PubMed Health⌕ Search

Biomedical subjects

Phil Barker

Publications and source records attributed to Phil Barker.

13 recordsLinked to original sources

ApTrkl, a Trk-like receptor, mediates serotonin- dependent ERK activation and long-term facilitation in Aplysia sensory neurons.

The Trk family of receptor tyrosine kinases plays a role in synaptic plasticity and in behavioral memory in mammals. Here, we report the discovery of a Trk-like receptor, ApTrkl, in Aplysia. We show that it is expressed in the sensory neurons, the locus for synaptic facilitation, which is a cellular model for memory formation. Serotonin, the facilitatory neurotransmitter, activates ApTrkl, which, in turn, leads to activation of ERK. Finally, inhibiting the activation of ApTrkl with the Trk inhibitor K252a or using dsRNA to inhibit ApTrkl blocks the serotonin-mediated activation of ERK in the cell body, as well as the cell-wide long-term facilitation induced by 5-HT application to the cell body. Thus, transactivation of the receptor tyrosine kinase ApTrkl by serotonin is an essential step in the biochemical events leading to long-term facilitation in Aplysia.

Amino Acid Sequence↗

The Tidal Model: psychiatric colonization, recovery and the paradigm shift in mental health care.

Psychiatric research and practice involves the colonization of the personal experience of problems of human living. From a Western perspective, this process shares many similarities with the subjugation of women, people of colour and people embracing non-Christian faiths and cultures. The Tidal Model is a mental health recovery and reclamation model, developed to provide the framework for discrete alternatives to the colonizing approach of mainstream psychiatric practice. The Model asserts the intrinsic value of personal experience and the centrality of narrative in the development of contextually bound, personally appropriate, mental health care. This paper summarizes the features of the Model, which attempt to address the foci of the more significant critiques of psychiatric practice (and psychiatric nursing), against a background sketch of psychiatric colonization.

Humans↗

The tidal model. The healing potential of metaphor within a patient's narrative.

1. The human experience of growth and development is a fluid phenomenon, occurring in small, barely visible changes. 2. The Tidal Model embraces a patient's expression of his or her experience by focusing on the lived experience of the narrative and its personally meaningful metaphors and symbols. 3. To re-empower a patient, the Tidal Model assessment is written in the patient's own voice and all care planning is conducted conjointly. 4. The Tidal Model was developed from empirical studies of the perceived need for nursing and the process of empowerment in clinical nursing practice.

Holistic Nursing↗

Experts without a voice.

Explore the source record for details and available documents.

Academies and Institutes↗

More than a feeling.

Explore the source record for details and available documents.

Altruism↗

Missing pieces.

Explore the source record for details and available documents.

Career Choice↗

Dear CNO.

Explore the source record for details and available documents.

Humans↗

Caring as a craft.

Explore the source record for details and available documents.

Empathy↗

Stay in touch.

Touch is used in many cultures as a means of relating directly with another person. In this seventh article in our Heart of Nursing series, we look at how touch, used judiciously, can be a priceless form of doing.

Communication↗