Biomedical subjects
Publications and source records attributed to Peter Stingl.
At present there is a steady rise in African sleeping sickness (trypanosomiasis) transmitted by the Tsetse fly, and which if left untreated, is fatal. Thanks to more than so years of neglect by research, our therapeutic repertoire is limited to medications with a high level of toxicity. Both WHO and international aid organizations are pushing hard for the development of new, more efficient drugs that can be readily applied in the field.
Onchocerciasis, which is caused by filarial nematodes, affects roughly 18 million people in tropical Africa and is a major cause of morbidity, with a serious sociomedical impact. Although the present onchocerciasis control strategy comprising antifilarial chemotherapy and vector control is successful, it is associated with logistic problems due to the prolonged treatment duration. Furthermore, fears of drug resistance are on the increase. New approaches involving the use of antibiotics aimed at endobacteria living in symbiosis with filariae appear promising. Recent trials with tetracycline indicate a significant impact on worm viability.
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