprung's disease whose diagnosis was missed by evaluating the transitional zone alone.

Adolescent↗
PubMed2000

Sequence variation within the RPGR gene: evidence for a founder complex allele.

In our study of sequence variation within the RPGR gene associated with X-linked retinitis pigmentosa, we and others have observed a high rate of new mutation within this gene, as all reported mutations are unique or uncommon. In this article we report the identification in a single family of a complex allele of 7 sequence variants in linkage disequilibrium, of which four result in amino-acid alterations (Arg425Lys, DGlu, Thr533Met and Gly566Glu). This complex allele was initially found in a family with XLRP. However, further study revealed an estimated prevalence of 4.3% (15/344 chromosomes) with this complex allele in the European population indicating the non-pathogenic nature of this allele and, along with previously reported polymorphisms, further supporting a high level of human protein diversity for RPGR. This common complex allele may have been established in the population as a founder effect. Complete gene sequencing identified a potential pathogenic sequence variant in the family described (IVS6+5G>A). This study emphasises the need to create a more complete picture of the allelic variation within a gene, suggests cautious interpretation of a phenotypic association with variant sequences, and highlights the potential problems associated with interpreting genetic studies for diagnostic purposes.

Alleles↗
PubMed1996

Object relations, affect management, and psychic structure formation. The concept of object constancy.

Object relations are central to contemporary structural theory. This paper first reviews the various ways in which the key concept object constancy has been used. To reconcile the apparent contradictions in definitions, the concept is viewed along a developmental continuum in which each step is defined by its functions. It is proposed that at its most mature stage, a capacity for affective self-regulation is achieved, a capacity that is central to characterological structure formation and optimal adaptation. Possible interferences with the achievement of mature object constancy are briefly explored.

Adolescent↗
PubMed1996

Neurosis in childhood and in psychoanalysis: a developmental reformulation.

It is widely believed that the transference neurosis, understood as both a repetition of the infantile neurosis, and as an opportunity for new forms of object relations, is the hallmark of psychoanalysis. Because the concept has become caught up in such polemics over the years and has acquired such a variety of meanings, some call for its abandonment; some also call for abandoning the concept of the infantile neurosis. This paper argues that both these concepts refer to significant clinical phenomena and so rather than being abandoned, they should be clarified and redefined in the light of contemporary developmental theory.

Child↗
PubMed1996

A classic revisited: Loewald on the therapeutic action of psychoanalysis.

Versions of the following papers were presented at the panel "Psychoanalytic Classics Revisited: Hans Loewald's "On the Therapeutic Action of Psychoanalysis' " (Gerald I. Fogel, chair) at the meetings of the American Psychoanalytic Association, December 1993. As a tribute to Loewald's lifetime of achievement, and in belated recognition of his preeminent position in the field of psychoanalysis, the exchange appears here almost in its entirety, rather than as a conventional panel report.

History, 20th Century↗
PubMed1994

Bedrock and beyond: an examination of the clinical utility of contemporary theories of female psychology.

Libido theory and the idea of an innate matrix of bisexuality are an inadequate basis on which to understand female psychology. Rather, it is the mutual influence of sexuality, aggression, object relations, and a superego that inherits the object-related conflicts of early childhood, intertwined as these are with gender issues, that determine the way a woman experiences herself. A woman can have a basically confident, narcissistically valued sense of femaleness and at the same time be troubled by intense feelings of inadequacy and deprivation. Instead of arbitrarily attributing these feelings to penis envy and a sense of castration, based on the idea of bisexuality as bedrock, this paper suggests that we consider primary femininity as bedrock, but that the superego, as heir to unresolved preoedipal and oedipal object-related conflicts, functions to maintain these painful emotions. Clinical material illustrates the utility of these ideas.

Adult↗
PubMed1989

Infantile sexuality, gender identity, and obstacles to oedipal progression.

