Biomedical subjects
P Wheatley
Publications and source records attributed to P Wheatley.
Military surgery in Rwanda.
BACKGROUND: In April of 1994, a vicious civil was erupted in Rwanda, with more than 500,000 people massacred by extremist militias. The second United Nations Assistance Mission in Rwanda (UNAMIR II) deployed in August 1994 to monitor the ceasefire, with an Australian Defence Force Contingent of Health Service Support consisting of staff for the UNAMIR Head-quarters, and the Australian Medical Support Force (AS MSF). METHODS: A retrospective audit was conducted of all operative surgery performed during the year-long deployment, in the AS MSF operating theatres. RESULTS: Twenty surgeons rotated through in 6-week intervals. A total of 750 operations were performed on 547 patients, of which 636 (84.8%) involved civilians. A total of 558 (74.4%) cases were the result of trauma both accidental (38.4%) and war related (36%). The mean age of patients was 21.7 years. The age distribution was skewed, with 289 (38.5%) cases being performed on children. General surgeons performed a wide range of surgery, covering the majority of surgical specialties. These included cardiothoracic, neurosurgical, vascular and paediatric cases. Orthopaedic surgeons dealt with amputations, debridements and skin grafting in addition to bony injuries and infections. Children formed a substantial number of those treated, and required surgery for war-related injuries significantly more often than adults. CONCLUSIONS: Surgeons involved in future peacekeeping missions should be aware of the broad variety of clinical problems encountered, and undertake refresher training in the sub-specialties. Children are at great risk of violence in war, and if a civilization can be judged by the protection it affords its helpless, the Rwandan genocide and ensuing civil war represents a horrific example of the opposite extreme.
HIV-1 seroprevalence in pregnant women testing positive on serologic screening for syphilis.
Epidemic increases in active syphilis have been reported in the geographic areas hit hard by acquired immunodeficiency syndrome. Although both epidemics have been associated with illicit substance abuse, the extent to which recent increases in syphilis are linked to the human immunodeficiency virus (HIV-1) epidemic is uncertain. In order to define the frequency of syphilis and HIV-1 coinfection in the pregnant patients seen at City Hospital Center at Elmhurst, we saved syphilis-positive serologic specimens from obstetrical patients for anonymous HIV-1 antibody testing. Of 120 women who tested positive for syphilis, 7/120 (5.8%) had antibodies to HIV-1; of the 44 women with VDRL titers greater than or equal to 1:16 (suggestive of a recent infection), 1/44 (2.3%) had antibodies to HIV-1.
Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and rats.
Lamotrigine (LTG), 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, is a structurally novel anticonvulsant. The anticonvulsant profile of LTG following oral administration in two standard anticonvulsant tests, the maximal electroshock (MES) test in mice and rats and the pentylenetetrazol (PTZ) infusion test in mice, was studied in comparison with the known anticonvulsant drugs phenytoin (PHT), phenobarbitone, diazepam, carbamazepine (CBZ), sodium valproate, ethosuximide (ETH), and troxidone (TROX). ED50 values for the abolition of hindlimb extension (HLE) in the MES test and PTZ infusion tests and doses increasing the latency of PTZ-evoked clonus were determined. The duration of action of LTG was examined in rats and mice in the MES test by determining ED50 values for the abolition of HLE at various drug intervals to shock administration. In the MES test, LTG was well absorbed in both species, with peak activity at 1 h and persistence at this level of potency for at least 8 h. Of the drugs examined, LTG was ranked the most potent and persistent in both species. LTG also abolished PTZ-evoked HLE, while ETH and TROX were inactive. Clonus latency was not increased by LTG, PHT, or CBZ, but was significantly increased (p less than 0.05) by the remaining anticonvulsants. Thus, LTG resembled PHT and CBZ in its ability to block HLE but not to increase PTZ-induced clonus latency. Acute behavioural studies in mice and rats have suggested a wide separation between anticonvulsant doses and those producing behavioural impairment. These results suggest that LTG may be of value in the treatment of generalised tonic-clonic and partial seizures.
Pupils with special needs: a Scottish perspective.
The distinction between ordinary and special schooling in Scotland was effectively erased by the Education (Scotland) Act of 1981. This Act recognizes that any pupil who requires extra support to succeed in a regular classroom is a child who has special education needs. Presently, all pupils who, for whatever reason, do not cope successfully at school are collectively referred to as children with learning difficulties. The term "learning difficulties" reflects a broader spectrum of problems than those characteristically found in the category of learning disabilities used in the United States. In cases of dyslexia, the term "specific learning difficulties" (a subgroup of learning difficulties) is also used. All special education provision in based on individual needs. A child's needs are interpreted in relation to a continuum of special education needs and in the context of his or her unique environment. For pupils with learning difficulties, the needs-assessment process is typically informal and rarely results in an official record of need being opened for them. A description of Grampian Region, one of the largest administrative units in northern Scotland, reveals how special educational practice is organized to respond to pupils with learning difficulties in the current educational climate.