After oral doses to dogs of 14C-tinidazole, a 5-nitroimidazolyl antiprotozoal compound, a major and previously unidentified radioactive metabolite was isolated from urine and shown by FAB mass spectrometry and n.m.r. spectroscopy to be ring-hydroxylated. The exact identity of this metabolite was established by X-ray diffraction analysis as ethyl 2-(5-hydroxy-2-methyl-4-nitro-1-imidazolyl)ethyl sulphone. The apparent migration of the nitro group from the 5 position in the parent drug to the 4 position in the metabolite is a novel metabolic route.

Animals↗

PubMed1979

The occurrence of proliferative kidney disease on a chalk stream.

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Animals↗

PubMed1975

Proliferating angioendotheliomatosis.

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Aged↗

PubMedDate not supplied

Enteric redmouth vaccines.

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Animals↗