Biomedical subjects

Patrick Chastanet

Publications and source records attributed to Patrick Chastanet.

3 recordsLinked to original sources

PubMed2005

Contribution of percutaneous biopsy to the definite diagnosis in patients with suspected bone tumor.

OBJECTIVES: Percutaneous biopsy is widely used for the diagnosis of primary and secondary bone malignancies. The primary objective of this study was to evaluate the contribution of percutaneous biopsy to the definite diagnosis in patients with suspected bone tumor. The secondary objective was to assess the potential diagnostic benefits of a second percutaneous biopsy when the first failed to provide the diagnosis. METHODS: We retrospectively reviewed 108 percutaneous biopsies of bone lesions in 89 patients admitted to our rheumatology department from January 1994 to December 2001. There were 61 men and 28 women with a mean age of 59 years. The biopsies were done under computed tomography guidance in 68 patients and fluoroscopy in 21 patients. RESULTS: The diagnostic yield of percutaneous biopsies was 68.5% overall and was significantly higher in patients with metastatic bone disease (100%) than in patients with primary tumors (83%) or hematological malignancies (58%) (P = 0.0004 and P < 0.0001, respectively). Yields were higher for peripheral lesions (85%) than for vertebral (65%) and pelvic (60%) lesions. Yields were 87% for lytic lesions, 66% for sclerotic lesions, and 50% for mixed lesions. When soft tissues were sampled, the yield was 100%, as compared to 86% for biopsies composed only of bone. CONCLUSION: Percutaneous biopsy of suspected bone tumors is a safe and inexpensive procedure that consistently ensures the diagnosis of bone metastases. The diagnostic yield is lowest in patients with bone lesions caused by hematological malignancies. When two biopsies fail to provide the diagnosis, further biopsies are unlikely to be helpful.

Adolescent↗

PubMed2004

Primary amyloidoma of the axis and acute spinal cord compression: a case report.

BACKGROUND: Localized primary amyloidosis is a disease characterized by a single tumor and localized amyloid deposit (amyloidoma) with no evidence of generalized amyloidosis. The occurrence of an amyloidoma in the spine is rare and only three cases affecting the axis have been previously reported. We describe the case of a 79-year-old woman presenting with a mass involving the odontoid process, responsible for an acute tetraparesia. Diagnosis of local primary amyloidosis was made after surgical excision. RESULTS: Despite the critical presentation, outcome was excellent after total excision of the mass. This case can be classified as a primary localized amyloidoma. The patient did not exhibit any infection, tumor or inflammatory disease, and continued investigations failed to demonstrate other amyloid deposit after one-year follow-up. CONCLUSIONS: Amyloidoma must be discussed in presence of a tumor-like mass of the odontoid process and may be responsible, as in our case, for spinal cord compression.

Aged↗

PubMed1997

Percutaneous Acetabular Osteoplasty.

The diagnostic value of ultrasound for musculoskeletal pathology is well recognized. Ultrasound offers a low-cost, nonionizing, readily available imaging technique for the evaluation of tendons, muscles, soft-tissue masses, cysts, and other fluid collections. These advantages also make ultrasound a valuable tool for guiding a variety of musculoskeletal interventions. Its real-time capabilities permit continuous monitoring of the needle position relative to the target lesion and to surrounding structures such as vessels. Ultrasound can be regarded as the ÒfluoroscopyÓ for soft tissues. Ultrasound therefore can be used to localize and characterize the lesion, monitor the needle position during the procedure, document the efficacy of the drainage or the technique, and be used for follow-up imaging. Procedures that can be performed under ultrasound guidance include aspiration of fluid for analysis, injection of medication (steroids), decompression of cyst, bursitis or joint, abscess and hematoma drainage, treatment of calcific tendinitis, biopsy, and foreign body retrieval.

Journal Article↗