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P-J Pisella

Publications and source records attributed to P-J Pisella.

9 recordsLinked to original sources
PubMed2006

[In vivo assessment of corneal epithelial toxicity of timolol with benzalkonium chloride using very-high-frequency ultrasound imaging].

PURPOSE: To assess in vivo the corneal epithelial damage caused by a topical toxic medication using a 60-MHz ultrasound device. MATERIAL: and methods: A solution of timolol with 0.01% benzalkonium chloride (BAC) was applied twice a day in the test eyes of ten rabbits, and a BAC-free solution of timolol in the control eyes, for 56 days. We used a 60-MHz ultrasound device to evaluate the epithelial damage in BAC-exposed eyes, compared to control eyes. The clinical and ultrasound examinations were performed every week, and the histological analysis at the end of the experiment. RESULTS: The clinical findings were conjunctival redness, corneal staining and instability of the tear film. In vivo VHF ultrasound revealed a thinning of the epithelium of test eyes (from 40.9+/-1,6 microm at D0 to 31.8+/-3.4 microm at D56; p=0.0006 for D0 vs D56), while the epithelium of control eyes remained unchanged. Ultrasound epithelial thickness was correlated with corneal staining (at D34 and D56; p=0.0025 and 0.0377, respectively) and histological epithelial pachymetry (p=0.0176 for control and 0.0505 for tested epithelium). Moreover, we report qualitative VHF ultrasound imaging of early epithelial damage. CONCLUSION: This new device could be very useful in ocular toxicity evaluation as a reproducible and reliable tool for multicentric clinical research.

Animals↗
PubMed2006

[Quality of vision after cataract surgery in patients with prolate aspherical lens].

PURPOSE: To assess the quality of vision in pseudophakic patients with a prolate aspherical intraocular lens (IOL) compared to patients with a spherical IOL. PATIENTS AND METHODS: Twenty patients undergoing cataract surgery were divided into two groups according to the type of IOL: ten prolate aspherical IOLs (TECNIS Z9000, AMO, USA) and ten spherical IOLs (911 CeeOn Edge, AMO, USA). The integrity of ocular functions was assessed with clinical examination and multifocal electroretinogram. Contrast sensitivities were tested preoperatively in photopic, mesopic, and glared conditions. Postoperative examinations included refractive evaluation before and after mydriasis, pupil diameter, contrast sensitivities, and wavefront aberration analysis. RESULTS: Postoperative best-corrected visual acuity was 0.95 +/- 0.13 for the TECNIS group vs 0.98 +/- 0.11 for the 911 group (p=0.32). Refractive evaluation revealed mydriasis myopic shift in patients with the 911 IOL (- 0.10+/-0.30 D for the TECNIS group vs - 0.68+/-0.21 D for the 911 group, p=0.002). Mesopic contrast sensitivity was improved in the TECNIS group regarding medium and high spatial frequencies (p=0.003 and p=0.002, respectively), whereas photopic and glared contrast sensitivities were equal in both groups. RMS for high-order aberrations was 0.36 +/- 0.07 microm in the TECNIS group vs 0.33 +/- 0.19 microm in the 911 group (p=0.21), and spherical aberration was lower in patients with TECNIS IOL (Z40=0.03+/-0.06 microm vs 0.20+/-0.14 microm, for the TECNIS group and the 911 group, respectively, p=0.029). CONCLUSION: Combining contrast sensitivities and wavefront aberration analysis provided an objective assessment of the quality of vision in pseudophakic patients. Using prolate aspherical IOL could reduce spherical aberration and improve visual acuity, especially in mesopic conditions.

Aged↗
PubMed2006

[Intraocular foreign bodies: a descriptive and prognostic study of 52 cases].

BACKGROUND: The aim of this study was to determine prognostic factors as well as anatomical and functional outcomes in patients undergoing surgical removal of an intraocular foreign body, according to the ocular findings at presentation and surgical management. MATERIALS AND METHODS: Retrospective (1993-2003) clinical study of 52 consecutive patients, with univariate analysis adjusting for the initial and final clinical examinations, for the surgical strategy and complications. RESULTS: Final best corrected visual acuity of 5/10 or more was obtained in 35 patients (67%) and of 1/10 or more in 44 patients (85%). The prognostic factors of a final visual acuity less than 5/10 identified were an initial visual acuity less than 5/10 (p<0.001), age over 40 years (p=0.015), a foreign body larger than 3 mm (p=0.0015), and multiple surgeries (p=0.015). CONCLUSION: Thanks to recent surgical progress, final visual outcomes were excellent in 67% of patients. The initial visual acuity, age, the length of the foreign, and the number of surgical interventions were significant predictor factors. However, the anatomical and functional prognosis of intraocular foreign bodies remains difficult to establish at the initial clinical examination.

Adolescent↗
PubMed2005

[Repair of exposed hydroxyapatite implants using temporalis fascia: four case reports].

Using hydroxyapatite porous implants improves the functional and cosmetic results for patients after evisceration. However, exposure is still the most frequent complication and requires various surgical treatments. We present four patients who had an autologous temporalis fascia graft for an exposed hydroxyapatite implant 6 months to 5 years after the first evisceration. Mean follow-up was 17 months. We describe our surgical procedure and its results, and we discuss its advantages and its place in the management of exposed porous implants.

