Biomedical subjects

P Wolff

Publications and source records attributed to P Wolff.

10 recordsLinked to original sources

PubMed1992

A novel semi-automated paramagnetic microparticle based enzyme immunoassay for hepatitis C virus: its application to serologic testing.

A new rapid serologic enzyme immunoassay for antibodies to hepatitis C virus (HCV) is described. The assay combines synthetic peptide and recombinant antigens representing putative structural and non structural HCV gene products with paramagnetic microparticle assay (MP assay) technology. Assay readout is based upon an enzymatically generated fluorescent product which is quantified with a novel semi-automated washer/reader instrument system. Assay sensitivity and specificity was determined to be greater than the first generation HCV C-100 EIA using a non-A, non-B hepatitis disease panel, an HCV performance panel, an HCV seroconversion panel, dilutions of HCV reactive sera, and random volunteer blood donor specimens.

Evaluation Studies as Topic↗

PubMed1992

Evaluation of clinical nurse specialist practice.

Evaluation of the impact of clinical nurse specialist (CNS) practice in today's health care environment is currently one of the most important issues facing these advanced practitioners and nursing administrators. The unique contributions of CNS practice can be demonstrated through use of sophisticated evaluation methods. This paper begins with a discussion of types of evaluation (structure, process, and outcome) that have been utilized in the past and then describes the structure, developmental process, and function of an evaluation instrument recently implemented by a group of CNSs. The evaluation instrument is a step towards the ultimate goal of process-outcome evaluation, the most sophisticated method of evaluating the impact of the CNS. The benefits of utilization of this tool are presented from the perspective of CNSs and nurse administrators.

Employee Performance Appraisal↗

PubMed1991

Mental imagery and dyslexia: a deficit in processing multipart visual objects?

Dyslexic and normal control subjects memorized simple line patterns inside a grid and subsequently judged whether an "X" would have fallen on the pattern had it been present in an empty grid. The patterns were letters and novel shapes. The grids were presented to the left visual field, to the right visual field, or in central vision. Dyslexic subjects had difficulty generating images of multipart patterns, but this deficit was limited to letters. The findings suggest that dyslexics may have selective difficulty integrating visual information stored in long-term memory.

Adolescent↗

PubMed1991

Conversational skills of individuals with fragile-X syndrome: a comparison with autism and Down syndrome.

The conversational skills of 18 individuals with fragile-X syndrome (FXS) were compared with those of two other matched groups with autism and Down syndrome. The FXS group used more eliciting forms in conversation than those with Down syndrome, and also used partial self-repetition more often than the other two groups. The Down syndrome group had more speech dysfluencies than those with autism, but not more than those with FXS. The autistic group used more inappropriate phrases. Qualitative analysis of behavioral phenotype may reveal differences in communicative organization among subgroups whose retardation is based on different genotypes. In addition, analysis of verbal strategies during conversation suggests important differences between individuals with FXS and autism.

Adolescent↗

PubMed1979