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Biomedical subjects

Patricia Deldin

Publications and source records attributed to Patricia Deldin.

4 recordsLinked to original sources
PubMed2006

Normal N400 in mood disorders.

Individuals diagnosed with major depression have been characterized as having a variety of cognitive problems based on a number of behavioral and psychophysiological measures, but it is not clear whether there is a consistent language processing abnormality in depression. Three studies sought to determine whether diverse mood disordered samples show abnormal semantic processing, as indexed by a failure to show increased N400 event-related brain potential amplitudes to passively viewed incongruent, relative to congruent sentence endings. Individuals with major depression (N = 50) or dysthymia (N = 14) had N400 amplitudes similar to those of controls (N = 41) in this sentence processing paradigm. These results are consistent with a small behavioral literature suggesting intact semantic processing in depression and further indicate that abnormal controlled processing in some tasks does not simply reflect a generalized deficit.

Adult↗
PubMed2004

Contingent negative variation to emotional in- and out-group stimuli differentiates high- and low-prejudiced individuals.

Low- and high-prejudiced individuals exhibited differential cortical and behavioral responses to the pending and actual evaluation of emotional in- and out-group faces. Participants viewed warning stimuli indicating the subsequent presentation of an angry or happy African-American or Caucasian face. Upon presentation of the face, participants judged whether they would enjoy working with the individual. The contingent negative variation (CNV ) component of the event-related potential in response to the pending presentation of in- and out-group emotional stimuli distinguished low- from high-prejudiced individuals. Specifically, low-prejudiced individuals showed greater early CNV in anticipation of angry African-American targets, and increased reaction time to evaluating these faces. High-prejudiced individuals showed decreased early CNV in anticipation of angry African-American faces, accompanied by decreased response latencies, and enhanced CNV in anticipation of happy Caucasian faces. Notably, no group differences emerged in either the pending or actual evaluation of happy out-group faces. The data are discussed with regard to implications for understanding the nature of prejudice, and underscore both the importance of emotional expression on how a target is appraised and also the utility of using converging measures to clarify processes that may contribute to social behavior.

Black or African American↗
PubMed2004

A CNV-distraction paradigm in combat veterans with posttraumatic stress disorder.

Fourteen veterans with posttraumatic stress disorder (PTSD) and 14 without PTSD participated in a contingent negative variation (CNV)-distraction paradigm. Subjects were instructed to press a button after hearing a high-pitched tone (S2) preceded by a low-pitched tone (S1). One-half of the trials included a white-noise distracter placed in the S1-S2 interval. Posttraumatic stress disorder subjects had larger frontal, but smaller central and parietal CNVs, regardless of condition (distracter, no distracter) or epoch (early CNV, late CNV). In PTSD subjects, the N1/P2 complex was smaller to warning (S1) and distracter stimuli and did not show the extent of facilitation present in non-PTSD subjects. Findings highlight PTSD-related differences in phasic cortical excitability and attention.

Acoustic Stimulation↗