Aged↗
PubMed2004

[Current treatments of xerophthalmia in Sjögren's syndrome].

PURPOSE: To describe the large variety of treatments currently used in Sjögren's syndrome for one of its major manifestations, keratoconjunctivitis sicca or xerophthalmia. CURRENT KNOWLEDGE AND KEY POINTS: Sjögren's syndrome causes a diffuse immunoinflammatory disturbance of main lacrimal glands and the whole ocular surface. Dry eye syndrome is responsible for chronic and deep impairment of quality of life. Many different tear substitutes have been widely developed that are poorly efficient for relieving patients from their complaints. Tear substitutes of various viscosity from standard artificial tears to synthetic gels may be used. Hyaluronic acid is currently the most promising tear substitute, but all eye drops and gels are only efficient in mild to moderate dry eyes and keratoconjunctivitis sicca mostly resists to lubricants. Moreover, the latter may increase patients' complaints when they are associated to preservatives, antiseptic drugs that have widely demonstrated their toxic or irritating potential. Preservatives are, therefore, to be avoided whenever possible in keratoconjunctivitis sicca, by using monodose disposable packaging or specific bottle filtering or eliminating the preservative. Stimulation of lacrimal and salivary secretions with systemic pilocarpine, or obturation of lacrimal puncta in order to limit the drainage of tears in lachrymal ducts may be useful in most severe forms of Sjögren's syndrome. However, the development of topical cyclosporine and other immunomodulating agents is the most relevant progress in the treatment of keratoconjunctivitis sicca in Sjögren's syndrome. PERSPECTIVES: The future for treating Sjögren's syndrome is most likely to pass through the use of new drugs capable of treating the disease or at least its mechanisms, and not only to try to relieve symptoms with poorly efficient tear substitutes.

Administration, Topical↗
PubMed2004

[Post operative Enterococcus faecalis endophthalmitis: three case report].

We report three cases of endophthalmitis following cataract extraction. Enterococcus faecalis was the causative organism in all of them. Initial visual acuity was only light perception in all cases, final visual acuity was negative light perception in two cases, and light perception in one case. After initial improvement, inflammation was exacerbated in one patient and evisceration realized. The capsular bag was examined using scanning electron microscopy and it was shown that enterococci were adherent to the capsular bag, four months after the onset of the infection. Enterococcus faecalis can be the causative agent both of an acute and a chronic form of post operative endophthalmitis. Experimental studies on rabbit eyes could explain the poor prognosis of these endophtalmitis and focused on bacterial toxins. The contamination appears to be post operative, because Enterococcus faecalis is not a commensal agent of the conjunctiva. So we have to inform our patients about some hygienic habits, to prevent from this devastating complication of cataract surgery.

Aged↗
PubMed2004

[Treating severe dry eye syndromes with autologous serum].

BACKGROUND: Dry eye syndrome with tear deficiency can be improved with artificial tears, which can be associated with topical anti-inflammatory agents. Autologous serum can provide the ocular surface with beneficial growth factors and vitamins. PATIENTS AND METHODS: Twenty-one patients suffering from severe dry eye due to Sjögren's syndrome were treated with 20% autologous serum for 2 Months. The Schirmer I test, break-up time, and fluorescein and lissamine green stainings were performed before and after treatment. Subjective complaints such as burning, foreign body sensation, dryness and photophobia were assessed by a questionnaire as well as a face score reflecting the current condition of patients' eyes. RESULTS: Lissamine green and fluorescein scores improved significantly as well as subjective symptoms of burning, foreign body sensation and dryness (p<0.05). The face score was significantly improved. Bacterial culture of serum delivered to the patients all remained negative. DISCUSSION: Autologous serum provides growth factors and vitamins that are useful for an altered ocular surface due to Sjögren's disease. However, some problems still remain: risk of contamination, arbitrary dilution of autologous serum, and a current lack of regulations for use of autologous serum. A close collaboration between ophthalmologists and the Etablissement Français du Sang (French Blood Bank) is mandatory because autologous serum should be considered as a useful tool to treat severe ocular surface disorders. CONCLUSION: The use of autologous serum improved symptoms and objective signs caused by severe Sjögren's syndrome. Currently, a lack of clear regulations prevents its widespread use in severe ocular surface disorders.

Blood Transfusion, Autologous↗
PubMed2004

[Repeated pulse corticosteroid therapy in Vogt-Koyanagi-Harada disease. A case report].

Vogt-Koyanagi-Harada disease is an autoimmune bilateral uveitis that occurs in people with genetic sensitivity. Diagnosis was based on the association of ocular inflammatory manifestations such as diffuse choroiditis, with or without anterior uveitis, and extraocular manifestations such as meningismus, tegumentary or auditory findings. Intravenous pulses of corticosteroid followed by oral corticosteroid is the mainstay therapy. We present the case of a woman who showed a first improvement of symptoms with three consecutive daily pulses of corticosteroid, but none during the following oral therapy. A second phase of intravenous pulses of corticosteroid, a Month after the first one, induced great improvement in symptoms and retinal findings, whereas oral therapy seemed not to be effective. This case provides the opportunity for a discussion on the advantages of multiple pulses of corticosteroid at the acute phase of this disease, because of its vascular effects associated with anti-inflammatory effects.

Administration, Oral↗