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P V Lippolis

Publications and source records attributed to P V Lippolis.

26 records · Page 2Linked to original sources
PubMed1993

[Treatment of hyperfunctioning thyroid adenoma: current trends].

Thyroid adenoma is commonly associated with surgery and radiometabolic treatment; recently, according to previous successful reports, percutaneous ethanol injection therapy under sonographic guidance, has been introduced as an alternative. This technique has already been favourably used in the treatment of focal lesions, such as liver cancer and hyperparathyroidism. In our experience, we have treated with such therapy 69 patients affected by thyroid adenoma (55 females, 14 males; 28 pretoxic, 41 toxic). Ethanol (0.5-2.8 mL/mL nodular tissue) was injected, under sonographic guidance, in 4-9 sessions (1 weekly). Thyroid hormone profile was assessed during treatment and at 3 and 6 months follow-up. Apart from local transient pain in 21% sessions, two cases of pyrexia (38.5 degrees-1 day) and 3 cases of transient dysphonia, no relevant adverse effects were observed. A slight thyroid hormone increase was seen in both groups immediately following treatment. Six months after therapy a biochemical and clinical remission of hyperthyroidism was observed in 33 out of 41 toxic patients (80%); a significant increase of TSH levels was seen in both groups (p < 0.001). With follow-up, significant volume shrinkage (70-80% volume reduction--p < 0.0001) as well as structural alterations of the nodule, were consistently recorded at sonography, in both groups; a linear relationship (p < 0.0001) between pretreatment volume and volume reduction was found. At scintiscan functional activity of extranodular parenchyma was found in 75% of patients affected by pretoxic adenoma and in 63.1% of patients with toxic adenoma. These data confirm that percutaneous ethanol injection therapy is effective in obtaining functional ablation and in inducing remission of hyperthyroidism, when present; so it represents a valid and safe alternative to standard therapeutic tools of thyroid adenoma.

Adenoma↗
PubMed1993

[Echo-guided percutaneous alcohol injections of cold non-neoplastic thyroid nodules. Preliminary experience].

Percutaneous ethanol injection (PEI) has been recently used with excellent results to treat toxic and pretoxic thyroid adenomas. We investigated PEI efficacy also in the treatment of "cold" thyroid nodules in 31 patients with nodular goiter. All nodules were proved to be cold on thyroid scintigraphy. There was no clinical or cytologic suspicion of cancer. Informed consent to the experimental study was always obtained. Each patient received 24 +/- 4.1 ml of ethanol, injected once or twice a week. No significant side-effects were observed during treatment. All nodules shrank 66-97.6% (mean: 85.5%, p < 0.001 vs pretreatment volume). US-guided cytologic sampling was repeated at 3 months' follow-up. PEI was precautionally repeated in 4 patients exhibiting sparse follicular cells. Further data about this group are not available yet. These preliminary results prove PEI to be an effective and safe technique to treat thyroid nodules and to make a valuable alternative to surgery and L-thyroxine.

Adolescent↗
PubMed1992

[Ultrasonic diagnosis of gastroduodenal perforation].

Ultrasonography (US) is routinely used as a diagnostic approach in the surgical acute abdomen, even though its major limitation is the demonstration of the hollow viscus. In the present paper, the results obtained with US in 12 cases of gastric or duodenal perforations are reported. The diagnosis, of gastroduodenal perforation was correctly made in 58% of cases by means of US; in 91.7% of cases, at least one US finding correlable with gastroduodenal perforation was observed. Even though US exhibits poorer diagnostic sensitivity than conventional radiology, it can be considered a valuable diagnostic tool in the early diagnosis of gastroduodenal perforation especially when radiographic findings are negative.

Adult↗
PubMedDate not supplied

Cold thyroid nodules: a new application of percutaneous ethanol injection treatment.

Sonographically guided percutaneous ethanol injection (PEI) has been recently used with excellent results in the treatment of toxic and pretoxic thyroid adenoma. The aim of the present study was to assess the efficacy of PEI also in the treatment of "cold" thyroid nodules. Twenty patients, each with a single thyroid nodule, underwent PEI. In all cases the nodules were found to be cold by thyroid scintiscan. A total of 16.1 mL +/- 3.1 mL of ethanol was injected once a week. No adverse effects were observed during therapy. A striking nodular shrinkage was obtained in all cases, ranging from 72.8% to 97.6% (mean 84.5%, p < 0.001 vs pretreatment volume). These preliminary results suggest that PEI is an effective and safe therapy that may be useful in the treatment of thyroid nodules as an alternative to other therapies (surgery, L-thyroxine).

Adolescent↗
PubMedDate not supplied

Percutaneous ethanol injection treatment of autonomously functioning single thyroid nodules: optimization of treatment and short term outcome.

Twenty-five patients with solitary autonomous thyroid nodules (15 nontoxic, 10 toxic) received percutaneous ethanol injection treatment (PEIT) under sonographic guidance in 4-7 sessions (1-2 weekly). To test different doses, smaller nodules (volume less than 15 mL) were given 0.75-2.8 mL ethanol/mL nodular tissue while larger nodules received 0.5-1 mL/mL. Except for 1 patient who developed hyperpyrexia, no relevant adverse effects were observed. A slight, asymptomatic increase in serum thyroid hormone levels was observed in both groups during the treatment. Three months after treatment, a biochemical and clinical remission of hyperthyroidism was observed in 8 of 10 patients with toxic nodules. A significant increase of TSH level was seen in both groups (p less than 0.01). Significant shrinkage of volume (p less than 0.001) as well as structural alterations of nodules were consistently recorded at sonography. A linear relationship (r = 0.98; p less than 0.0001) between pretreatment volume and volume reduction was found both for large and small nodules, thus suggesting that even limited ethanol doses may be therapeutically effective. A recovery of extranodular parenchyma activity at scintiscan occurred in 16 (64%) of 25 patients. These data confirm that PEIT is effective in obtaining functional ablation and in inducing remission of hyperthyroidism. Adverse effects are infrequent. In spite of the small patient sample, a 0.5-1 mL ethanol dose per each mL of tissue appears as effective as larger doses and seems appropriate for treatment.

Drug Evaluation↗
PubMedDate not supplied

[Echography in the surgical emergency].

Abdominal sonography represents the diagnostic method of choice in case of acute abdomen. On the bases of their experience on more than 1200 consecutive examinations performed in case of acute abdomen the author evaluate the fields of application of sonography in acute patients. A decisional algorithm in trauma patients based on sonographic results is presented. The actual indications of sonography abdominal non traumatic pathology are presented: paying particular attention to acute gastro-intestinal diseases. The therapeutic role of interventional sonography in the acute abdomen is also discussed.

Abdomen↗