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Pablo Artal

Publications and source records attributed to Pablo Artal.

12 recordsLinked to original sources

Aberro-polariscope for the human eye.

We have developed an aberro-polariscope that simultaneously measures spatially resolved polarization properties and wave-front aberration in a living human eye. The setup consists of an infrared Hartmann-Shack sensor that incorporates a polariscope. A series of four Hartmann-Shack images corresponding to independent polarization states were recorded. The corresponding wave-front aberration was computed from each image. Moreover, from each set of four images spatially resolved (over the pupil plane) parameters of polarization were also determined. This instrument allows useful information on both the optical and the biomechanical properties of the eye to be obtained.

Adult↗

Spatially resolved wavefront aberrations of ophthalmic progressive-power lenses in normal viewing conditions.

PURPOSE: To measure the wavefront aberration at different locations in progressive-power lenses (PPL's) isolated and in situ (PPL's plus eye). METHODS: A Hartmann-Shack wavefront sensor was used to measure progressive-power lenses and human eyes either independently or in combination. In each selected zone, the lens was placed and tilted accordingly to simulate natural viewing conditions. We measured 21 relevant locations across an isolated PPL (plano lens of power addition of 2 D). In six of the locations, the wavefront aberration of the eye plus PPL were obtained in two ways: (1) by direct measurement of the system and (2) by adding the individual wavefront aberrations of the eye and the lens for each appropriate zone. In every case, we obtained the wavefront aberration as Zernike polynomials expansions, the root mean square error, the point-spread function, and the Strehl ratio. RESULTS: Along the corridor of the PPL, third-order coma and trefoil, and astigmatism were the dominant aberrations. In areas of the PPL outside the corridor, astigmatism increased, whereas other aberrations remained similar to the lens center. Small differences were found between the direct and calculated methods used to obtain the wavefront aberration of the eye with the lens, and the possible sources of errors were discussed. In some lenses zones, the aberrations of the lens may be compensated by the particular aberrations of the eye, yielding improved optical performance over that present in the lens alone. CONCLUSIONS: We designed and built a wavefront sensor to perform spatially resolved aberration measurements in ophthalmic lenses, in particular in PPL's, either isolated or in combination with the eye. The aberrations appearing in the PPL were compared with those in normal aged eyes.

Adult↗

Corneal optical aberrations and retinal image quality in patients in whom monofocal intraocular lenses were implanted.

OBJECTIVES: To compare retinal image quality and optical corneal aberrations in patients in whom monofocal polymethyl methacrylate intraocular lenses (IOLs) were implanted with those in healthy subjects of a similar older age (60-70 years old) and to use the results to suggest improved optical designs of IOLs to maximize retinal image quality. METHODS: A double-pass apparatus was used to measure retinal image quality for 3-, 4-, and 6-mm pupil diameters. Corneal aberrations for a 4-mm pupil were calculated by a ray-tracing technique from the elevations provided by corneal topography. Two groups of 20 subjects of a similar older age were studied: in one group, polymethyl methacrylate monofocal IOLs were implanted; and in a second group, healthy subjects were used as a reference. RESULTS: The average retinal image quality was similar in older healthy patients and in patients in whom IOLs were implanted, with both groups having a significantly worse image quality than healthy younger subjects (aged 20-30 years). Both groups were more tolerant to defocus than younger subjects. CONCLUSIONS: The average retinal image quality of patients in whom IOLs were implanted was worse than that of healthy younger subjects despite the good optical quality of isolated IOLs. This apparent paradox can be understood by the nature of the aberration coupling in the eyes that undergo implantation. The ideal substitute for the natural lens is not an IOL with the best-isolated optical performance, but rather one designed to compensate for the aberrations of the cornea-a design somehow inspired by the crystalline lens of younger subjects.

Aged↗

Ocular wave-front aberration statistics in a normal young population.

Monochromatic ocular aberrations in 108 eyes of a normal young population (n=59) were studied. The wave-front aberration were obtained under natural conditions using a near-infrared Shack-Hartmann wave-front sensor. For this population and a 5 mm pupil, more than 99% of the root-mean square wave-front error is contained in the first four orders of a Zernike expansion and about 91% corresponds only to the second order. Comparison of wave-fronts aberrations from right and left eye in 35 subjects, showed a good correlation between most of the second- and third-order terms and a slight (but not clear) tendency for mirror symmetry between eyes.

