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Biomedical subjects

P Zanen

Publications and source records attributed to P Zanen.

4 recordsLinked to original sources
PubMed1991

The effect of inhalation flow on the performance of a dry powder inhalation system.

Dry powder inhalation systems are composed of a small amount of active ingredients and a larger amount of filler. The drug particles are believed to be bound by the filler crystals. The complexes are too large to be inhaled and need to be separated before they enter the lungs. This is done by the air patients inhale through the inhaler. Asthmatics can show low inhalation flows and the performance of a dry powder inhaler at low flows was investigated. It was shown, that small particles (less than 5 microns) separate swiftly at low flows and larger particles (greater than 5 microns) will need higher flows. The conclusion is that dry powder inhalation preparation do not show a simple separation pattern.

Administration, Inhalation↗
PubMed1988

Bronchospasmolytic effects of salbutamol as powder inhalation in patients with reversible bronchial obstruction.

In a double-blind double-dummy crossover study, the effects of salbutamol dry powder inhaled from Salbutamol cyclocaps Pharbita 0.4 mg with the Pharbita inhaler and from a reference product were compared. On the first trial day, a single dose of one of the two preparations was administered, and 2 days later a single dose of the another preparation was administered, in random order. The effects on lung function (FEV1) were monitored from 15 to 360 min after administration. For both products the increase in FEV1 with reference to baseline values was statistically highly significant. There was no significant difference between the products.

Adult↗