The efficacy of single doses (1.2 g) of soluble aspirin and aspirin tablets was determined in a randomised, placebo-controlled, double-blind, parallel study in 90 patients (45 females) with postoperative pain after removal of impacted lower third molars. Also investigated was the relationship between plasma aspirin esterase activity and overall pain scores after both aspirin preparations. Patients reported significantly less pain (p less than 0.001) after treatment with aspirin than after treatment with placebo. However, patients receiving soluble aspirin reported both an earlier onset and a longer duration of pain relief than those who received aspirin tablets. A significant correlation was observed between plasma aspirin esterase activity and overall pain scores after both soluble aspirin (r = 0.57, p less than 0.01) and aspirin tablets (r = 0.51, p less than 0.02). It is concluded that soluble aspirin is the preferred aspirin formulation for treating postoperative pain after third molar surgery and that plasma aspirin esterase activity is determinant of a patient's analgesic response to aspirin in postoperative dental pain.

Adolescent↗

PubMedDate not supplied

Measuring facial swelling using three-dimensional imaging.

Requirements exist clinically for quantitative analysis of facial swelling. A quick and non-invasive measurement of facial volume is desirable. The acquisition of three-dimensional images, corresponding to spatial models of patients' facial surfaces, has been facilitated using a Spatial Vision System (SVS) developed by Thorn EMI Central Research Laboratories (UK). The SVS acquires four video images (two step pairs) and constructs a three-dimensional surface representation using stereo matching of spatial features acquired using 'speckled' illumination. Pre- and post-operative binary volumetric images are then spatially aligned using surface matching algorithms. Accuracy of registration is optimized using Match Volume Excavation. Segmentation of post-operative swelling is achieved by volume differencing in combination with morphological erosion. Volumetric quantification is achieved using a method of three-dimensional region growing, giving the number of connected voxels in the image volume from a user selected seed point. Accuracy of image acquisition has ben quantified by imaging a range of hemispherical phantoms of known volumes. The mean error in repeated measurement of volume was found to be within 3.5%. The perception of temporal changes in facial swelling is highly subjective. Further work is being undertaken to develop and Enhanced Reality visualization tool in which graphical swelling annotations are combined with real-time patient images.

Computer Simulation↗

PubMedDate not supplied

Remotivation for return to community life.

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Motivation↗