Contrary to when it was first proposed, infantile sexuality nowadays is accepted as an important part of child development. However, Freud's views on masculine primacy and feminine inferiority are seen to be incomplete and inaccurate not only because they over-emphasize sexuality and sexual anatomy, but also because they neglect aggression, object relations, ego and superego functioning, and the sense of self. Infantile sexuality is therefore reconsidered within the broader perspective of gender identity. Within this broader perspective, normal and aberrant sexual development is discussed, and new ideas are offered about familiar concepts such as castration anxiety and penis envy.

Child↗
PubMed1986

Male gender identity: early developmental roots.

The purpose of this paper has been to bring together a wide variety of ideas about male gender and sexual development into a broader and updated view. Toward that end, I have suggested that we view the concept of gender identity along three intertwining strands; core gender identity, gender role identity, and choice of love object. I have also suggested some important contributions made to each of these strands at various phases of development. I have concentrated upon the early childhood roots of gender identity, particularly as the earliest years are the time when important internal structures are established and consolidated. Later manifestations, although not the same as the early ones, have their roots in the early childhood configurations. However, the contributions to an overall broad sense of gender identity made during the latency and adolescent years must not be overlooked. The final outcome of any position along any of the strands is not finally consolidated until the end of adolescence. Indeed, adult experiences may also make important contributions.

Adult↗
PubMed1984

Narcissism and superego development.

To elucidate the role of the superego in th maintenance of narcissistic equilibrium, we reviewed Freud's ideas about narcissism and the superego as well as the relevant theories of Kohut, Kernberg, and certain ego psychologists. These latter authors offer an alternative mode of understanding narcissism more consistent with Freud's structural theory, one in which signal affects and superego functioning play a central role in normal development and in the pathogenesis of narcissistic disturbances. Early steps in superego formation were then examined schematically to elucidate the interaction of environmental influences and emerging psychic structure. We suggested that the first step in a developmental line toward superego formation is based on the affective qualities experienced in the course of self-object differentiation. Subsequent steps examined were introject and ego-ideal formation; compliance with th object; compliance with the introject; identification with the introject and the ego ideal; and finally, with oedipal resolution, the integration of superego nuclei into a progressively structuralized autonomous superego system. This system achieves growing independence from the drives and from pressures from early introjects during the course of latency, and functions to maintain the demands of the conscience and the standards of the ego ideal; rewards or punishments result when these demands and standards are or are not met. The final stage briefly considered here was the revision, modification, and elaboration of moral codes and the ego ideal as part of the adolescent process. Narcissistic vulnerabilities at various stages were pointed out in an attempt to stress that a particular clinical picture in later phases of development or adulthood may derive from any of several development points of origin and from one or more etiological factors.

Aggression↗
PubMed1982

A developmental line of gender identity, gender role, and choice of love object.

A schematic overview of the development of male and female gender identity has been presented with an attempt to formulate a developmental line. The steps include: (Table: see text) In discussion of these steps an effort was made to distinguish between core morphological or core gender identity--that is, the primary sense of being male or female, to which other aspects of gender identity are added over the course of development to eventually include a "mix" of masculinity and femininity; gender role identity, which includes the conscious and unconscious mental representations of dialogues with other people vis-à-vis one's gender identity as well as identification with role models; and the separate process of choosing a sexual partner orientation. These separate strands join together and intermingle to make up what we view globally as "gender identity."

Adolescent↗
PubMed1982

A case of 'pseudo-narcissistic' psychopathology: a re-examination of the developmental role of the superego.

In this paper we have attempted a tentative delineation of particular superego elements which may be involved in the production of 'pseudo-narcissistic' psychopathology, that is to say, a disturbance which superficially appears to be a narcissistic personality disturbance but which is fundamentally based on neurotic conflict. Using a framework of superego constituents and superego functions, aspects from the analysis of a man with profound difficulties in self-esteem regulation were examined to highlight his intrasystemic conflict--a conflict of ideals. Some possible explanations were offered, taking into account the persistence of early stages in the development of the superego and of difficulties in the resolution of oedipal conflicts. This work is offered as an example of a way in which the psychoanalytic treatment process can contribute to knowledge of early psychic structure formation and development.

Adult↗