Adaptation, Ocular↗

Correlation between optical and psychophysical parameters as a function of defocus.

PURPOSE: To evaluate how ocular optical image quality and psychophysical estimates of visual performance compare to each other as a function of defocus. METHODS: We measured the optical modulation transfer function using a double-pass apparatus and psychophysical estimates of visual performance: contrast sensitivity function (CSF) and visual acuity. Both sets of data were obtained under the same optical conditions. RESULTS: We measured optical and psychophysical parameters as a function of defocus. We studied the correlation between optical parameters (Strehl ratio and the logarithm of the volume in the double-pass image [log_Vol D-P]) and psychophysical parameters (the area under the fitted CSF represented in a logarithmic scale with the spatial frequency in linear scale [Area CSF-log_lin] and visual acuity) for different values of defocus. CONCLUSIONS: Strehl ratio is well correlated with the psychophysical estimates of the visual performance for moderate amount of defocus (within 1 D), whereas the other parameter (log_Vol D-P) is well correlated for larger ranges of defocus (within 2 D) and for different pupil diameters. These results suggest that optical measurements could be used for clinical testing of ophthalmic optics.

Adult↗

Contribution of the cornea and internal surfaces to the change of ocular aberrations with age.

We studied the age dependence of the relative contributions of the aberrations of the cornea and the internal ocular surfaces to the total aberrations of the eye. We measured the wave-front aberration of the eye with a Hartmann-Shack sensor and the aberrations of the anterior corneal surface from the elevation data provided by a corneal topography system. The aberrations of the internal surfaces were obtained by direct subtraction of the ocular and corneal wave-front data. Measurements were obtained for normal healthy subjects with ages ranging from 20 to 70 years. The magnitude of the RMS wave-front aberration (excluding defocus and astigmatism) of the eye increases more than threefold within the age range considered. However, the aberrations of the anterior corneal surface increase only slightly with age. In most of the younger subjects, total ocular aberrations are lower than corneal aberrations, while in the older subjects the reverse condition occurs. Astigmatism, coma, and spherical aberration of the cornea are larger than in the complete eye in younger subjects, whereas the contrary is true for the older subjects. The internal ocular surfaces compensate, at least in part, for the aberrations associated with the cornea in most younger subjects, but this compensation is not present in the older subjects. These results suggest that the degradation of the ocular optics with age can be explained largely by the loss of the balance between the aberrations of the corneal and the internal surfaces.

Adult↗

Influence of Stiles-Crawford apodization on visual acuity.

The Stiles-Crawford effect (SCE) of the first kind has often been considered to be important to spatial visual performance in that it ameliorates the influence of defocus and aberrations. We investigated the influence of SCE apodization on visual acuity as a function of defocus (out to +/-2 D) in four subjects. We used optical filters, conjugate with the eye's entrance pupil, that neutralized or doubled the existing SCE. With an illiterate-E task, the influence of the SCE was more noticeable for myopic defocus than for hypermetropic defocus, was generally more noticeable for high-contrast than for low-contrast letters, and increased with increase in pupil size. The greatest influence on visual acuity of neutralizing the SCE, across the subjects and range of conditions, was deterioration of 0.06 (4-mm pupil), 0.16 (6-mm pupil), and 0.29 log unit (7.6-mm pupil).

Contrast Sensitivity↗

Peripheral refractive errors in myopic, emmetropic, and hyperopic young subjects.

