Biomedical subjects

Patricia Carrascosa

Publications and source records attributed to Patricia Carrascosa.

4 recordsLinked to original sources

PubMed2006

Detection of transplant coronary artery disease using multidetector computed tomography with adaptative multisegment reconstruction.

OBJECTIVES: This study sought to determine whether multidetector computed tomography (MDCT) may be able to detect occlusive coronary disease in transplanted hearts. BACKGROUND: In heart transplant recipients, asymptomatic coronary disease requiring frequent surveillance commonly develops. Recent advancements in MDCT allow for noninvasive assessment of the coronary vessels. METHODS: Electrocardiogram-gated contrast-enhanced MDCT scans (16 x 0.75-mm detectors, 420 ms rotation, 100 ml contrast) with multisegment reconstruction were performed on 54 transplant recipients within 6 +/- 11 days of quantitative coronary angiography (QCA). Heart rate at the time of the scan was 90 +/- 11 beats/min. Coronary arterial segments >1.5 mm in diameter were analyzed by independent investigators. RESULTS: There was a good correlation between MDCT and QCA percent stenosis (r = 0.75, p < 0.01, SEE = 15%). Of the 791 segments identified by QCA, 754 (95%) were analyzable by MDCT. The sensitivity, specificity, and positive and negative predictive values of MDCT compared with QCA for the detection of segments with significant (>50%) stenosis were 86%, 99%, 81%, and 99%, respectively. The MDCT correctly identified 15 of the 16 (94%) transplant patients classified by QCA as having occlusive coronary artery disease and 29 of the 37 patients without significant stenosis (78%). In 1 patient who received intravenous beta-blockers, transient bradycardia requiring temporary pacing developed, but there were no other complications. CONCLUSIONS: Detection of occlusive coronary disease in heart transplant recipients with elevated resting heart rate by MDCT is feasible using multicycle reconstruction. The need for surveillance invasive coronary angiography in transplant recipients might be mitigated by use of MDCT.

Adult↗

PubMed2003

[Virtual Colonoscopy. Experience in 500 patients].

OBJECTIVE: To show our experience and results in Virtual Colonoscopy (VC). MATERIAL AND METHOD: Five hundred patients with personal or familial history of colorectal carcinoma and/or adenomas, or any kind of coloproctologic symptoms were studied. VCs were practiced using a helical CT scanner (300 patients) and a multislice CT scanner (200 patients) a few hours after Conventional Colonoscopy (CC), considered the gold standard. The patients were evaluated in a prospective blind study, to determine sensitivity and specificity of VC. Findings were classified as: 1) normal studies; 2) studies with pathological findings. This one was subdivided into: 2a) Lesions below 5 mm., 2b) Lesions between 5-9 mm., 2c) Lesions above 9 mm. RESULTS: VC detected 253 normal studies whereas CC only detected 233. The sensitivity and specificity for each subgroup were: 2a) 87.8% and 86.9%; 2b) 95.6% and 91.4%; 2c) 100.0% and 100.0% respectively. CONCLUSION: VC is a feasible and useful method for evaluating the entire colon. It is well tolerated, it has no complications and a high sensitivity and specificity for elevated lesions, especially the ones above or equal to 5 mm.

Adult↗

PubMed2002

[Virtual gastroscopy. Preliminary experience].

OBJECTIVE: To define the role of virtual gastroscopy (VG) in the detection of elevated lesions comparing its results with conventional endoscopy (CE) as the gold standard method. MATERIALS AND METHODS: Between December 2000 and July 2001, 19 patients were evaluated. The age ranged between 41 and 72 (mean 58.8 years old). VG and CE were performed in all the patients during the same week. VG were carried out with a multislice CT scanner (Mx 8000, Marconi Medical Systems). The technical parameters used were 3 mm with slices and 1.5 mm reconstruction intervals. The acquisition time was 22 seconds. Images were sent to a workstation (MxView, Marconi Medical Systems) where they were reprocessed in three different ways: 1) Bidimensionally 2) Tridimensionally 3) Virtual Endoscopy Findings of VG were compared with CE. RESULTS: VG detected 39 lesions, whereas CE detected 40 lesions. There were 39 true-positive findings, 2 true-negative findings, 0 false-positive findings and 1 false-negative findings. The Sensitivity (Se) was 97.5%; Specificity (Sp) was 100%, positive predictive value 100% and Negative predictive value 66%. CONCLUSIONS: VG is a new non-invasive method with high Se and Sp in the detection of elevated lesions. The actual role of VG consist in identification of gastric lesions and possibility to diagnose gastric disease.

Adult↗

PubMedDate not supplied

Multidetector CT colonoscopy: evaluation of the perspective-filet view virtual colon dissection technique for the detection of elevated lesions.

BACKGROUND: The purpose of our study was to determine the usefulness of a virtual computed tomography colon dissection visualization technique for the detection of polypoid lesions in comparison with conventional virtual colonoscopy analysis and optical colonoscopy. METHODS: Twenty-three patients were evaluated with optical colonoscopy and computed tomography colonoscopy using 16-row MDCT on the same day. CT images were analyzed by the colon dissection workup with unfolded haustra visualization and also using the conventional virtual colonoscopy technique (axial images and endoluminal views). The CT analysis was performed by an experienced radiologist using both viewing methods in a randomized order and blinded to optical colonoscopy results. RESULTS: Optical colonoscopy revealed 35 colonic lesions; 15 < 5 mm, 18 between 5-9 mm and 2 > 9 mm. For conventional virtual colonoscopy analysis the overall sensitivity was 86.67%; for the colon dissection visualization technique, the overall sensitivity was 82.86%. The average reading time for conventional virtual colonoscopy was 15 +/- 3 vs. 8 +/- 2 min for the colon dissection visualization technique. CONCLUSIONS: Our results showed that there is a significant reduction in the reading time using the colon dissection visualization technique without detriment to the detection rate, that is, competitive to conventional virtual colonoscopy interpretation results.

Adult↗