Retinal nerve fiber layer thickness in amblyopic eyes.
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Biomedical subjects
Publications and source records attributed to Philip Lempert.
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The relationship between cigarette smoking by young women and amblyopia in children was investigated in 13 population groups. Two searches were conducted on Medline using the following keywords for the first search: amblyopia, prevalence or incidence, and the names of specific countries. The keywords for the second search were smoking, cigarettes, women and the names of the same specific countries. Relevant articles were reviewed. A positive relationship between the rate of smoking among women and the prevalence of amblyopia in school-aged children and military recruits was found. The Pearson correlation coefficient was 0.73. The occurrence of decreased visual acuity attributed to amblyopia in disparate population groups is directly related to rates of cigarette smoking by young women.
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OBJECTIVE: Hyperopic anisometropia is a risk factor for amblyopia. Disc areas and axial lengths are reduced in amblyopic eyes. This study's aim was to investigate the differences in the relative size of the optic disc in 5 groups of eyes: (1) normal right eyes; (2) smaller eyes of nonamblyopic, anisometropic, bilateral hyperopes; (3) larger eyes of nonamblyopic, anisometropic, bilateral hyperopes; (4) fellow (nonamblyopic) eyes of eyes of amblyopic, anisometropic, bilateral hyperopes; and (5) amblyopic eyes of bilateral hyperopic anisometropes. To determine the relative size of the discs, the relationships of axial length to disc area in the above groups were evaluated. DESIGN: Case-control study. PARTICIPANTS: Nine hundred twenty-seven records from the author's private practice, which included axial length measurements and optic disc photographs or digital images, were analyzed to form the 5 groups above. METHODS: Disc areas were measured using objective techniques developed by Bengtsson and Krakau. Axial lengths were determined by ultrasound biometry or with a Zeiss IOL Master. MAIN OUTCOME MEASURES: Optic disc areas, corrected for magnification, axial lengths, and a derived ratio, axial length/disc area (AXL/DA). RESULTS: The AXL/DA for the amblyopic eyes (group 5) was significantly greater than that of all of the other groups, indicating that amblyopic eyes have discs that are both absolutely smaller and, when adjusted for eyes' size, relatively smaller than those of nonamblyopic eyes. CONCLUSION: The relatively small size of the discs of amblyopic eyes points to an organic as opposed to a functional amblyopia in these patients.
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BACKGROUND: Hyperopia is a risk factor for esotropia and amblyopia. A previous study indicated that disc areas (DAs) are reduced in patients with amblyopia. OBJECTIVE: To determine if there is a difference in the relative size of the optic disc in hyperopic eyes without strabismus or amblyopia compared with esotropic and amblyopic eyes, the relationship of axial length (AXL) to DA in subjects with hyperopia was evaluated. METHODS: Eight hundred fifty records from my private practice, which included AXL measurements and optic disc photographs or digital images, were analyzed to locate 122 subjects with bilateral refractive errors greater than +2.00 diopters. Disc areas were measured using objective techniques. Axial lengths were determined by ultrasonographic biometry. A ratio, AXL/DA, was derived by dividing the AXL in millimeters by the DA in square millimeters. RESULTS: The mean (SD) AXL/DA for the group with hyperopia was 9.48 (2.70) mm and 12.30 (3.45) mm for the group with hyperopic strabismus (P =.01). The mean (SD) AXL/DA was 15.24 (4.61) mm in the amblyopic eyes and 13.61 (3.67) mm for the nonamblyopic fellow eye (P =.02). CONCLUSION: The optic discs of eyes with hyperopic strabismus with and without amblyopia were disproportionately and markedly reduced when compared with hyperopic eyes without amblyopia or esotropia.
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