Peter Batchelor | PubMed Health

PubMed2006

Posttraumatic spinal cord herniation.

We report a 28-year-old woman who presented with a partial Brown-Sequard syndrome 18 months after a fall from a horse. Investigation revealed the cause of her symptoms to be a spinal cord herniation at the level of T6. A review of previously reported cases of posttraumatic spinal cord herniation was undertaken. Six of the cases reported have clear evidence of injury at the site of subsequent herniation; the remaining five cases may be related to trauma or may be spontaneous spinal cord herniation, with an unrelated history of trauma.

Adult↗

PubMed2005

Dopaminergic innervation of the human striatum in Parkinson's disease.

In Parkinson's disease (PD), dopaminergic input to the caudate nucleus and a band of putaminal tissue abutting the external globus pallidus seems well preserved on immunohistochemical staining for the dopamine transporter. Counting of dopaminergic terminals showed that terminal density in these regions in PD was the same as that in controls, which indicates that input is truly preserved and not a consequence of a compensatory upregulation of metabolism in a reduced pool of surviving terminals. When the branching pattern of dopaminergic axons coursing through the globus pallidus was examined, we found no evidence for increased axonal sprouting in PD that might have contributed to preservation of dopaminergic input to the putamen or caudate nucleus. Although terminal counting indicated that anatomic input was preserved to parts of the striatum, dopamine uptake site density in these regions was reduced significantly. This suggests that the impact of disease in these areas is more profound than was thought previously.

Aged↗