Biomedical subjects

P Vine

Publications and source records attributed to P Vine.

6 recordsLinked to original sources

PubMed1997

Perceived burden among caregivers of adults with serious mental illness: comparison of black, Hispanic, and white families.

Differences in perceived burden were investigated among black, Hispanic, and white groups of caregivers of adults with serious mental illness. Controlling for sociodemographic characteristics and caregiving-related stressors, black caregivers tended to report less burden than whites, a result not explained by protective mechanisms (social support, religious involvement, illness attributions). No statistically significant differences were found in perceived burden between Hispanic and white caregivers.

Adaptation, Psychological↗

PubMed1991

Families as advocates for the mentally ill: a survey of characteristics and service needs.

A mail survey of family members of individuals with psychiatric disabilities assessed perceptions of service needs. Housing needs emerged as the primary concern of these family members. Policy implications regarding the family are considered in light of public responsibility for the care and support of those with psychiatric disabilities.

Community Mental Health Services↗

PubMed1991

Ninety nine and counting.

1992 is the centenary of school nursing. School nurses have a history to be proud of. Amy Hughes, the first school nurse, was one of a group of nurses who were instrumental in the founding of not only school and district nursing but the Society of Trained Masseuses as well.

History, 19th Century↗

PubMed1990

A case of Krabbe's leukodystrophy without globoid cells.

Krabbe's globoid cell leukodystrophy is a rare hereditary progressive neurological disease of infants, in which there is deficient activity of galactosylceramide beta-galactosidase. The pathological hallmark is the presence of multinucleated globoid cells in the white matter associated with severe myelin depletion and gliosis. We report a second case where galactosylceramide beta-galactosidase deficiency was proven but no globoid cells were found in the brain. Symptoms began within the first 10 months of life and a deficiency of galactosylceramide beta-galactosidase activity was demonstrated in peripheral blood leukocytes and skin fibroblasts. The child survived till 8 yrs 7 mths. The reason for the absence of globoid cells is not clear but may be related to different effects of the gene mutation on the four substrates or possibly the interaction of sphingolipid activator protein-2.

Brain↗

PubMed1986

Buccal morphine premedication. A double-blind comparison with intramuscular morphine.

Fifty patients were admitted to a double-blind, double-dummy study comparing buccal morphine 10 mg tablets and intramuscular morphine sulphate 13.5 mg as premedication. This investigation was performed on the basis of favourable results obtained in an earlier 25 patient pilot study designed to examine the efficacy, safety and patient acceptability of buccal morphine 10 mg tablets as pre-anaesthetic medication. Both studies and sets of results are presented and show that, whilst buccal morphine is a safe alternative means of delivering opioid premedication, which is acceptable to the majority of patients, an equivalent intramuscular morphine dose is nevertheless a more effective premedicant in terms of anxiolysis and wakefulness, as assessed by linear analogue scores. Pharmacokinetic considerations are advanced both to explain the differing clinical efficacies of the two means of morphine administration and to indicate that improved per- and immediate postoperative analgesia might be obtainable in patients premedicated with buccal morphine.

Administration, Oral↗

PubMed1976

The denervated cremaster muscle of the guinea-pig as a pharmacological preparation.

The pharmacological responses of both denervated and innervated cremaster muscle preparations from the guinea-pig have been investigated and compared. Acetylcholine (ACh) dose-response curves were obtained in both preparations. The affinity constants for (+)-tubocurarine and for atropine were calculated and indicated that the ACh receptors in both preparations were nicotinic. Histamine dose-response curves could be obtained only in the denervated preparation. The response was unaltered by metiamide, and the affinity constant for mepyramine fitted in with those previously obtained by others on ileum and trachea, indicating that the histamine receptors are H1 in type. Sustained contractions were obtained to adrenaline and noradrenaline but not isoprenaline, with the denervated preparations. Schultz-Dale responses were obtained with denervated muscle in sensitized guinea-pigs. This preparation did not respond to 5-hydroxytryptamine, bradykinin, or the slow-reacting substance of anaphylaxis.

Acetylcholine↗