Biomedical subjects

Patrick Parsons

Publications and source records attributed to Patrick Parsons.

3 recordsLinked to original sources

PubMed2006

Predictors of blood mercury levels in older urban residents.

OBJECTIVE: The objective of this study was to describe the distribution and predictors of blood mercury levels in an adult population. METHODS: This was a cross-sectional analysis of first-visit data (2001-2002) on a random sample of 474 subjects from the Baltimore Memory Study. RESULTS: After adjustment for race/ethnicity, education, assets, and diabetes, persons in the highest quartile of fish consumption had median mercury levels 1.82 times above the levels in the lowest quartile, while those in the highest education category had median mercury levels 1.57 times higher than levels in the lowest category. Nine percent of subjects were above the reference dose recommended by the Environmental Protection Agency, which is high compared with that found by the Centers for Disease Control and Prevention in women of childbearing age. CONCLUSIONS: These findings offer guidance for targeted education and possible new insights regarding the kinetics of mercury.

Aged↗

PubMed2005

Blood mercury levels and neurobehavioral function.

CONTEXT: Due to its cardiovascular benefits, fish consumption is widely encouraged among older Americans. However, this fast-growing population is at increased risk of cognitive impairment and may be particularly sensitive to methylmercury, a neurotoxicant found in fish. OBJECTIVE: To describe associations of blood mercury levels with neurobehavioral test scores in an urban adult population. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analysis to determine the effect of mercury levels on neurobehavior in 474 randomly selected participants in the Baltimore Memory Study, a longitudinal study of cognitive decline involving 1140 Baltimore residents aged 50 to 70 years. We measured total mercury in whole blood samples and used multiple linear regression to examine its associations with neurobehavioral test scores. First-visit data were obtained in 2001-2002. MAIN OUTCOME MEASURES: Twenty scores from 12 neurobehavioral tests. RESULTS: The median blood mercury level was 2.1 microg/L (range, 0-16 microg/L). After adjustment for covariates, increasing blood mercury was associated with worse performance on Rey complex figure delayed recall, a test of visual memory (beta, -0.224; 95% confidence interval, -0.402 to -0.047). However, increasing blood mercury levels were associated with better performance on finger tapping, a test of manual dexterity (beta for dominant hand, 0.351; 95% confidence interval, 0.017-0.686). CONCLUSION: Overall, the data do not provide strong evidence that blood mercury levels are associated with worse neurobehavioral performance in this population of older urban adults.

Adult↗

PubMed2004

Relationship between blood lead concentration and dietary intakes of infants from 3 to 12 months of age.

Data from a study of mother-infant pairs of low socioeconomic status living in Albany County, NY, were analyzed to determine the influence of diet and nutrition on the blood lead level of infants during the first year of life. Children's diets were assessed at 3-month intervals using a 24-h diet recall as reported by the primary caregiver. The potential impact of dietary consumption of protein, iron, zinc, calcium, vitamin D, and fat, as well as serum vitamin D and ferritin on blood lead levels at 6 and 12 months of age was examined with multivariable statistical analyses, controlling for other influences on lead levels. Neonates' blood lead levels were low at birth (geometric mean=1.6 microg/dL), and none were elevated (> or = 10 microg/dL). By 12 months, the mean blood lead for this sample was 5.1 microg/dL, and 18% of the sample had an elevated blood lead level. We observed significant inverse relationships between infants' 6-month lead level and their intake of zinc, iron, and calcium. At 12 months, low iron intake continued to be associated with higher lead levels, although zinc and calcium did not. Protein had a paradoxical effect, being associated with lower lead at 6 months, but higher lead at 12 months. Serum vitamin D and ferritin were not associated with lead levels, nor was vitamin supplement use. The results reported here emphasize the value of key minerals in the diet to reduce lead absorption during early infancy.

Diet↗