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Biomedical subjects

P Worthington

Publications and source records attributed to P Worthington.

At least 19 recordsLinked to original sources
PubMed1992

Odontogenic myxoma: histochemical and ultrastructural study.

Three cases of odontogenic myxoma are presented, two of which were located in the mandible and one in the maxilla. All cases demonstrated similar morphology by light microscopy. Immunohistochemical studies demonstrated positive reaction with antibodies to vimentin and actin, and negative reaction to antibody to S-100 protein. A 127-day-old human tooth bud was used as a control. The ultrastructural features performed on Case 3, when combined with the immunohistochemical findings suggest that the cells comprising odontogenic myxoma are of myofibroblastic origin.

Actin Cytoskeleton↗
PubMed1990

Oral histoplasmosis as a presenting disease in acquired immunodeficiency syndrome.

A 43-year-old homosexual man visited his dentist with painful, nodular, ulcerated lesions on the soft palate, right buccal mucosa, and right posterior maxillary gingiva. Serologic studies for exposure to human immunodeficiency virus, performed before biopsy, were positive. Biopsy of the maxillary gingiva demonstrated sheets of histiocytes containing small intracellular yeasts, which on culture were identified as Histoplasma capsulatum. Bilateral leukoplakic lesions with some vertical furrowing involving the lateral borders of the tongue were also noted. Histologically, hyperkeratosis and fungal hyphae were identified. The patient was treated for histoplasmosis with amphotericin B, which resulted in significant improvement of the oral lesions. He was subsequently hospitalized for fatigue and dyspnea and was found to have Pneumocystis carinii pneumonia. Pulmonary status deteriorated within a 3-week period, and the patient died. Autopsy findings were negative for histoplasmosis but positive for necrotizing and cavitary P. carinii pneumonia, pulmonary and hepatic herpes simplex infections, and pulmonary and intestinal cytomegalovirus infection.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Psychological impact of osseointegrated dental implants.

This longitudinal study of 39 patients who underwent treatment involving osseointegrated implants examined problems in oral and psychosocial functioning, expectations and experiences of difficulties with surgery, satisfaction with surgery, body image, neuroticism, self-concept, and extroversion. Patients completed six questionnaires from before phase 1 surgery to the final recall appointment for the new prosthesis (12 to 18 months after phase 1 surgery). The most common problems reported before treatment were those associated with eating; esthetics was less of a concern. Significant improvements in all problem areas were observed immediately after phase 2 surgery. Expectations of surgery-related problems were generally consistent with experiences immediately after phase 1 surgery, but more negative than experiences following phase 2 surgery. Body image before treatment was most negative vis-à-vis teeth. Significant improvements were found not only regarding teeth, but also on facial, mouth, and even overall body image. Satisfaction scores were generally high, but showed continued improvements through the final assessment. The only group experiencing negative outcomes consisted of patients scoring high on neuroticism.

Adult↗
PubMed1989

Mandibulotomy: a surgical approach to oral and pharyngeal lesions.

The history of mandibulotomy is reviewed. The surgical steps involved and the variations of techniques are discussed. Two illustrative cases are reported and the clinical applications of the approach are discussed. It is concluded that mandibulotomy has a place in the management of malignancies as well as awkwardly situated benign lesions as well as malignancies.

Adult↗
PubMed1988

Current implant usage.

The types of dental implants in current use are described with comments on the various designs, the materials of which the implants are made, the patient situations for which they are used, and the age range of patients treated. The training background of the various clinicians involved is mentioned and comparisons are made between the United States, Japan and Central Europe. Predictions for the future use of implants are made and areas for future research are indicated, based upon deficiencies in our present knowledge.

Dental Implantation↗
PubMed1987

Monocortical miniplate osteosynthesis.

The theoretic basis of noncompression plating using miniplates and monocortical screws is explained. The technique is described and the range of clinical applications in maxillofacial trauma and elective maxillofacial osteotomies is indicated.

Biomechanical Phenomena↗
PubMed1985

Energy expenditure after spinal cord injury: an evaluation of stable rehabilitating patients.

Caloric requirements for spinal cord patients are not well understood. Energy expenditure was measured by indirect calorimetry and compared with predicted expenditure by manipulations of the Harris-Benedict (Long and Rutten), Quebbeman, and Spanier and Shizgal equations, using actual and ideal body weight: 45 measurements were made on 22 spinally injured patients, who were medically stable in their early rehabilitation phase of treatment, and included quadriplegics, paraplegics, and patients with Brown-Sequard syndrome. Other nutritional parameters were also followed. Equations based on normal patients consistently overestimated energy requirements of spinally injured patients. From the time of injury, spinally injured patients appear to have a reduction in their energy needs proportional to the amount of muscle which has been denervated. This decrease in caloric requirements continues throughout the rehabilitation and plateau phases. We have demonstrated that stable, rehabilitating spinally injured patients require 23.4 kcal/kg/day. As a group, quadriplegics required 22.7 kcal/kg/day, and paraplegics 27.9 kcal/kg/day. This represents only 45 to 90% of the recommended calories for maintenance as calculated by any of these recognized formulae, based on normal heights, weights, age, and sex, when using either current weight or ideal body weight. Spinally injured patients as a group are subjected to fluctuations in weight during treatment. Our own patients tended to become obese approximately 12 months after spinal cord injury on uncontrolled diets. All patients underwent an initial weight loss which was greater in the quadriplegics as a group, compared with paraplegics. On uncontrolled diets, our patients gained an average of 1.7 kg/wk and this was also greater in the quadriplegic group.

Adolescent↗
PubMed1977

Pleomorphic adenoma of the nasal septum.

A brief review of the world literature on pleomorphic adenoma of the nasal septum is presented. One further case is reported, treated by surgical excision via lateral rhinotomy. Alternative surgical approaches are considered.

Adenoma, Pleomorphic↗
PubMed1977

The benign lymphoepithelial lesion of the salivary glands. A case report.

The literature on the so-called benign lymphoepithelial lesion of the salivary glands is reviewed. A case is reported demonstrating progression to malignant lymphoma (lympho-sarcoma) over two years. Other examples of autoimmune disorders developing malignant lymphoma are recalled.

Carcinoma, Squamous Cell↗