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Biomedical subjects

P Ward-Booth

Publications and source records attributed to P Ward-Booth.

At least 19 recordsLinked to original sources

A radiographic analysis of computer prediction in conjunction with orthognathic surgery.

This retrospective study analysed the accuracy and reliability of predictions generated in patients treated with orthognathic surgery by comparing Quick Ceph Image software (Quick Ceph Image Pro version 3.0) predictions with post-surgical lateral cephalographs. Pre- and post-surgical lateral cephalographs of 28 adult patients (12 males and 16 females) were scanned into the computer and 28 landmarks were identified and digitized. Digitization error was assessed from repeated digitization. Fourteen measurements of the predicted and actual postsurgical hard tissue landmarks were compared using Student's t-test. Results showed a good correlation between repeated digitization for all measurements. Student's t-test indicated that 10 of the 14 measurements showed no statistically significant differences. Only the ANB (P=0.008), FMA (P=0.001), SN-Mxl (P=0.03) and Wit's (P=0.0001) showed statistically significant differences between the predicted and actual measurements. However only the Wit's showed clinical significant differences between the two measurements. Caution still must remain as the surgeon may not achieve his planned position in an individual patient. In some cultures there may also be medico-legal implications of these predictions.

Adolescent↗

[Initial experiences with digital 3-dimensional stereophotogrammetry imaging].

A digitised three-dimensional (3-D) image of the face has many valuable uses. These include accurate measurements of facial morphology, clinical documentation and objective analyses of surgical procedures. A new system presented here, based on stereophotogrammetric techniques, instantaneously captures digitised images using high-resolution cameras. It has an accuracy of more than 0.5 mm RMS and creates the 3-D image from approximately 20,000 points. The principles of the image capturing are demonstrated and the potential uses discussed. Surgical changes of the soft tissue in two patients following orthognathic surgery are also illustrated. This new capturing and measurement system provides a simple method of determining 3-D changes in soft tissue following surgery and is a useful tool for clinical purposes.

Adult↗

Technique for intraoral inverted 'L' osteotomy.

The technique of intraoral inverted 'L' osteotomy mandibular advancement is technically straightforward and has a low morbidity. It is indicated for mandibular advancement, particularly when the risk of inferior alveolar (dental) nerve damage is unacceptable.

Adolescent↗

A prospective study of trephined bone grafts of the tibial shaft and iliac crest.

Autogenous cancellous bone grafting is a common procedure in maxillofacial surgery. Open harvesting usually results in a long scar and considerable morbidity, but harvesting using a trephine can be done through a smaller scar with minimal morbidity. The commonly used anatomical areas for trephine harvesting are the iliac crest and the tibial shaft. A prospective study was carried out in 30 patients to compare the technique and the morbidity as perceived by patients using a visual analogue scale (VAS) and by an independent observer. The surgical anatomy and techniques are described. The results show no significant difference between the two groups, but the tibial trephine procedure is easier, quicker, and causes less blood loss. The total scores for pain and difficulty in walking were much less for tibial than that for the iliac grafts.

Adolescent↗

Multiple salivary mucoceles in a young boy.

A rare case of multiple mucoceles in a 4-year-old boy is reported. The patients presented with multiple sessile swellings on his lower lip, with no obvious local aetiology. The patient was otherwise well. The lesions were excised surgically and histopathological examination confirmed the lesions to be extravasation-type mucoceles. The article includes a brief review of mucoceles.

Child, Preschool↗

Evaluation of different doses of soluble ibuprofen and ibuprofen tablets in postoperative dental pain.

The object of the study was to assess the comparative efficacy of three single doses (200, 400, 600 mg) of soluble ibuprofen and ibuprofen tablets after third molar surgery in 148 patients and aged 18-40 years. Outcome was measured by overall assessment of pain (AUC360) assessed from serial visual analogue scales, the number of patients taking additional analgesic and by overall assessment of medication evaluated on a five-point categorical scale. Over the 6-hour investigation period all the ibuprofen treatments with the exception of ibuprofen tablets 200 mg resulted in significantly less pain (p < 0.05) than placebo treatment. A large number of patients required additional analgesia during the investigation period, but the time to taking it was significantly earlier in the placebo group. No significant dose response (p > 0.05) was observed for either ibuprofen preparations assessed by the outcome variable of overall pain experience (AUC360) or time to additional analgesia. There was no significant difference in pain scores or time to taking additional analgesics between the respective doses of soluble and tablet formulations of ibuprofen. Both soluble and tablet formulations of ibuprofen provide effective pain control in the early postoperative period after removal of impacted third molars. There is little analgesic advantage in increasing the dose to 600 mg and only minimal benefit from using a soluble formulation of the drug.

Adult↗

Advances in the diagnosis and treatment of oral cancer.

Cancer of the oral cavity is fortunately rare in the Western world. However, rates are rising and are comparatively high in lower socioeconomic groups and in many metropolitan areas. Whenever possible, cancer of the oral cavity should be distinguished from "head and neck" cancers, because "site" is so important in the behavior of the disease. This review discusses the advantages and disadvantages of various methods of diagnosis, therapy, reconstruction, social rehabilitation, and pain control of oral cancer and of head and neck cancer.

Female↗

The use of radionuclide bone scintigraphy to determine local spread of oral squamous cell carcinoma to mandible.

In oral squamous cell carcinoma, conservative resection of mandible is not recommended if there is tumour invasion. The use of bone scintigraphy to obtain a more accurate assessment of tumour spread has been evaluated in comparison with radiographs and histology in 11 patients. Tumour invasion of bone was shown on scans and radiographs, but periosteal reaction to tumour was detected by scintigraphy only. Thus both scintigraphy and radiography are recommended for preoperative assessment of bony margins for radical resection.

Adult↗

Oral carcinoma: evidence for viral oncogenesis.

Since early this century, when Rous (1911) first demonstrated the association of a tumour (chicken sarcoma) with a transmissible agent, evidence has accumulated on possible associations between viruses and various neoplasms. There is now conclusive evidence linking some RNA viruses (Temin, 1972) and DNA viruses (Rapp, 1973) with tumours in animals--including sub-human primates (Leading article, 1982). Indeed, a serious complication of hepatitis B infection in man is now recognised to be hepatocellular carcinoma. (Editorial, 1982). The evidence association other viruses with human neoplasms is not unequivocal but there are strong associations between, for example, herpesviruses and some human malignant neoplasms (Klein, 1972; Rapp, 1973; zur Hausen, 1975).

Animals↗

Detection of RNA complementary to herpes simplex virus in human oral squamous cell carcinoma.

Biopsy specimens from patients with oral squamous cell carcinoma were examined by in situ hybridisation for evidence of RNA complementary to herpes simplex virus (HSV) type 1, HSV type 2, and adenovirus type 2. RNA complementary to HSV was found in 66% of carcinomas and 33% of non-malignant lesions from other patients. In a further study with internally paired controls, RNA complementary to HSV was found in 53% of carcinoma biopsy specimens but in no biopsy specimens of normal oral mucosa from the same patients. RNA complementary to HSV was found in over 50% of oral squamous cell carcinomas.

Adenoviruses, Human↗