Biomedical subjects

Pamela Banta Lavenex

Publications and source records attributed to Pamela Banta Lavenex.

5 recordsLinked to original sources

PubMed2007

Postnatal development of the primate hippocampal formation.

The hippocampal formation is a multicomponent region of the medial temporal lobe preferentially involved in declarative and relational memory processing. Behavioral studies have suggested a protracted functional maturation of these structures in primates, and postnatal developmental abnormalities in the hippocampal formation are thought to contribute to neurodevelopmental disorders, such as autism, schizophrenia, epilepsy and Down syndrome. Despite all that we know about the functional organization of the adult hippocampal formation, notably absent is a systematic study of its postnatal maturation in primates. In this article, we review current knowledge of the structural development of the primate hippocampal formation and present new data on its postnatal neuroanatomical development. We summarize what is known about the neurobiological processes, such as the addition of new neurons, the establishment and elaboration of connectivity, and the neurochemical changes, that underlie the structural development and functional maturation of the primate hippocampal formation. We conclude that there is yet insufficient information to identify distinct developmental windows during which different hippocampal regions undergo specific maturational processes. For this reason, it is currently impossible to determine the ages at which specific hippocampal circuits become structurally mature and potentially capable of supporting defined, age-specific functional processes. Together with work in rodents, systematic studies of the structural development and functional maturation of the monkey hippocampal formation will be necessary to gain insight not only into the types of information processing that it subserves, but also into the specific maturational processes that might be affected in human neurodevelopmental disorders.

Aging↗

PubMed2006

Spatial relational learning persists following neonatal hippocampal lesions in macaque monkeys.

The hippocampus is important for the acquisition of spatial representations of the environment and consequently in contextual memory. This suggests that the neural substrates underlying spatial cognition might be essential for remembering specific life episodes. Indeed, hippocampal lesions prevent spatial relational learning in adult rodents and monkeys, and result in profound amnesia in adult humans. In contrast, we show here that monkeys with neonatal hippocampal lesions learned new spatial relational information. Our experiments suggest that early hippocampal damage leads to functional brain reorganization that enables spatial information to be acquired through the use of brain regions that normally do not subserve this function.

Adaptation, Physiological↗

PubMed2006

Hippocampal lesion prevents spatial relational learning in adult macaque monkeys.

The role of the hippocampus in spatial learning and memory has been extensively studied in rodents. Comparable studies in nonhuman primates, however, are few, and findings are often contradictory. This may be attributable to the failure to distinguish between allocentric and egocentric spatial representations in experimental designs. For this experiment, six adult monkeys received bilateral hippocampal ibotenic acid lesions, and six control subjects underwent sham surgery. Freely moving monkeys then foraged for food located in two arrays of three distinct locations among 18 locations distributed in an open-field arena. Multiple goals and four pseudorandomly chosen entrance points precluded the monkeys' ability to rely on an egocentric strategy to identify food locations. Monkeys were tested in two conditions. First, local visual cues marked the food locations. Second, no local cues marked the food locations, so that monkeys had to rely on an allocentric (spatial relational) representation of the environment to discriminate these locations. Both hippocampal-lesioned and control monkeys discriminated the food locations in the presence of local cues. However, in the absence of local cues, control subjects discriminated the food locations, whereas hippocampal-lesioned monkeys were unable to do so. Interestingly, histological analysis of the brain of one control monkey whose behavior was identical to that of the experimentally lesioned animals revealed a bilateral ischemic lesion restricted to the hippocampus. These findings demonstrate that the adult monkey hippocampal formation is critical for the establishment or use of allocentric spatial representations and that selective damage of the hippocampus prevents spatial relational learning in adult nonhuman primates.

Animals↗

PubMed2006

Spatial relational memory in 9-month-old macaque monkeys.

This experiment assesses spatial and nonspatial relational memory in freely moving 9-mo-old and adult (11-13-yr-old) macaque monkeys (Macaca mulatta). We tested the use of proximal landmarks, two different objects placed at the center of an open-field arena, as conditional cues allowing monkeys to predict the location of food rewards hidden in one of two sets of three distinct locations. Monkeys were tested in two different conditions: (1) when local visual cues marked the two sets of potentially baited locations, so that monkeys could use both local and spatial information to discriminate these locations from never-baited locations; and (2) when no local visual cues marked the two sets of potentially baited locations, so that monkeys had to rely on a spatial relational representation of the environment to discriminate these locations. No 9-mo-old or adult monkey associated the presence of the proximal landmarks, at the center of the arena, with the presence of food in one set of three distinct locations. All monkeys, however, discriminated the potentially baited locations in the presence of local visual cues, thus providing evidence of visual discrimination learning. More importantly, all 9-mo-old monkeys tested discriminated the potentially baited locations in absence of the local visual cues, thus exhibiting evidence of spatial relational learning. These findings indicate that spatial memory processes characterized by a relational representation of the environment are present as early as 9 mo of age in macaque monkeys.

Age Factors↗

PubMed2004

Nonphosphorylated high-molecular-weight neurofilament expression suggests early maturation of the monkey subiculum.

We analyzed the distribution of nonphosphorylated high-molecular-weight neurofilaments (NF-H) in the hippocampal formation of infant (3-week-old and 3-month-old) and adult (9-17-year-old) macaque monkeys in order to obtain neuroanatomical evidence of the maturity of these structures shortly after birth. We employed the monoclonal antibody SMI-32, a well-characterized antibody raised against nonphosphorylated NF-H, the expression of which is believed to reflect the maturation of certain neuronal populations. Patterns of SMI-32 immunoreactivity differed dramatically between infant and adult monkeys. In adults, nonphosphorylated NF-H expression was prominent in the CA3 and CA2 fields of the hippocampus, in the subiculum and in the entorhinal cortex. In infants, only the subiculum stained heavily for nonphosphorylated NF-H. These findings suggest that different subregions of the primate hippocampal formation mature at different times during development. The subiculum, the major source of efferent projections from the hippocampal formation toward subcortical structures, matures early during development. In contrast, the entorhinal cortex, the main interface of the hippocampal formation with the neocortex, matures relatively later. These findings have direct implications for the type of information processing that might be subserved by the primate hippocampal formation shortly after birth, as well as for the emergence of particular behavioral and memory processes during postnatal development.

Aging↗