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Biomedical subjects

P Zemek

Publications and source records attributed to P Zemek.

At least 19 recordsLinked to original sources
PubMed1987

Sexual aggressivity and androgens.

Male sex hormones are ascribed a great importance in the literature from the point of view of sexual activity and aggressive behaviour. Two cases of sexually motivated murder are described, committed by delinquents with low levels of testosterone in plasma: one a patient with Klinefelter's syndrome; the other a man after castration. Even a decreased level of androgens, either primary or secondary, is not an absolute prevention of sexually aggressive behaviour.

Adult↗
PubMed1978

HLA antigens as possible markers of heterogeneity in schizophrenia.

The distribution of HLA-A-, B- -and -C-locus antigens was tested in 200 male patients with final diagnosis of schizophrenia. A significant increase of HLA-A28 and HLA-Cw4 antigens and haplotype A10--B18 was found. Indications were obtained for the increase of HLA-A1 in hebephrenic patients. It was presumed that the increase of CW4 represents the common denominator of the diverse findings on paranoid schizophrenia. The increase of CW4 indicates that the paranoid schizophrenia disease susceptibility locus is either the C locus itself or another closely linked locus (or loci). This would stress the importance of the HLA 'central' regions for HLA and disease associations. A hypothesis is presented which points to the possibility that HLA antigens could be genetic markers of three ethiopathogenetic subgroups of schizophrenia. The possible tests of this hypothesis are also suggested.

Adult↗
PubMed1977

HLA--Cw4 in paranoid schizophrenia.

On a group of 40 paranoid schizophrenic patients HLA serotypes for HLA--A, B, C antigens a significant increase of Cw4 was observed. It is argued that this finding represents the common denominator for previous data reporting increased A9 and A28 antigen in SCH because these antigens are frequently present on haplotypes bearing Cw4. The possible role of the HLA "central" parts, i.e. the chromosomal segment between HLA--A and HLA--B locus in the pathogenesis of schizophrenia was stressed.

HLA Antigens↗
PubMed1977

[Analysis of characteristics of the course and genealogic findings in patients with manic-depressive psychosis having a favorable outcome with lithium treatment].

With the aid of questionnaires it was established that among the patients who had begun long-term treatment with lithium since 1974, 85% of them continued to be treated prophylactically for at least 2 years. Favourable results in such treatment were considered to be in 91% of the cases. Some of the patients at the same time continued to take antidepressive and ataractic drugs. A study of the morbidity risk for relatives of the first degree of kinship in the group of patients treated only with lithium and in the group of patients receiving combined treatment did not demonstrate significant differences.

Adult↗