Biomedical subjects

P Yargicoglu

Publications and source records attributed to P Yargicoglu.

8 recordsLinked to original sources

PubMed2000

Effect of sulfur dioxide inhalation on erythrocyte antioxidant status and lipid peroxidation in experimental diabetes.

The effect of sulfur dioxide (SO(2) ) on red cell antioxidant status and lipid peroxidation was examined in this research. Forty healthy male albino rats, aged three months, were divided into four equal groups: Control (C), SO(2) +C (CSO(2) ), diabetic (D) and SO(2) +D (DSO(2) ). Experimental diabetes mellitus was induced by i.v injection of alloxan with a dose of 50 mg/kg body weight. Ten ppm SO(2) was administered to the animals of SO(2) exposed groups in an exposure chamber for one hr/day x 7 days/wk x 6wks while other groups were exposed to filtered air in the same condition. SO(2) exposure, while markedly decreasing Cu, Zn-Superoxide dismutase (Cu, Zn-SOD) activity, significantly increased glutathione peroxidase (GSH-Px), catalase (CAT), glutathione (GSH) and glutathione-s-transferase (GST) activities and TBARS values in CSO(2) and DSO(2) groups compared with their respective control groups. From these results, it could be concluded that adaptative changes occurred in antioxidant systems that may counteract the free radical effect of SO(2) in the experimental groups.

Alloxan↗

PubMed1998

The effects of cadmium and experimental diabetes on VEP spectral data and lipid peroxidation.

Fifty-two healthy swiss male albino rats, aged three months were used in this study. They were divided into four groups: Control (C), diabetic (D), Cadmium (Cd) and diabetic + Cadmium (D + Cd) groups. Diabetic condition was induced in D and D + Cd groups by administration of alloxane (5 mg/100 g). After this treatment, Cd and D + Cd groups were injected with CdCl2 i.p. (2 mg/kg/week). At the end of the two months of experimental period, flash visual evoked potentials (FVEPs) of four groups were recorded and amplitude spectral analysis was computed by transient response-frequency characteristics (TRFC) method. Significant amplitude decrement was found in 2-4 Hz frequency band of D + Cd group in comparison with C group. On the other hand, our data showed that Cd treatment and diabetic condition caused a significant increase of lipid peroxidation in kidney, brain, retina and lens.

Analysis of Variance↗

PubMed1996

Cadmium induced alterations in somatosensory evoked potentials.

Pregnant Swiss albino rats were divided into three groups: control (C), cadmium (Cd) and non-cadmium (NCd) groups. Control animals received tap water; the Cd rats received Cd as CdCl2 in their drinking water during the experimental period, while the NCd group was given Cd during pregnancy, and given tap water after birth. Twenty-two days after birth, 15 rats (for each group) were taken from their mothers and continued to be treated with Cd (Cd group) or tap water (C and NCd groups) for an additional 38 days. After the treatment period, somatosensory evoked potentials (SEPs) of the three groups were recorded from central (Cz) referenced to frontal (Fz) following left posterior tibial nerve (PTN) stimulation. Amplitude spectra of SEPs were computed by fast Fourier transform (FFT) algorithm. There was a significant amplitude decrease in 1-3.5 Hz in the NCd group and 1-3.5 and 14-20 Hz frequency bands of the Cd group compared with the control group.

Analysis of Variance↗

PubMed1996

Effect of chronic cadmium exposure on VEP and EEG spectral components.

Pregnant swiss albino rats were divided to three groups as control (C), cadmium (Cd) and non-cadmium (NCd) groups. Control animals were received tap water while the rats of Cd group were received Cd as CdC12 in their drinking water during the experimental period. On the other hand, the NCd group was given Cd during pregnancy, but given tap water after birth. Twenty-two days after birth, fourteen rats (for each group) were taken from their mothers and continued to be treated with Cd (Cd group) or tap water (C and NCd groups) for an additional 38 days. After the experimental period, flash VEPs and EEGs of three groups were recorded and amplitude spectral analysis was computed by Transient Response-Frequency characteristics (TRFC) method. The mean amplitude (dB) of 1-3.5 and 14-20 Hz frequency bands for right response whereas 1-3.5, 4-7, 8-13 and 14-20 Hz frequency bands for left response of VEPs were decreased in Cd group compared with control group. On the other hand, significant differences were observed between Cd and control groups in all the frequency bands of EEGs except 6-8 Hz.