To gain more insight into the relationship between foveal and peripheral refractive errors in humans, spheres, cylinders, and their axes were binocularly measured across the visual field in myopic, emmetropic, and hyperopic groups of young subjects. Both automated infrared photorefraction (the "PowerRefractor"; www. plusoptix.de) and a double-pass technique were used because the PowerRefractor provided extensive data from the central 44 deg of the visual field in a very convenient and fast way. Two-dimensional maps for the average cross cylinders and spherical equivalents, as well as for the axes of the power meridians of the cylinders, were created. A small amount of lower-field myopia was detected with a significant vertical gradient in spherical equivalents. In the central visual field there was little difference among the three refractive groups. The established double-pass technique provided complementary data also from the far periphery. At 45 deg eccentricity the double-pass technique revealed relatively more hyperopic spherical equivalents in myopic subjects than in emmetropic subjects [+/-2.73 +/- 2.85 D relative to the fovea, p < 0.01 (+/- standard deviation)] and more myopic spherical equivalents in hyperopic subjects (-3.84 +/- 2.86 D relative to the fovea, p < 0.01). Owing to the pronounced peripheral astigmatism, spherical equivalents (refractions with respect to the plane of the circle of least confusion) became myopic relative to the fovea in all three groups. The finding of general peripheral myopia was unexpected. Its possible roles in foveal refractive development are discussed.

Adult↗

Are optical aberrations during accommodation a significant problem for refractive surgery?

PURPOSE: To study the limits to a perfect ideal customized wavefront correction due to the change of aberrations during accommodation. METHODS. We measured the dynamic changes of ocular aberrations during accommodation in normal eyes with a real-time Hartmann-Shack wavefront sensor. Those results were used in computer simulations to predict the benefit of a perfect customized correction. RESULTS: Due to the continuous changes of the aberrations over time, an ideal perfect static correction will not provide stable aberration-free optics. For example, when the eye accommodates to near objects, due to the changing aberrations, the eye will become aberrated again. An alternative correction using the aberration pattern for a slightly accommodated condition could provide a better-correction in a larger accommodative range, although at the cost of non-perfect correction for far vision. CONCLUSIONS: Due to the dynamic nature of ocular optics, a static perfect correction, for instance performed in customized refractive surgery, would not remain perfect for every condition occurring during normal accommodation.

Accommodation, Ocular↗

Aberration generation by contact lenses with aspheric and asymmetric surfaces.

PURPOSE: We explored the potential of aberration correction in the human eye by using a new generation of soft contact lenses with aspheric and asymmetric surfaces. METHODS: Soft contact lens samples were designed with one asymmetrical surface (front) and one spherical (back) to produce predetermined amounts of desired pure defocus, astigmatism, trefoil, coma, and spherical aberration. Contact lens wavefront aberrations were measured ex vivo using a Fizeau-Tolanski interferometer and compared with the in vivo wavefronts obtained by subtracting the aberrations of the eye with and without the contact lenses. These second set of measurements were obtained using a Shack-Hartmann sensor. RESULTS: We found that an aberration-free contact lens sample induced in the eye a small amount of residual aberration. We obtained a good match between the ex vivo and in vivo wavefront measurements for most of the samples of the contact lenses. CONCLUSIONS: The aberrations generated by soft contact lenses on the eye were predictable. Rotations and translations of the contact lenses with respect to correct position on the eye were, however, the main limitation for precise correction of the ocular aberrations.

Adult↗

Adaptive optics visual simulator.

PURPOSE: To develop a prototype instrument that uses adaptive optics to introduce virtually any desired aberration profile in a subject's eye. At the same time, the instrument could be used to evaluate the subject's spatial vision for each controlled aberration profile. This "aberration testing station" or "visual simulator" allows us to study the relationship between specific aberrations and visual quality. METHODS: The apparatus uses infrared light to measure the wavefront aberration of the system plus the eye with a Hartmann-Shack wavefront sensor. Defocus is added (or removed) with a computer-controlled, motorized optometer, while higher order aberrations are introduced by a 37-channel membrane deformable mirror. A parallel viewing channel is used for visual testing with the instrument. Visual acuity, contrast sensitivity, and other visual tests are performed under normal viewing for each desired aberration profile. RESULTS: The range of defocus that can be added is nearly unlimited, while the maximum amount of other aberration modes is restricted to approximately 0.5 microm, depending on mode. Pure modes or any selected combination of modes can be produced with high repeatability and precision (usually better than 0.05 microm), and the system works for pupil diameters up to 6 mm (with a natural pupil). CONCLUSIONS: The adaptive optics visual simulator is a powerful, non-invasive tool to evaluate how aberrations affect vision. In addition, it can be used for the interactive design and testing of new ophthalmic devices, and for the simulation of visual outcomes in customized refractive surgery.

Astigmatism↗