Two Useful Photolabile Surfaces for Solid-Phase Synthesis.
o-Nitrobenzyl-based photolabile surfaces 3 and 4 have been synthesized from 2-phenylcyclohexanone and aminopropylsiloxane-grafted controlled pore glass. The procedures are simple and inexpensive and generate materials whose minimally functionalized reactive chromophore should tolerate a range of subsequent chemistries. Time- and solvent-dependent analysis of photodegradation demonstrates a performance comparable to related photolabile systems.
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