Biomedical subjects

Patrick Meyrueis

Publications and source records attributed to Patrick Meyrueis.

3 recordsLinked to original sources

PubMed2006

Interferometric biosensor based on planar optical waveguide sensor chips for label-free detection of surface bound bioreactions.

A label free optical biosensor based on a free-space Young interferometer configuration is presented. Commercial planar Ta(2) O(5) waveguides are used as sensing elements and allow the investigation of surface bound bioreactions like immunoreactions or biological affinity systems. Design criteria are discussed and a detailed characterization of the sensor performance is presented. The developed interferometer yields an effective refractive index resolution of 9 x 10(-9), corresponding to a surface coverage of approximately 13 fg/mm(2). The performance of the system is characterized by two different affinity systems: the antibody-antigen complex protein G-immunoglobulin G is used as a model system for monitoring reaction kinetics. Further measurements on a silanized surface show the formation of a streptavidin monolayer on a biotinylated surface.

Biosensing Techniques↗

PubMed2005

Properties of a three-dimensional photonic jet.

By focusing light with a sphere several wavelengths in diameter, we can obtain a photonic nanojet [Opt. Express 13, 526 (2005)]: if light is focused on the surface of the sphere, the width of the beam stays smaller than the wavelength along a distance of propagation of approximately two wavelengths and reaches a high intensity. We use the rigorous Mie theory to analyze the basic properties of the photonic jet in the general three-dimensional polarized case. This fast algorithm allows us to determine the influence of the radius and the refractive index of the sphere on the photonic jet. The polarization response is also studied. We observe that high-intensity concentrations and subwavelength focusing are two different effects. Their basic properties are analyzed, and explanations are proposed.

Journal Article↗

PubMed2003

Fringe pattern analysis with a parametric method for measurement of absolute distance by a frequency-modulated continuous optical wave technique.

Interferometry associated with an external cavity laser of long coherence length and broad wavelength tuning range shows promising features for use in measurement of absolute distance. As far as we know, the processing of the interferometric signals has until now been performed by Fourier analysis or fringe counting. Here we report on the use of an autoregressive model to determine fringe pattern frequencies. This concept was applied to an interferometric device fed by a continuously tunable external-cavity laser diode operating at a central wavelength near 1.5 microm. A standard uncertainty of 4 x 10(-5) without averaging at a distance of 4.7 m was obtained.

Journal Article↗