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Biomedical subjects

P W Bergreen

Publications and source records attributed to P W Bergreen.

9 recordsLinked to original sources
PubMed1978

Chemotherapy trial with comp-F regimen in advanced adenocarcinoma of prostate.

Multiple agent combination chemotherapy was used to treat 16 patients with Stage D adenocarcinoma of the prostate in relapse. Agents employed were cyclophosphamide (Cytoxan), methotrexate, 5-fluorouracil, vincristine, and prednisone. Results were encouraging. Six of 16 patients achieved an objective response (2 complete, 3 partial, 1 stabilization) for a 37.5 per cent response rate. Eleven of 16 patients achieved a subjective response for a 69% response rate. Soft tissue metastases may be more responsive than bony lesions. Employment of vincristine made no obvious difference in response rate in those patients in whom it was used. Toxicity was only moderate. Further studies are warranted.

Adenocarcinoma↗
PubMed1978

Construction of hemibladders and cutaneous vesicostomies for bilateral renal function studies. A new technique in Macaca arctoides.

A surgical technique for the construction of hemibladders and permanent cutaneous vesicostomies in Macaca arctoides is described. Serial studies of renal function were performed in sedated monkeys before and 1 or more months after division of the bladder. The results of the studies confirm our previous observation that renal function in monkeys is comparable to that in man and show that (i) the surgical procedure is successful in the majority of instances; (ii) simultaneous determinations of renal function of the right and left kidneys are comparable to function observed before dividing the bladder; and (iii) studies of function of the two kidneys may be repeated for 18 months or more and as often as three times a week. We conclude that the procedure provides an opportunity for prolonged observation of changes in renal function and morphology of a single experimentally manipulated kidney compared to (i) the normal function and morphology of the kidney before inducing disease and (ii) the function of a normal contralateral kidney.

Animals↗
PubMed1977

Therapeutic renal infarction.

Pre-nephrectomy therapeutic renal infarction by injecting gelfoam into the renal artery was done in 10 patients with hypernephroma. This technique facilitates nephrectomy and decreases blood loss. A post-infarction syndrome characterized by flank pain, fever and nausea occurred in most patients. In addition, a dialysis patient underwent bilateral renal infarction with improvement of blood pressure control. Distal embolization of gelfoam occurred in this patient, resulting in significant gangrene of 1 foot.

Adenocarcinoma↗
PubMed1977

Pulmonary dysfunction after lymphangiography.

Pulmonary function tests were done on 15 patients before and after bipedal lymphangiography. Lymphangiography was associated with an approximate 10 per cent reduction in lung volume. This phenomenon persisted for 48 to 72 hours. The probable mechanism for this reduction is closure of terminal airways or alveolar ducts or both and is reversible by beta-adrenergic drugs. The reduction does not correlate with the severity of pre-existing pulmonary disease. The degree of pulmonary impairment can be assessed roughly by measurement of the vital capacity. An operation can be performed safely 3 to 5 days after lymphangiography.

Aged↗
PubMed1976

Treatment of uncontrolled hypertension by therapeutic renal infarction.

Certain hemodialysis patients need to be made anephric, either surgically or physiologically. Bilateral renal infarction with shredded absorbable gelatin sponge (Gelfoam) was performed on a woman with malignant hypertension being maintained on chronic center dialysis who was too great a surgical risk for bilateral nephrectomy. Peripheral embolization complicated the procedure resulting in a forefoot amputation for dry gangrene two months later. Her postinfarction peripheral plasma renins remained elevated, and she remained hypertensive but was more easily managed with fewer drugs. This technique has been successfully used by others in 1 patient with chronic renal failure and heavy proteinuria and another with hypertension and a solitary kidney. If, as in our case, postinfarction plasma renins remain elevated and hypertension persists, bilateral nephrectomy could be performed at a later date or infarction could be repeated.

Adult↗