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Biomedical subjects

P V Mills

Publications and source records attributed to P V Mills.

15 recordsLinked to original sources
PubMed1990

Screening for hydroxychloroquine retinal toxicity: is it necessary?

All the patients (73) in the Rheumatology Department five year study of second line therapy who have taken hydroxychloroquine (Plaquenil) for rheumatoid arthritis for longer than 18 months were reviewed. These patients have their treatment dosage carefully monitored and have been receiving regular ophthalmic examinations. Most patients still taking the drug were assessed with a battery of tests for evidence of retinal toxicity. No retinal toxicity causing visual loss was found. On the basis of these results and a review of the recent literature we no longer routinely screen patients for hydroxychloroquine retinal toxicity in Cardiff.

Arthritis, Rheumatoid↗
PubMed1987

Loop recession of the recti muscles.

Scleral penetration with a suture needle is a well recognised risk of the surgical treatment of strabismus and may result in serious intra-ocular complications. The risk should be reduced by loop recession, a procedure derived from the adjustable suture technique. In practice in many cases this operation has also been found to have other advantages compared to a conventional recession. The surgical details of loop recession are described and the results obtained in 62 patients reviewed.

Adolescent↗
PubMed1983

Cyclosporin improves Graves' ophthalmopathy.

Cyclosporin given to two patients with Graves' ophthalmopathy produced a rapid objective improvement in both, including restoration of ocular-muscle function and visual acuity, improvement in exophthalmos, and reduction in orbital muscle swelling judged by computed tomographic scan. Thyroid autoantibody levels fell with treatment, and T-cell subset abnormalities returned towards normal. In one patient an absent thyrotropin response to thyrotropin-releasing hormone became normal after treatment. These results suggest that cyclospirin treatment should be considered in patients with the congestive ophthalmopathy of Graves' disease.

Acute Disease↗
PubMed1981

Assessment of the retinal toxicity of hydroxychloroquine.

A survey of 347 patients on treatment with hydroxychloroquine showed that a mild pigmentary maculopathy was present in 29 per cent of cases if a cumulative dose of more than 800 g of the drug had been ingested. Most of the affected patients showed no deterioration in visual function. The significance of these findings is discussed with particular regard to the screening of patients on hydroxychloroquine therapy.

Adult↗
PubMed1979

Preretinal macular fibrosis.

The clinical features of preretinal macular fibrosis are reviewed, particular consideration being given to related pathology at the vitreo-retinal interface. These observations are correlated with recent studies of the ultrastructural abnormalities present in this condition.

Adult↗
PubMed1967

Iridoschisis.

Explore the source record for details and available documents.

Aged↗
PubMedDate not supplied

Ocular assessment of patients treated with tamoxifen.

Tamoxifen is a specific estrogen antagonist used in the treatment of breast cancer. In a previous study, corneal and retinal changes were reported in four patients receiving high-dose tamoxifen therapy for greater than 1 year. Nineteen patients treated with tamoxifen for periods of 3 months to 4 years at normal dose levels have been studied and no ocular changes attributable to the drug were observed.

Aged↗