[Computerized study of 20 years of thyroid cancer surgery].
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Biomedical subjects
Publications and source records attributed to P Vuillard.
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During surgery on the right thyroid lobe, 15 cases of non-recurrence of the inferior laryngeal nerve were observed, among which two types of equal frequency. Embryologic data explain why this abnormality is always associated with an abnormal origin of the right subclavian artery, directly from the aortic arch. The right subclavian artery generally passes behind the oesophagus in these cases. These 15 cases represent 0,79% of the 1889 cases studied during a short period (1971-1978).
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Clioquinol, or 5-chloro-7-iodo-8-hydroxyquinoline (Vioform), and the internal standard, 5,7-dichloro-8-hydroxyquinoline are extracted from biological material in the form of their tetrahexylammonium salts into dichloromethane, where, in the presence of a methylating agent, both clioquinol and the standard are spontaneously transformed into their O-methyl derivatives. These derivatives can be purified by base-specific extraction and subsequently determined by gas chromatography; concentrations down to 10 ng per sample may be assayed. The method is compared with a previously reported procedure based on the O-acetyl derivatives.
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