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Biomedical subjects

P Varkonyi

Publications and source records attributed to P Varkonyi.

3 recordsLinked to original sources
PubMed1990

Phenomenological kinetics of pharmacological response.

The evaluation and quantitative analysis of the time course of drug response are difficult tasks even in uncomplicated fields of pharmacology. In an attempt to assist the analysis of the pharmacological effect, a procedure is presented which incorporates widely used intuitive-experimental practices of evaluation, and descriptive kinetic functions. The aim is to find a simple function which can approximate the time course of the response curves at different doses. Having estimated the values of parameters for each curve, valuable information can be drawn by examining the dose-parameter relationships. The method is illustrated by one possible evaluation and interpretation of the blood pressure-time curves of a drug.

Animals↗
PubMed1986

Mathematical description of the interaction between prostaglandins and calcium.

The interpretation of the biological action of prostaglandins is very difficult because the shape of the dose-response curves in different assays is often unusual. Horrobin has attempted to explain these unusual curves by supposing special interactions between Ca and the prostaglandin receptors. This paper gives a mathematical description of his theoretical models. The results of computer simulation based on these models were in good agreement with the reported experimental observations.

Binding, Competitive↗