Biomedical subjects
Publications and source records attributed to Patrícia Pinto.
The lung-kidney syndrome is characterized by the coexistence of glomerulonephritis and pulmonary hemorrhage. However these manifestations can define different pathologies. The association of diffuse pulmonary hemorrhage, glomerulonephritis and circulating anti-glomerular basement membrane antibodies define Goodpasture syndrome. We report a case of Goodpasture syndrome with review of the literature.
Leflunomide (LEF) is a prodrug that is rapidly converted to its active metabolite A77 1726, that inhibits the novo pyrimidine nucleotide biosynthesis, mediated especially by the dihydroorotate dehidrogenase (DHODH). DMARD properties were documented in rheumatoid arthritis with efficacy, safety and limiting of radiological progression demonstrated in multiple studies. LEF has been also used in other autoimmune diseases, like Psoriatic Arthritis, Wegener granulomatosis, Systemic Lupus Erythematosus, Sarcoidosis and others. This article reviews the place of LEF in clinical practice and outlines its potential applications beyond the officially recognized indication: rheumatoid arthritis (RA).