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P Zech

Publications and source records attributed to P Zech.

187 records · Page 11Linked to original sources
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[Renal insufficiency in arterial hypertension in black Africa].

OBJECTIVES: The increased risk of renal disease due to high blood pressure observed in Black Americans would suggest ethnic factors are involved. We examined the clinical features of renal disease in patients hospitalized in Ouagadougou, Burkina Faso for high blood pressure to determine the risk factors in this black population. METHODS: From November 1988 to October 1990, 317 patients (mean age 49 +/- 14 years, 62.5% males) under treatment for high blood pressure or with a diastolic pressure > 90 mmHg without antihypertensive therapy were examined at their initial hospitalization. The patients were divided into socio-economic groups according to their professional occupation and level of education. Criteria of renal disease, including raised serum creatinine, proteinuria and blood urea nitrogen, together with factors related to hypertension, including obesity, diabetes mellitus, hypertensive retinopathy, heart failure, coronary artery disease, cerebral vascular events and hypertensive encephalopathy were analyzed. RESULTS: Severe hypertension, diastolic pressure > 130 mm Hg was observed in 43% of the patients. There was a significant inverse correlation between age and diastolic pressure (r = 0.23, p < 0.0001). Response to initial anti-hypertensive treatment was good in 88% and proportional to severity. Hospital mortality was 18.6% (59 patients) including 39 cases during the first two days. Mortality was not correlated with blood pressure, age, sex or socio-economic conditions. Renal disease was observed in 121 patients and chronic renal failure in 117 (44%). Effect of hypertension on at least one target organ was observed in 73.2% of the patients and on at least three target organs in 38.2%. Subjects with renal disease were younger (p < 0.02) and responded less well to treatment than those without renal disease. CONCLUSIONS: These clinical observations confirm the high prevalence of renal failure and the gravity of high blood pressure in Black Africans. In Burkina Faso, hospitalization for high blood pressure often leads to the discovery of terminal renal failure.

Adolescent↗
PubMedDate not supplied

[Epidemiology of severe chronic renal insufficiency in Burkina Faso].

We identified 174 cases of chronic severe renal failure (blood creatinine > 650 mumol/l) and/or blood urea > 35 mmol/l) in a retrospective study of patients admitted to hospital between January 1989 and June 1996. Of these patients, 110 were men and 64 were women. The mean age was 36 +/- 15 years. Fifty three patients had a history of hypertension before admission, 3 patients had diabetes and 3 had gout. The most frequent clinical signs were dyspnea (55.2% of all patients), fatigue (78.2%), vomiting (63.2%) and edema (66.1%). The prevalence of hypertension was 64.9%. Glomerulonephritis was found in 42.5% of patients, chronic interstitial nephritis in 16.1%, polycystic kidney disease in 2 cases, congenital renal hypoplasia in 4 cases and unclassified kidney disease in 14.4% of cases. End-stage renal failure was complicated by heart failure in 40.2% of patients, pericarditis in 31.6%, hemorrhage of the gastrointestinal tract in 15% and infections in 22.4%. 47.7% of the patients died following admission.

Adolescent↗