Administration, Oral↗

PubMed1995

ERP spectral analysis of cholesterol rich patients.

Visual event-related potentials (ERPs) were studied in twenty hypercholesterolemic (HC) patients and twenty age-matched healthy controls. ERPs were recorded in two different experimental conditions that the target stimulus (red light) was counted (Test 1) or uncounted (Test 2). Amplitude spectra of ERPs were computed by transient response-frequency characteristics (TRFC) method. Their maxima were found to occupy the frequency bands of 1-2, 3-4, 5-7, 8-12, 13-20, 20.5-32 Hz. The amplitude mean (decibel) of 1-2 and 3-4 frequency bands were decreased in Test 2 compared to Test 1 in the control group, but no significant amplitude differences were found between Test 1 and Test 2 in the HC group.

Adult↗

PubMed1995

Event-related potentials in hypertriglyceridemia.

Event-related potentials (ERPs) of twenty-three hypertriglyceridemic (HTG) patients and twenty-three age-matched healthy controls were recorded in two different experimental conditions that the target stimulus was counted (Test 1) or uncounted (Test 2). Latencies of each wave were inside normal limits in all patients. No differences were found in the P3b amplitudes of Test 1 case among HTG and control subjects. Amplitude spectra of ERPs were computed by transient response-frequency characteristics (TRFC) method. Their maxima were found to occupy the frequency bands of 1-2, 3-4, 5-7, 8-12, 13-20, 20.5-32 Hz. When comparing Test 1 with Test 2, significant amplitude differences were found in 1-2 and 3-4 frequency bands of controls and 1-2 and 13-20 frequency bands of patient group.

Adult↗

PubMed1995

The effect of aging on spectral parameters of event-related potentials.

Forty-two healthy subjects ranging in age from 20 to 73 were divided into three groups according to age; a young group (20-33 years), a middle-aged group (34-49 years) and older group (50-73 years). Event-related potentials (ERPs) of three groups were recorded in two different experimental conditions that the infrequent stimulus was counted (Test 1) or uncounted (Test 2). ERPs were elicited using infrequent and frequent stimuli as red and green lights respectively. Spectral analysis of ERPs showed that decibel (dB) values of 1-2 and 3-4 Hz in young and middle-aged groups while dB value of 1-2 Hz in older group were significantly decreased in Test 2 compared with Test 1. When the number of subjects displaying amplitude maximum in each frequency band was considered, significant differences were found in 1-2 and 5-7 Hz frequency bands of young and middle-aged groups, but no significant differences were found for older group.

Adult↗

PubMed1993

Spectral analysis of event related potentials.

Event-related brain potentials (ERPs) of twenty normal subjects with no sign of neurologic diseases were measured by applying nontarget and target stimuli as green and red lights respectively. ERPs were recorded in two experimental conditions that the target stimulus was counted (Test 1) or uncounted (Test 2). The spectral analysis of ERPs recorded for Test 1 and Test 2 were computed by using the Transient Responses Frequency Characteristics (TRFC) method. Amplitude maxima were observed in the frequency bands as indicated: 1-2, 3-4, 5-6, 7-8, 8-12, 13-20, 20.5-36, 36 Hz and higher. When we compared Test 2 with the results of Test 1, we observed a significant decrease in the amplitude mean (decibel) of 1-2 Hz frequency band (p < .05). Repeated measures ANOVAs also showed that dB values of 1-2 Hz between counted and uncounted stimuli were significantly different (p < .04). When the number of subjects displaying amplitude maximum in each frequency band was considered, we have found important differences in 1-2, 3-4 Hz and 5-6 Hz bands.

Adult↗