Biomedical subjects

Peter B Delahunt

Publications and source records attributed to Peter B Delahunt.

12 recordsLinked to original sources

PubMed2006

Bayesian model of human color constancy.

Vision is difficult because images are ambiguous about the structure of the world. For object color, the ambiguity arises because the same object reflects a different spectrum to the eye under different illuminations. Human vision typically does a good job of resolving this ambiguity-an ability known as color constancy. The past 20 years have seen an explosion of work on color constancy, with advances in both experimental methods and computational algorithms. Here, we connect these two lines of research by developing a quantitative model of human color constancy. The model includes an explicit link between psychophysical data and illuminant estimates obtained via a Bayesian algorithm. The model is fit to the data through a parameterization of the prior distribution of illuminant spectral properties. The fit to the data is good, and the derived prior provides a succinct description of human performance.

Algorithms↗

PubMed2006

Illusory spreading of watercolor.

The watercolor effect (WCE) is a phenomenon of long-range color assimilation occurring when a dark chromatic contour delineating a figure is flanked on the inside by a brighter chromatic contour; the brighter color spreads into the entire enclosed area. Here, we determined the optimal chromatic parameters and the cone signals supporting the WCE. To that end, we quantified the effect of color assimilation using hue cancellation as a function of hue, colorimetric purity, and cone modulation of inducing contours. When the inner and outer contours had chromaticities that were in opposite directions in color space, a stronger WCE was obtained as compared with other color directions. Additionally, equal colorimetric purity between the outer and inner contours was necessary to obtain a large effect compared with conditions in which the contours differed in colorimetric purity. However, there was no further increase in the magnitude of the effect when the colorimetric purity increased beyond a value corresponding to an equal vector length between the inner and outer contours. Finally, L-M-cone-modulated WCE was perceptually stronger than S-cone-modulated WCE for our conditions. This last result demonstrates that both L-M-cone and S-cone pathways are important for watercolor spreading. Our data suggest that the WCE depends critically upon the particular spatiochromatic arrangement in the display, with the relative chromatic contrast between the inducing contours being particularly important.

Adult↗

PubMed2006

Cone-mediated multifocal electroretinogram in age-related macular degeneration: progression over a long-term follow-up.

OBJECTIVE: To evaluate the progression of change in the cone-driven multifocal electroretinogram (mfERG) responses in patients previously identified as having high-risk, soft drusen 63 mum or greater. METHODS: Seventeen eyes of 14 patients were reevaluated after 28 to 41 months. Fundus changes were graded depending on drusen size and extent. Each of the 103 mfERG responses was analyzed and compared with age-matched normal controls and with the baseline measurement. RESULTS: Stable visual acuity was found in 12 of the 17 eyes. Drusen size or extent was increased, decreased, and unchanged in 6, 3, and 8 eyes, respectively. The mfERG responses demonstrated a significant progression in the response density loss and in N1 and P1 implicit time delay compared with the baseline evaluation regardless of drusen change. The extent of response deterioration occurred over the entire retinal area tested. Eyes having decreased drusen at follow-up were typically associated with higher response delays at baseline and follow-up than eyes with stable or increased drusen. CONCLUSIONS: Early age-related macular degeneration is associated with a progressive loss in the cone-driven mfERG response despite stable visual acuity. The response deterioration extended beyond the visible drusen area. Implicit times seem to be an important predictor of drusen regression.

Aged↗

PubMed2006

Spatial dependence of color assimilation by the watercolor effect.

Color assimilation with bichromatic contours was quantified for spatial extents ranging from von Bezold-type color assimilation to the watercolor effect. The magnitude and direction of assimilative hue change was measured as a function of the width of a rectangular stimulus. Assimilation was quantified by hue cancellation. Large hue shifts were required to null the color of stimuli < or = 9.3 min of arc in width, with an exponential decrease for stimuli increasing up to 7.4 deg. When stimuli were viewed through an achromatizing lens, the magnitude of the assimilation effect was reduced for narrow stimuli, but not for wide ones. These results demonstrate that chromatic aberration may account, in part, for color assimilation over small, but not large, surface areas.

Color Perception↗

PubMed2005

The watercolor effect: quantitative evidence for luminance-dependent mechanisms of long-range color assimilation.

