Biomedical subjects

Paulo Schiavom Duarte

Publications and source records attributed to Paulo Schiavom Duarte.

3 recordsLinked to original sources

PubMed2006

[Reference values for thyroid 24 hours 123I uptake].

To establish references for thyroid 24 h 123I uptake value (TUV), we reviewed 475 patients who had free T4 and TSH dosages, and TUV measured 24h after the administration of 123I. The patients were separated in 3 groups: hyperthyroid, euthyroid and hypothyroid, according to thyroid hormone results. The mean and standard deviation (SD) of the TUVs were calculated for each group. We used the unpaired T test to compare the means and ROC curves to evaluate the best TUV to separate the groups. The mean and SD of TUVs for the groups were: hyperthyroid (36.5% +/- 16.5%), euthyroid (14.4% +/- 5.48%) and hypothyroid (13.7% +/- 7.5%). The unpaired T test showed statistically significant difference between hyperthyroid and euthyroid groups (p < 0.01). There was no significative difference between hypothyroid and euthyroid groups (p = 0.55). The 23% TUV has the best sensitivity (80%)/specificity (93%) ratio to separate hyperthyroid from euthyroid groups. There was not a good TUV to separate euthyroid form hypothyroid groups. In conclusion, it can be established 23% as the optimal superior limit for the normal uptake values. However, it was not possible to establish a suitable inferior limit, due to the expressive overlay of TUVs of hypothyroid and euthyroid groups.

Adolescent↗

PubMed2006

Indication of myocardial perfusion scintigraphy for coronary artery disease detection based on clinical-epidemiological and treadmill test evidences.

OBJECTIVE: To establish when the myocardial perfusion scintigraphy (MPS) should be performed based on well-defined information obtained from treadmill test results and clinical-epidemiological parameters for coronary artery disease (CAD). METHODS: 2,100 patients who underwent MPS were classified according to the results of scintigraphy, the Duke score and a clinical-epidemiological score based on Framingham study. The patients with positive results on MPS were followed to define whether the results were true positives. Receiver operating characteristic (ROC) curves were used to establish the efficiency and the best Duke and clinical-epidemiological scores to define patients that should be submitted to scintigraphy. RESULTS: It was observed that the MPS use restriction in patients with Duke score below 7.5 and/or clinical-epidemiological score above 4 could decrease the utilization of this method by 50% without exposing the patients to a significant misdiagnosis risk. CONCLUSION: The utilization of the Duke score and a clinical-epidemiological score to classify the patients expressively decreased the number of unnecessarily requested scintigraphies.

Adult↗

PubMed2003

Clinical significance of transient left ventricular dilation assessed during myocardial Tc-99m sestamibi scintigraphy.

OBJECTIVE: To assess the clinical significance of transient ischemic dilation of the left ventricle during myocardial perfusion scintigraphy with stress/rest sestamibi. METHODS: The study retrospectively analyzed 378 patients who underwent myocardial perfusion scintigraphy with stress/rest sestamibi, 340 of whom had a low probability of having ischemia and 38 had significant transient defects. Transient ischemic dilation was automatically calculated using Autoquant software. Sensitivity, specificity, and the positive and negative predictive values were established for each value of transient ischemic dilation. RESULTS: The values of transient ischemic dilation for the groups of low probability and significant transient defects were, respectively, 1.01 0.13 and 1.18 0.17. The values of transient ischemic dilation for the group with significant transient defects were significantly greater than those obtained for the group with a low probability (P<0.001). The greatest positive predictive values, around 50%, were obtained for the values of transient ischemic dilation above 1.25. CONCLUSION: The results suggest that transient ischemic dilation assessed using the stress/rest sestamibi protocol may be useful to separate patients with extensive myocardial ischemia from those without ischemia.

Dilatation, Pathologic↗