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Biomedical subjects

Philippe Bado

Publications and source records attributed to Philippe Bado.

3 recordsLinked to original sources

Fabrication and characterization of microstructures with optical quality surfaces in fused silica glass using femtosecond laser pulses and chemical etching.

We present a study of the sidewall surface quality inside microchannels fabricated in fused silica glass by femtosecond laser pulses and chemical etching. Multiple combinations of laser exposure and etching solution parameters were examined. Results of scanning electron microscopy, atomic force microscopy, and optical reflection analyses of the surfaces are presented. The results obtained demonstrate the feasibility of optical quality surface fabrication, which in turn demonstrates the feasibility of fabricating complex integrated devices containing microfluidic channels and optical waveguides in the glass substrates.

Journal Article↗

Waveguide electro-optic modulator in fused silica fabricated by femtosecond laser direct writing and thermal poling.

An integrated electro-optic waveguide modulator is demonstrated in bulk fused silica. A Mach-Zehnder interferometer waveguide structure is fabricated by direct writing with a femtosecond laser followed by thermal poling. A 20 degrees electro-optic phase shift is achieved at an operating wavelength of 1.55 microm with an applied voltage of 400 V and an interaction length of 25.6 mm, which correspond to an estimated effective electro-optic coefficient of 0.17 pm/V for the TE-polarized mode.

Journal Article↗

Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping.

Effective methods for manipulating, isolating and sorting cells and particles are essential for the development of microfluidic-based life science research and diagnostic platforms. We demonstrate an integrated optical platform for cell and particle sorting in microfluidic structures. Fluorescent-dyed particles are excited using an integrated optical waveguide network within micro-channels. A diode-bar optical trapping scheme guides the particles across the waveguide/micro-channel structures and selectively sorts particles based upon their fluorescent signature. This integrated detection and separation approach streamlines microfluidic cell sorting and minimizes the optical and feedback complexity commonly associated with extant platforms.

Cell Culture Techniques↗