When a dark chromatic contour delineating a figure is flanked on the inside by a brighter chromatic contour, the brighter color will spread into the entire enclosed area. This is known as the watercolor effect (WCE). Here we quantified the effect of color spreading using both color-matching and hue-cancellation tasks. Over a wide range of stimulus chromaticities, there was a reliable shift in color appearance that closely followed the direction of the inducing contour. When the contours were equated in luminance, the WCE was still present, but weak. The magnitude of the color spreading increased with increases in luminance contrast between the two contours. Additionally, as the luminance contrast between the contours increased, the chromaticity of the induced color more closely resembled that of the inside contour. The results support the hypothesis that the WCE is mediated by luminance-dependent mechanisms of long-range color assimilation.

Adult↗

PubMed2005

Senescence of spatial chromatic contrast sensitivity. I. Detection under conditions controlling for optical factors.

Chromatic contrast thresholds for spatially varying patterns of various spatial frequencies (0.5, 1, 2, and 4 cycles per degree) were measured for ten older (65-77 yr of age) and ten younger (18-30 yr of age) observers. The stimuli were Gabor patches modulated along S-varying or (L - M)-varying chromatic axes. Thresholds were determined for two sets of stimuli. For one set of stimuli, the mean chromaticity and luminance were equated at the cornea for all observers. The second set of stimuli was corrected for ocular media density differences to equate stimulation of each of the three cone types at the retina for each individual. Chromatic contrast thresholds were higher for older observers for all stimuli tested. The magnitude of this difference showed little dependence on spatial frequency. When stimuli were equated at the cornea, this difference was greater for S-varying stimuli. When stimuli were equated at the retina, the age-related difference in thresholds for S-varying stimuli was reduced. Both optical and neural factors contribute to these age-related losses in spatial chromatic contrast sensitivity.

Adolescent↗

PubMed2005

Senescence of spatial chromatic contrast sensitivity. II. Matching under natural viewing conditions.

Age-related changes in the spatial chromatic contrast sensitivity function of detection, measured along S and L - M cone axes, were demonstrated in a companion paper [Hardy et al., J. Opt. Soc. Am. A 22, 49 (2005)]. Here senescent changes in chromatic contrast appearance were assessed by contrast-matching functions (CMFs). Luminance and chromatic CMFs (S and L - M axes) were compared for younger (age 18-31 yr) and older (age 65-75 yr) trichromatic subjects by using stimuli that were perceptually anchored to the same physical standard contrasts. Subjects matched the contrast of test gratings of various spatial frequencies (0.5-8 cycles per degree) to the standard stimuli under natural viewing conditions. Because of changes in the visual system with age, the standard stimuli were closer to threshold for older subjects; however, in general, the shapes of the CMFs were similar for both groups. The results suggest that the perception of relative contrasts across spatial frequencies is stable with age.

Adolescent↗

PubMed2004

Color constancy under changes in reflected illumination.

Distinct physical processes can change the spectrum of the illumination that impinges on a surface. Here we consider two such changes. The first is a change in the spectrum of the light source that provides the scene illumination (light source change). The second is a change in the reflectance of a surface located near a test surface of interest (reflected light change). A color constant visual system must compensate for changes caused by both of these physical processes. We report measurements of constancy with respect to reflected light changes and compare them to results from a recent experiment that examines constancy across light source changes. Observers viewed synthetic images rendered from three-dimensional scene descriptions and displayed on a CRT-based stereoscope. They made achromatic adjustments to test surfaces embedded in the images. The degree of constancy varied with the color direction of the illuminant change, and the variation was similar for reflected light and light source changes. The overall level of constancy was lower for reflected light changes than for light source changes. A second experiment suggests that for our conditions, constancy across reflected light changes is driven almost entirely by changes in the local surround of the test. In a third experiment, observers made asymmetric matches across both types of illuminant change. Here the matches were essentially identical across both types of illuminant change.

Color↗

PubMed2004

Does human color constancy incorporate the statistical regularity of natural daylight?

The chromaticities of natural daylights cluster around the blackbody locus. We investigated whether the mechanisms that mediate human color constancy embody this statistical regularity of the natural environment, so that constancy is best when the illuminant change is one likely to occur. Observers viewed scenes displayed on a CRT-based stereoscope and adjusted a test patch embedded in the scene until it appeared achromatic. Scenes were rendered using physics-based graphics software (RADIANCE) coupled with custom extensions that ensured colorimetric accuracy. Across conditions, both the simulated illuminant and the simulated reflectance of scene objects were varied. Achromatic settings from paired conditions were used to compute a constancy index (CI) that characterizes the stability of object appearance across the two illuminants of the pair. Constancy indices were measured for four illuminant changes from a Neutral illuminant (CIE D65). Two of these changes (Blue and Yellow) were consistent with the statistics of daylight, whereas two (Green and Red) were not. The results indicate that constancy was least across the Red change, as one would expect for the statistics of natural daylight. Constancy for the Green direction, however, exceeded that for the Yellow illuminant change and was comparable to that for the Blue. This result is difficult to reconcile with the hypothesis that mechanisms of human constancy incorporate the statistics of daylights. Some possible reasons for the discrepancy are discussed.

