Biomedical subjects

P Zitoun

Publications and source records attributed to P Zitoun.

5 recordsLinked to original sources

PubMed1993

Effects of the cold pressor test on short-term fluctuations of finger arterial blood pressure and heart rate in normal subjects.

The effect of the cold pressor test on autonomic cardiovascular control was studied non-invasively by means of spectrum analysis of periodic heart rate and blood pressure fluctuations in ten normal subjects. Fast Fourier Transform algorithm based on a 256-point time series (sampling rate 2 Hz, i.e. 2-min and 8-s) was used to estimate the amplitude spectra of heart rate and blood pressure rhythmicity at the low frequency (70-140 mHz) and respiration related frequency (230-270 mHz) band. Respiration rate was controlled at 250 mHz. Auto- and cross-spectral techniques were used to determine the complex relationship between systolic blood pressure and heart rate fluctuations in the frequency domain. The spectral pattern of systolic and diastolic blood pressure showed a marked increment of the absolute and relative (100 multiplied with absolute value/total area under the curve of the amplitude spectrum from 15-500 mHz) low frequency component: control vs. cold pressor test--systolic blood pressure--absolute values (in [mmHg/Hz1/2]): 634.4 +/- 48.9 vs. 827.4 +/- 69.9*; relative values (in [%]): 26 +/- 2 vs. 32 +/- 2*; diastolic blood pressure--absolute values: 433.2 +/- 42.3 vs. 537.2 +/- 45.8*; relative values: 35 +/- 3 vs. 40 +/- 2*, (average +/- SEM, *P < 0.05). The cold pressor test induced no change in average heart rate; the absolute low frequency component in heart rate spectra increased clearly during the test: low frequency component (in [bpm/Hz1/2]): 586.9 +/- 89.9 vs. 712.0 +/- 91.4*, while the relative low frequency component did not change: 29 +/- 3 vs. 30 +/- 3.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1990

Spectral analysis of blood pressure and heart rate in conscious rats: effects of autonomic blockers.

We investigated the fluctuations which underly the spontaneous variability of blood pressure and heart rate in conscious rats. Intrafemoral blood pressure was computed to generate evenly spaced signals (systolic, diastolic, mean blood pressure, heart rate) at 200 ms intervals. This equidistant sampling allowed a direct spectral analysis using a Fast Fourier Transform algorithm. Systolic blood pressure and heart rate exhibited low-frequency oscillations (Mayer waves, 20-605 mHz) and a high- frequency oscillation related to respiration (1855 mHz). The respiratory fluctuations in heart rate were almost abolished by vagal blockade (atropine). Heart rate fluctuations in the low-frequency regime were diminished by vagal blockade or cardiac sympathetic blockade (atenolol). The respiratory frequency fluctuations in systolic blood pressure were markedly increased by alpha-sympathetic blockade (prazosin). In contrast, the low-frequency oscillations in systolic blood pressure were reduced by alpha-sympathetic blockade. These data indicate that in conscious rats: (1) the heart rate oscillation with respiration is vagally mediated; (2) the heart rate fluctuation in the low-frequency range is jointly mediated by beta-sympathetic and parasympathetic activities; (3) the respiratory oscillation in systolic blood pressure depends on fluctuations in cardiac output and is normally counteracted by the sympathetic tone; (4) the low-frequency oscillations in systolic blood pressure reflect the sympathetic activity to the resistance vessels.

Animals↗

PubMed1990

[Nervous mechanisms of spontaneous oscillations of systolic blood pressure and heart rate].

The phenomenon of rhythmic fluctuations in cardiovascular variables such as heart rate (HR) or arterial blood pressure (BP) has attracted the attention of workers in both pure and applied research. In recent years, the possibility of quantifying these oscillations by using power spectral analysis has aroused a growing interest. We investigated the fluctuations which underly the spontaneous variability of BP and HR in conscious rats. Intrafemoral pulsatile BP was computed to generate evenly spaced signals (systolic, diastolic, mean BP, HR) at 200 ms intervals. This equidistant sampling allowed a direct spectral analysis using a Fast Fourier Transform algorithm. Systolic Blood Pressure (SBP) and HR exhibited low frequency oscillations (Mayer waves, 20-605 mHz) and a high frequency oscillation related to respiration (1,855 mHz). The respiratory fluctuations in HR were almost abolished by vagal blockade (atropine). HR fluctuations in the low frequency regime were diminished by vagal blockade or cardiac sympathetic blockade (atenolol). The respiratory frequency fluctuations in SBP were markedly increased by alpha sympathetic blockade (prazosin). On the contrary the low frequency oscillations in SBP were reduced by alpha sympathetic blockade. These data indicate that in conscious rats: 1) the HR oscillation with respiration is vagally mediated, 2) the HR fluctuation in the low frequency regime is jointly mediated by beta sympathetic and parasympathetic activities, 3) the respiratory oscillation in SBP depends on fluctuations in cardiac output and is normally counteracted by the sympathetic tone, 4) the low frequency oscillations in SBP reflect the sympathetic activity to the resistance vessels.

Animals↗

PubMed1989

[Spectrum analysis of blood pressure and cardiac rate in the conscious rat].

Intrafemoral pulsatile blood pressure of conscious rats was computed to generate evenly spaced signals (systolic, diastolic, mean blood pressure, heart rate) at 200 ms intervals. This equidistant sampling allowed a direct spectral analysis using a Fast Fourier Transform algorithm. Systolic blood pressure and heart rate exhibited low frequency oscillations (Mayer waves, 20-605 mHz) and a high frequency peak related to respiration (1,765 mHz). The diastolic blood pressure and the mean blood pressure only exhibited low frequency oscillations. This procedure could be useful to analyze the various components of blood pressure variability.

Analysis of Variance↗

PubMed1985

Data acquisition and analysis of hemodynamic signals using a standard microcomputer.

Hemodynamic drug-effect studies require repetitive measurements and time-consuming calculations, particularly for the indices of left ventricular (LV) contractility and relaxation. To save time, we have created a system of acquisition, calculation, storage, and report of hemodynamic data processing E.K.G, peripheral arterial pressure, and LV pressure signals using a standard microcomputer (Apple II+) and simple accessory devices. The master program is written in BASIC Applesoft, with Mem/Dos as the disk operating system. A suite of utility routines, written in machine language, are used to program the A/D converter and to perform the vectorial calculations on the data. The software, written to process single-dose drug-effect studies, performs 1) data acquisition and storage as vectorial arrays accessible using BASIC, 2) monitor display, 3) calculations of the peripheral pressure and of the LV contractility and relaxation indices, 4) storage of the calculated indices, and 5) print-out of a report (curves and tables) at the end of each experiment and cumulated results of all the animals included in a protocol. The drawback of such a low-cost system is essentially the lack of available memory and the relatively slow speed of the microprocessor, which hinders simultaneous processing of indices needing nonlinear curve fitting and adequate print-out of protocols that are not single dose.

Animals↗