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Biomedical subjects

Philip V Scribano

Publications and source records attributed to Philip V Scribano.

6 recordsLinked to original sources
PubMed2004

Difficulty in obtaining peak expiratory flow measurements in children with acute asthma.

OBJECTIVE: To determine the frequency with which children >or=6 years with acute asthma can perform peak expiratory flow rate measurements (PEFR) in an emergency department (ED). DESIGN/METHODS: Data were obtained from a prospective cohort study of children with acute asthma. All children (age 2-18 years old) treated in an urban pediatric ED for an acute exacerbation during randomly selected days over a 12-month period were prospectively evaluated. According to treatment protocols, PEFR was to be measured in all children age 6 years and older before therapy and after each treatment with inhaled bronchodilators. Registered respiratory therapists obtained PEFR and evaluated whether patients were able to perform the maneuver adequately. RESULTS: Four hundred and fifty-six children, 6 to 18 years old (median 10 years), were enrolled; 291 (64%) had PEFR measured at least once. Of those in whom PEFR was attempted at least once, only 190 (65%) were able to perform adequately. At the start of therapy, 54% (142/262) were able to perform PEFR. Of the 120 who were unable to perform initially, 76 had another attempt at the end of the ED treatment, and 55 (72%) were still unable to perform. A total of 149 patients had attempts at PEFR both at the start and end of treatment, of these, only 71 (48%) provided valid information on both attempts. Patients unable to perform PEFR were younger (mean +/- SD = 8.7 +/- 2.8 years) than those who were able to perform successfully (11.2 +/- 3.2 years) and those with no attempts (10.0 +/- 3.4 years). Children admitted to the hospital were more likely to be unable to perform PEFR (58/126 = 46%) than those discharged from the ED (43/330 = 13%, P < 0.0001). CONCLUSION: Adequate PEFR measurements are difficult to obtain in children with acute asthma. Treatment and research protocols cannot rely exclusively on PEFR for evaluation of severity.

Acute Disease↗
PubMed2004

An intentional opiate intoxication of an infant: when medical toxicology and child maltreatment services merge.

We present an instructive case of a 5-week-old infant seen in the emergency department with acute inspiratory stridor and depressed level of consciousness. His emergency department course identified an acute opiate intoxication. The child also developed chest wall rigidity, a rare complication of narcotic use. We discuss the emergency department management, as well as the toxicologic and child protection investigations.

Analgesics, Opioid↗
PubMed2004

Performance of a novel clinical score, the Pediatric Asthma Severity Score (PASS), in the evaluation of acute asthma.

OBJECTIVES: To evaluate the reliability, validity, and responsiveness of a new clinical asthma score, the Pediatric Asthma Severity Score (PASS), in children aged 1 through 18 years in an acute clinical setting. METHODS: This was a prospective cohort study of children treated for acute asthma at two urban pediatric emergency departments (EDs). A total of 852 patients were enrolled at one site and 369 at the second site. Clinical findings were assessed at the start of the ED visit, after one hour of treatment, and at the time of disposition. Peak expiratory flow rate (PEFR) (for patients aged 6 years and older) and pulse oximetry were also measured. RESULTS: Composite scores including three, four, or five clinical findings were evaluated, and the three-item score (wheezing, prolonged expiration, and work of breathing) was selected as the PASS. Interobserver reliability for the PASS was good to excellent (kappa = 0.72 to 0.83). There was a significant correlation between PASS and PEFR (r = 0.27 to 0.37) and pulse oximetry (r = 0.29 to 0.41) at various time points. The PASS was able to discriminate between those patients who did and did not require hospitalization, with area under the receiver operating characteristic curve of 0.82. Finally, the PASS was shown to be responsive, with a 48% relative increase in score from start to end of treatment and an overall effect size of 0.62, indicating a moderate to large effect. CONCLUSIONS: This clinical score, the PASS, based on three clinical findings, is a reliable and valid measure of asthma severity in children and shows both discriminative and responsive properties. The PASS may be a useful tool to assess acute asthma severity for clinical and research purposes.

Adolescent↗
PubMed2003

Construct validity and responsiveness of the Child Health Questionnaire in children with acute asthma.

OBJECTIVE: To examine the validity and responsiveness of the Child Health Questionnaire (CHQ-PF28) in the context of acute exacerbation of asthma in children. DESIGN AND METHODS: This was a prospective cohort study of children age 5 years and older treated for acute asthma at two urban pediatric emergency departments (EDs). At 14 days after the visit, all patients were contacted by telephone and the CHQ-PF28 (modified to have a 2-week recall period) was administered. Poor 14-day outcome was defined as one or more of the following: child or parent missed at least 5 days of school/day care/work; child still having asthma symptoms above baseline at 14 days; or unscheduled care within 7 days after the ED visit. RESULTS: A total of 732 subjects (median age, 9 years) were enrolled; 622 (85%) had successful follow-up at day 14. At the 14-day follow-up, 254 (43%) were classified as having a poor outcome. The mean physical subscale score of the CHQ-PF28 was 48.2 among those with a good outcome, vs 35.9 among the poor outcome group (difference = 12.3; 95% confidence interval, 10.2 to 14.3). For the psychosocial subscale the average difference between groups was 6.9 (95% confidence interval, 5.1 to 8.7). Among the 146 patients at one site who also had a CHQ score obtained at the initial visit, there was a significant improvement in mean physical subscale score among those with good, but not poor, outcome. However, the relative responsiveness was moderate, with an effect size of only 0.37. CONCLUSIONS: Both the physical and psychosocial subscales of the CHQ-PF28 administered 14 days after an ED visit for acute exacerbation of asthma are correlated with poor short-term functional outcome, but scores are only moderately responsive to acute changes in functional status.

Acute Disease↗