Biomedical subjects

Patricia Montero Mora

Publications and source records attributed to Patricia Montero Mora.

7 recordsLinked to original sources

PubMedDate not supplied

[Common variable immunodeficiency. Report of 2 cases].

We report two cases with common variable immunodeficiency. Both of them had gammaglobulin concentration lower than 300 mg/dL and evolved differently. The first one had three pneumonic episodes that responded satisfactorily to antibiotics. Today, this patient presents only two or three sinusitis clinical schemes per year, and has a good response to treatment. The second one has a bad evolution and presents hematological problems like thrombocytopenia and neutropenia. She also suffers lymphoid nodular hyperplasia in the intestinal tract and atrophy in the intestinal. These cases illustrate the wide clinical, immunological and genetic variety of the syndrome.

Anti-Bacterial Agents↗

PubMedDate not supplied

[Remodeling in asthma: review of the literature].

Remodeling, understood as a new or different reconstruction, has been observed in every organ after a chronic inflammatory response. In allergy, it has very important clinical consequences. As an example, in asthma this process is responsible for functional deterioration. In this case, the myofibroblasts play a central role in the process, together with a succession of products that are involved. In this bibliographic review we analyze the most important factors.

Asthma↗

PubMedDate not supplied

[Nasal remodeling in patient with perennial allergic rhinitis].

BACKGROUND: Remodeling is considered a new or different reconstruction of tissues. The airway remodeling is a consequence of changes induced by endothelial cells and extra-cellular matrix as a result of chronic inflammation. OBJECTIVE: To show histological changes into mucosa in patients with perennial allergic rhinitis. MATERIAL AND METHODS: We studied 26 patients with perennial allergic rhinitis, with evolution of 3 to 6 years, between 20 to 40 years old, without medical or immunological treatment. A turbinate biopsy was taken in all of them. RESULTS: We found enlargement of the basal membrane in 92.3%, subepithelial fibrosis in 92.4%, neutrophils in 100% of the cases, eosinophils in 100%, lymphocytes in 100%, edema in 46.2%, fragmented reticular fibers in 19.2%, and vascular dilatation in 11.1%. CONCLUSION: These results suggest nasal remodeling in patients with allergic rhinitis, although more structural studies about this pathology are necessary.

Adult↗

PubMedDate not supplied

[HIV-infection and its implications on allergic diseases].

INTRODUCTION: In 1980 AIDS appeared in the USA in the homosexual community. CHARACTERISTICS OF THE VIRUS: A particle of HIV is formed by two identical RNA chains that are packed within a center of viral proteins, and surrounded by a double layer of fosfolipids derived from the cellular membrane of the host. CLINICAL SYMPTOMS: It starts with a severe infection, evolving in a progressive chronic infection reaching a final phase with a T CD4+ cellular count under 200 cells per mm3, with incident infections, neoplasias, consumption syndrome, renal dysfunction, and degeneration of the central system. CONSEQUENCES IN ALLERGIC REACTION: Reactions to the use of drugs are the most frequent form of hypersensitivity caused by HIV compared to the general population. In this condition, a profile of TH2 cytocines are produced and they induce the synthesis of IgE against the drugs. IgE levels have been related to the progression of this condition. CONCLUSION: The increase of IgE is a risk factor to allergic reactions against these medications, as well as a severity index.

HIV Infections↗

PubMedDate not supplied

[Autoimmune urticaria. Treatment with methotrexate].

BACKGROUND: It has been established that 27-50% of patients with idiopathic chronic urticaria have antibodies directed against the alpha chain of the high-affinity IgE receptor, which are indirectly detected by cutaneous tests with autoserum. Thus, an autoimmune urticaria diagnosis can be settled. OBJECTIVE: To prove methotrexate's efficiency in patients with autoimmune urticaria. MATERIAL AND METHODS: Seven patients took part in the study. A series of tests was performed in order to rule out any possible infectious, metabolic, or physical etiology. Initial treatment with methotrexate with doses of 2.5 mg every 12 hours, two days a week was provided. In case there were no toxicity data, doses would increase to three days a week for a 6-week period. RESULTS: Statistically significant improvement was observed in the itching, as well as the presence of spots, repercussion on daily activities, sleep disorders. There was no statistical difference regarding the extension of the lesions and the presence of angioedema. Adverse effects were not significant. CONCLUSION: We conclude that methotrexate is effective in the treatment of autoimmune urticaria.

Acetates↗

PubMedDate not supplied

[Therapeutic options in idiopathic chronic urticaria].

BACKGROUND: Chronic idiopathic urticaria is a clinic entity that is manifested by wheals of more than six weeks of evolution, without identification of the causing agent, and sometimes resistant to conventional treatment. There are improvements with leukotriene receptor antagonists. OBJECTIVE: To evaluate the clinical efficacy of montelukast and desloratadine individually and combined, compared with hydroxicine. PATIENTS AND METHODS: The trial included 40 subjects with chronic idiopathic urticaria referred from the outpatient allergy service. They were randomly divided into four groups to receive: hydoxicine, montelukast, montelukast plus desloratadine, and desloratadine alone during six weeks. The assessments compared the first and sixth weeks. RESULTS: All therapeutic options are effective, with statistical significance, highlighting that the new therapeutic modes are safe and have better resolution of lesions and symptoms. CONCLUSIONS: All the alternatives are viable, considering they are adjusted to each patient, adverse symptoms, socio-economic status and clinical severity.

Acetates↗

PubMedDate not supplied

[Reactions to drugs. A review of literature].

Adverse drug reactions are originated by immunological and non-immunological mechanisms. Estimated incidence is of 6.7%, and the incidence of mortal reactions is of 0.32%. In women, skin reaction incidence is 35% higher than in men, and it is 20 times higher than presenting contrast medium-related reactions. Allergic reaction is classified accordingly to Gell and Coombs criteria. It is unknown the pathogenic mechanism of the drug-induced fever. Predictable reaction depends on the dose and it is frequently related to the drug. Unpredictable reaction depends on the individual and pseudoallergic features of each patient; no immunological mechanism is involved. For diagnosis, lymphocyte transformation test measures the T cell proliferation to an in vitro drug; furthermore, it is the most sensitive. There are just a few options to evaluate and manage those patients. When it is impossible to make the exposition test the alternative is to withdraw the drug and try another treatment option. If there is no other available drug, desensitization must be considered.

Dose-Response Relationship, Drug↗