Biomedical subjects

Per Olav Vandvik

Publications and source records attributed to Per Olav Vandvik.

4 recordsLinked to original sources

PubMed2006

Prevalence, comorbidity and impact of irritable bowel syndrome in Norway.

OBJECTIVE: To study the prevalence of irritable bowel syndrome (IBS) and its comorbidity in a Norwegian adult population. MATERIAL AND METHODS: In 2001, 11,078 inhabitants (aged 30-75 years) in Oppland County were invited to take part in a public health survey. A total of 4622 subjects (42%) completed the questionnaires on symptoms of IBS (Rome II criteria), comorbidity, health-care visits and medications. The impact of comorbidity on global health, working disability and use of health-care resources in subjects with IBS was explored by stepwise logistic regression. RESULTS: The population prevalence of IBS was 388/4622 (8.4% (95% CI: 7.6-9.4%)) with a female predominance and an age-dependent decrease. The proportion who had consulted for IBS ranged from 51% among 30-year-olds to 79% in 75-year-olds (p=0.05). IBS was associated with musculoskeletal complaints (OR = 2.4-3.4 for six different items), fibromyalgia (OR = 3.6 [2.7-4.8]), mood disorder (OR = 3.3 (2.6-4.3)), reduced global health (OR = 2.6 (2.1-3.2)), working disability (OR = 1.6 (1.2-2.1)), more frequent health-care visits and use of medications (OR 1.7-2.3). When controlling for comorbidity, reduced global health (OR = 1.5 (1.1-2.0)) and use of alternative health care (OR = 1.7 (1.3-2.4)) remained associated with IBS. Severity of abdominal pain/discomfort was a predictor of having to seek a physician for IBS (OR = 1.3 (1.2-1.5)). CONCLUSIONS: Symptoms of IBS were reported by 8% of Norwegian adults and had resulted in consultations with physicians for the majority in the long run. Subjects with IBS in the community were characterized by frequent somatic and psychiatric comorbidity. Their observed reduced health, working disability and increased use of health resources were largely explained by comorbid symptoms and disorders.

Adult↗

PubMed2006

Limited usefulness of non-invasive coronary angiography with 16-detector multislice computer tomography at a community hospital.

OBJECTIVES: To evaluate the usefulness of coronary angiography by 16-detector multislice spiral computed tomography (MSCT) in community hospital outpatients. DESIGN: MSCT was performed at the community hospital in 157 of 218 consecutive outpatients with suspected significant coronary disease, before referral for invasive coronary angiography. RESULTS: 101 patients had interpretable MSCT angiograms (64 men, age 62+/-10 years, calcium score 373+/-678, heart rate 56+/-7 beats/min, beta-blocker used by 91%). Coronary stenoses >50% were identified by invasive angiography in 49 patients. Only 79% of all segments could be assessed by MSCT due to heavy coronary calcification (12%) and blurred images (9%) in the remaining. By interpreting non-assessable segments as negative results 79 patients were correctly classified by MSCT. Sensitivity, specificity, positive and negative predictive values at patient level was 82%, 75%, 75% and 81%. By interpreting non-assessable segments as positive findings, the corresponding values were 100%, 29%, 57% and 100%, with correct diagnoses in 63% of patients. CONCLUSIONS: Limited diagnostic accuracy, non-interpretable scans and radiation exposure restrict the usefulness of coronary MSCT in a community hospital setting.

Aged↗

PubMed2005

[Perforated peptic ulcer--a 12-year material].

BACKGROUND: We aimed to explore patient characteristics, diagnostic and surgical procedures and results of treatment of perforated peptic ulcer at our hospital, and determine prognostic factors for death and postoperative complications. MATERIAL AND METHODS: Data were collected retrospectively from 102 patients with perforated peptic ulcer identified from a broad case file search of 590 patients from 1992 to 2003. Prognostic factors for dead and post-operative complications were analysed using both uni- and multivariate analyses. RESULTS: 48 men and 54 women, median age 71 (25 - 94) were evaluated. Surgery was performed in 100 patients, 2 received conservative treatment. 55 patients had perforated gastric ulcers (including prepyloric ulcers), and 47 patients had perforated duodenal ulcers. Out of the 100 patients who underwent surgery, 22 died and 39 suffered postoperative complications. By univariate analysis, high age, high ASA score and a long interval between initial symptoms and surgery were significantly associated with death (p < 0.01) and postoperative complications (p < 0.05). By logistic regression, high age (OR 1.1; 95 % CI 1.0 - 1.2; p = 0.04) and high ASA classification (OR 6.7; 95 % CI 1.4 - 33; p = 0.02) predicted death, and high ASA classification predicted postoperative complications (OR 4.2; 95 % CI 1.7 - 10.2; p = 0.002). INTERPRETATION: Perforated peptic ulcer is a disease with low incidence, high mortality and a high frequency of postoperative complications, mainly determined by the patient's age and ASA classification.

Adult↗

PubMed2004

Abdominal complaints in general practice.

OBJECTIVE: The study evaluates the prevalence and diagnoses of abdominal complaints in general practice, and compares characteristics and symptoms of patients with functional gastrointestinal disorders (FGIDs) and organic diseases. DESIGN: A cross-sectional study. SETTING: Nine centres with 26 participating general practitioners (GPs) in Norway. SUBJECTS: 3097 out of 3369 consecutive adult patients answered a questionnaire regarding abdominal complaints IN the last 3 months. Those who consulted for the complaints were eligible for this study. MAIN OUTCOME MEASURES: The GPs' diagnoses and patients' characteristics were reported in questionnaires. RESULTS: 460 out of 1499 patients with abdominal complaints consulted for these complaints; 392 were included in this study. The GPs diagnosed an FGID in 167 (42.6%) patients, organic disease in 145 (37.0%), and made no diagnosis in 80 (20.4%). Stress-related symptoms were a statistically significant predictor of a FGID (OR 1.95) and weight loss predicted in addition organic disease (OR 2.7) in 128 patients with a verified diagnosis. CONCLUSION: Abdominal complaints are a common problem in general practice. The distinction between FGID, which accounted for half of the diagnoses, and organic disease was difficult. The only significant predictor for FGID was stress-related symptoms.

Abdominal Pain↗