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Biomedical subjects

P Veraguth

Publications and source records attributed to P Veraguth.

At least 37 records · Page 2Linked to original sources
PubMed1979

Technical improvements in the clotted plasma droplet MIF assay in vitro.

The migration inhibitory activity of culture supernatants of rat and human lymphocytes stimulated with PHA and Con A-Sepharose was tested on cell migration from clotted plasma droplets. This technique was improved by using homologous as well as heterologous plasma and fibrinogen solutions for suspending the migratory cells, automatic micropipettes for performing the technique and purified cell populations as target. The effects of calcium chloride and of the cell concentration in the plasma droplets on the migration indices obtained in the MIF assay were tested.

Animals↗
PubMed1978

[Interdisciplinary treatment planning in cancer].

The prerequisites for and purpose of optimal interdisciplinary cooperation in cancer treatment planning are presented from the viewpoint of the medical oncologist, the surgeon and the therapeutic radiologists. Only with full appreciation of the therapeutic possibilities offered by each individual treatment modality and speciality can an optimal interdisciplinary treatment plan be devised. This maximum of cooperation and interdisciplinary teamwork is also the basis for further progress and improvement of therapeutic results.

Breast Neoplasms↗
PubMed1978

[Surgical and radiotherapeutic possibilities of treatment of mouth neoplasms].

The basic concept of the treatment of cancer of the oral cavity has not essentially changed in the past few decades. The final results depend mainly on the site and extent of the primary tumor and on the presence of metastases to the regional lymph nodes. In most cases the treatment still includes surgery in combination with radiotherapy, both of which must be coordinated. Complete treatment of the primary tumor and of the lymph node areas is of great importance even in non-advanced cases. Extensive resection of the tumor offers another mode of curative therapy, especially in combination with reconstructive surgery. Chemotherapy appears to be useful in this group of tumors, but only if aggressive cytoxic agents are given. However, it cannot replace the modalities of treatment mentioned above. Patients with speech and mastication disability after therapy usually need special care. Periodic controls are necessary for even longer than five years, to ensure detection of possible recurrences and second tumors.

Adult↗
PubMed1978

[The value of radiotherapy in the treatment of lip neoplasms].

About 80% of carcinomatous lesions of the lip are smaller than 2 cm in diameter, have little tendency to infiltrate, grow in the lower lip, are histologically well differentiated and do not have, or develop later, regional metastases. Of these carcinomas 95% are cured by the various methods of radiotherapy. The criteria for a more serious prognosis, such as expansive growth, deeper infiltration, location on the upper lip and/or the commissures, undifferentiated grading and regional lymphatic metastases, are found only in a minority of patients with carcinoma of the lip. However, even for tumors of the T3 category rates of cure of over 90% are reported, as confirmed by our own results with supervoltage irradiation with fast electrons of the betatron during the years 1961-1970. The techniques and indications of interstitial Curietherapy with iridium-192 wires are described. The treatment of primary lymphnode metastases, which should be confirmed histologically or cytologically before therapy, is described in detail. Neck dissection is superior to irradiation therapy. General elective neck dissection, as normally performed for carcinoma of the oral cavity, is not justified because of the low rate of metastases and the results of elective therapy. A case report demonstrates the poor prognosis in patients with regional fixed metastases.

Hair Removal↗
PubMed1978

[Computer-assisted estimation of the dose distribution in intracavitary radiation therapy (author's transl)].

A new version of a computer-assisted method for determination of the dose distribution in the pelvis of female patients treated with sealed radioactive radium or caesium sources is outlined. The position of the sources in a coordinate system centered on the symphysis is determined stereoradiographically. The dose values are calculated either for singular body points or for points situated on transversal, frontal and sagittal planes through the symphysis or for planes parallel to these. In consideration of the fact that for each patient the anatomical position of the calculation planes can be reproduced with sufficient precision, it is possible to cumulate on each plane the dose values obtained from treatment performed at different times. Experimental controls show good agreement between calculated and measured dose values. Some clinical examples of dose calculation for sagittal planes and of cumulated dose values for a frontal plane 7.4 cm underneath the symphysis are presented.

Cesium Radioisotopes↗
PubMed1978

[Lymph node metastases and ureteral obstructions as prognostic parameters for the percutaneous radiotherapy of the bladder carcinoma (author's transl)].

The results of a percutaneous radiotherapy of 136 patients with bladder carcinomas who were treated between 1966 and 1972 are presented in a retrospective study. Before the beginning of the treatment, the diagnosis of these patients had been verified by a lympho-cavo-urography. 21% of the patients had a pathological lymphogram and 40% a pathological urogram. The survival time of patients with normal and those with pathological lympho-cavo-urography showed a difference which was statistically significant (p less than 0.001). There was no patient with inhibited urinary defluxion and demonstrated lymph node metastases who lived longer than 21 months after the treatment. Exclusive percutaneous radiotherapy and primary total cystectomy cannot be considered as curative therapeutic methods. If metastases in the lymph nodes of the regio iliaca communis and paraaortal are demonstrated by lymphography, the prognosis is unfavourable and only palliative methods are justified.

Humans↗
PubMed1977

[Contribution of radiotherapy in the local-regional treatment of breast cancer].

The role of radiotherapy in the treatment of mammary carcinoma is reviewed. The indication for postoperative radiotherapy in cases of primary tumors T2 and T3, particularly in the presence of metastatic lymph nodes (N1), is still given. For stage 1 (T1/T2 N0), postoperative radiotherapy may be omitted or can be limited to the lymphatic area which has not been surgically explored. Pre-operative radiotherapy for the more advanced stage (T3/T4 and N2) has proven more effective than postoperative irradiation. Radiotherapy as an exclusive procedure in the sense of a curative, non-mutilating treatment for small breast cancers(T1/T2 NO) provides, if correctly administered, the same 5- and 10-year survival rate at surgical amputation. The arguments against the use of radiotherapy (lymphopenia, diminished immunological reactions, frequency of hematogenic metastases) are discussed.

Aged↗
PubMed1975

[Indications for radiotherapy in gastrointestinal tumors].

As a pre- or postoperative measure, radiotherapy can contribute to the treatment of many gastrointestinal malignancies. Postoperative radiotherapy is recommended in malignant lymphoma of the stomach and the intestine, as well as for invasive and totally resected carcinoma of the recto-sigmoid in order to prevent local recurrences. Preoperative radiotherapy can be attempted for carcinoma of the lower third of the esophagus and extended carcinoma of the stomach and the rectum, as long as no better therapeutic association is available. Finally, curative radiotherapy can be administered for squamous cell carcinoma of the esophagus and the anus, with a reasonable chance of success, to avoid subjecting the patient to major surgery.

Adenocarcinoma↗