Adult↗

PubMed2003

Assessment of multifocal electroretinogram abnormalities and their relation to morphologic characteristics in patients with large drusen.

OBJECTIVES: To determine the extent of functional changes in the first-order kernel multifocal electroretinogram (mfERG) responses in patients with large drusen by means of a localized analysis and to determine correlations between mfERG responses and morphologic changes. METHODS: Thirty-one eyes from 20 patients ages 58 to 84 years with large drusen (> or =5 drusen > or =63 microm diameter) were studied. The mfERGs were recorded with a stimulus of 103 hexagons and a flash intensity of 2.67 candela (cd).s-1.m-2. Each of the 103 single first-order kernel mfERG responses was analyzed and compared with those of age-matched healthy control subjects. Imaging studies, including color stereo fundus photography, red-free fundus photography, and fluorescein angiography, were performed in all patients, and morphologic changes (drusen in red-free fundus photography, staining or window defect in fluorescein angiography) were determined with a digital measurement tool. The mfERG responses were correlated to areas with and without morphologic changes. RESULTS: Reduced responses were found in 10.0% (scalar products) and 4.0% (response densities) and delayed implicit times in 13.8% (N1), 18.9% (P1), and 23.8% (N2) of all mfERGs. Abnormal mfERG responses extended up to 25 degrees in radius. Significant morphologic-functional relations were detected in only a few patients. Abnormal mfERG variables were present in areas without morphologic changes. CONCLUSIONS: Patients with large drusen exhibit functional changes in the cone-driven pathways evaluated by the mfERG, indexed particularly by implicit times. Morphologically visible changes do not predict retinal function. Large drusen are associated with a more general retinal dysfunction.

Aged↗

PubMed2003

Topography of the chromatic pattern-onset VEP.

The chromatic pattern-onset VEP has been used successfully as a sensitive and objective technique to determine congenital and acquired color vision deficiency. It also has been applied to characterize development, maturation and aging of the chromatic visual pathways. Here we determine the topographic components of the full-field VEP using the multifocal technique. Recordings were made with the VERIS system that extracts topographic VEPs using a pseudorandom stimulus sequence. Chromatic pattern stimuli were presented in an onset-offset temporal sequence, with colors modulated along different axes in the MBDKL color space. Additional experiments were conducted to verify the S-cone axis for each observer and that our chromatic stimuli were close to isoluminant at different field locations. Our data show reliable and robust chromatic onset VEP responses for multiple retinal areas that conform to pattern-onset full-field VEP waveform characteristics. For stimuli with chromatic contributions, pattern-onsets produced reliable and consistent waveforms whereas for stimuli with large luminance contributions pattern-reversal stimuli were superior. Our method for recording chromatic multifocal pattern-onset VEPs holds promise for clinical application to detect and monitor early retinal and optic nerve changes related to aging and disease.

Adult↗

PubMedDate not supplied

Long-term renormalization of chromatic mechanisms following cataract surgery.

The optical density of the human crystalline lens progressively increases with age, the greatest increase in the visible spectrum being at short wavelengths. This produces a gradual shift in the spectral distribution of the light reaching the retina, yet color appearance remains relatively stable across the life span, implying that the visual system adapts to compensate for changes in spectral sensitivity. We explored properties of this adaptive renormalization by measuring changes in color appearance following cataract surgery. When the lens is removed, cataract patients often report a large perceptual shift in color appearance that can last for months. This change in color appearance was quantified for four cataract patients (63-84 years) by determining the chromaticity of stimuli that appeared achromatic before surgery, and at various intervals after surgery for up to 1 year. Stimuli were presented on a calibrated CRT as 9.5-deg spots, with 3-s duration and 3-s interstimulus intervals (ISIs). Chromaticity was adjusted by the subjects in CIE L*a*b* color space with luminance fixed at 32 cd/m2, on a dark background. We also estimated the optical density of the cataractous lens by comparing absolute scotopic thresholds from 410 nm to 600 nm before and after surgery. The results demonstrated that immediately following surgery there is a large increase in the short-wave light reaching the retina, mainly below 500 nm. The achromatic settings generally showed an initial large shift in the "yellow" direction after surgery that gradually (but never fully) returned to the original achromatic point before surgery. The shifts in the achromatic point occur over a number of months and appear to occur independently of the fellow eye.

Adaptation, Ocular↗