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Biomedical subjects

Philippe Camparo

Publications and source records attributed to Philippe Camparo.

8 recordsLinked to original sources
PubMed2006

Expression of epidermal growth factor receptor and proliferative activity of cyst epithelium in human renal cystic diseases.

Pathogenesis of malignancies in patients with polycystic kidney disease (PKD) is not clearly understood. Epidermal growth factor receptor (EGF-r) production by mature kidney plays a role in promotion of epithelial hyperplasia and cyst formation, its involvement in further progression is however not proven. Ki-67 is a marker for cellular proliferation. We assessed immunohistochemical expression of EGF-r and Ki-67 in epithelium of normal kidney, single cysts without PKD, epithelial tubular cells lining simple cysts and cysts with papillary proliferation in PKD patients, and analyzed the relationship with the occurrence of malignant tumors in these cases. 72% of PKD displayed EGF-r staining in epithelium lining cysts versus 33% in normal epithelium and 70% in epithelium of normal kidney. Ki-67 was increased in papillary cystic epithelium (24%) and in cysts lined by flat epithelium (66%). Renal cancers in PKD showed EGF-r staining in 33%, but no Ki-67 expression. EGF-r function and proliferative activity in cyst formation in PKD remains to be explored. EGF-r and Ki-67 expressions are not predictive of development of carcinoma in PKD.

Adult↗
PubMed2005

Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 cases.

P63 is a member of the p53 family, which plays a role in the differentiation of urothelium and is supposed to play a role in urothelial carcinogenesis. P53 and MIB-1 are recognised in many studies as predictive markers of progression, but few studies in the literature have examined p63. The aims of our study were to explore the expression of p63 in bladder carcinomas and to compare this expression to p53 and MIB-1, as well as to stage and grade. Tissue microarrays were performed on 158 urothelial carcinomas (56 pTa, 45 pT1 and 57>or=pT2). Immunohistochemical studies were performed with p63, p53 and MIB-1 antibodies. In our study we observed that p63 immunostaining is present in all cell layers in papillary urothelial neoplasm of low malignant potential (PUNLMP), but partially lost in non-invasive papillary urothelial carcinoma low grade (NILGC) and in pT1/>or=pT2 bladder cancers. P53 and MIB-1 displayed lower expression in PUNLMP/NILGC vs non-invasive papillary urothelial carcinoma high grade (NIHGC)/pT1, but there was no correlation between the expression of p63, p53 and MIB-1. Our study demonstrates that p63 expression distinguishes between PUNLMP/NILGC and NIHGC/pT1 (p=4.10(5)). A statistical difference disserving pTa and pT1/>or=pT2 with a statistical significance (p<10(-6)) could also be observed. P63 should be considered as an additional biomarker that might help pathologists to classify their patients.

Adult↗
PubMed2005

[Tumors of the kidneys: new entities].

Since 1998 new entities have surfaced in renal tumor classification and have been included in the WHO 2004 classification. In this article, we will discuss the following entities: multilocular clear cell renal carcinoma, Xp11 translocation carcinoma, low grade mucinous tubular carcinoma, epithelioid angiomyolipoma, benign mixed epithelial and stromal tumor. We will investigate new concepts of hybrid oncocytoma and chromophobe renal cell carcinoma and the syndrome of Birt-Hogg-Dube which is associated to kidney tumors. At least, we will touch on new elements in the Bellini carcinoma definition.

Adenocarcinoma, Clear Cell↗
PubMed2005

Primitive neuroectodermal tumor of the stomach.

Ewing sarcoma/primitive neuroectodermal tumor is classically a tumor of the soft tissue or bone in children and young adults, but several cases have been described in patients of all ages. Within the last decade, the clinicopathologic spectrum of Ewing sarcoma/primitive neuroectodermal tumor has been markedly expanded by recognition that the tumor may also have a visceral origin. We describe a case of primitive neuroectodermal tumor arising in the stomach of a 66-year-old woman. The neoplasm was excised using a radical surgical procedure. Microscopically, the tumor was made up of solid nests and sheets of round cells. Immunohistochemically, the tumor cells showed immunoreactivity for CD99, S100, neuron-specific enolase, and vimentin. A multiplex real-time polymerase chain reaction assay detected an EWS-ERG fusion. To our knowledge, this is the first description of a primitive neuroectodermal tumor arising in the stomach.

Aged↗
PubMed2004

[Common variable immunodeficiency and celiac disease].

Variable immunodeficiency is frequently associated with subtotal villous atrophy, unchanged by gluten free diet. We report two cases of common variable immunodeficiency associated with chronic symptoms of malabsorption due to total villous atrophy. Symptoms of malabsorption disappeared and histological abnormalities improved after a gluten free diet. The association between celiac disease and common variable immunodeficiency should not be considered as fortuitous. Clinicians should be aware of this association and of the low sensitivity of serologic testing in this setting.

Celiac Disease↗
PubMed2003

[Solitary fibrous tumor of the kidney].

The diagnosis of solitary fibrous tumour, usually a benign lesion, is rarely suggested in a case of renal mass due to the rarity of these lesions. The authors report a case of a very large hilar mass in a 35-year-old man. Histological examination was performed on the operative specimen, as preliminary CT-guided needle biopsy was non-diagnostic. The diagnosis of primary spindle cell tumour was confirmed by immunohistochemical analysis. Independently of the size of this tumour and its intimate relations with the hilar region, large surgical resection should be performed due to the possible presence of malignant contingents and the risk of local recurrence or metastatic spread.

Adult↗
PubMed2002

[Testicular epidermoid cyst: limits of conservative surgery. Report of 16 cases].

OBJECTIVE: To define the clinical criteria and complementary investigation results allowing conservative surgery for epidermoid cysts of the testis. MATERIALS AND METHODS: 16 patients with epidermoid cyst were managed in our department. Assessment of each patient included clinical examination, tumour marker assay and imaging (scrotal ultrasound in 16 cases and MRI in 2 cases). All patients were operated via an inguinal incision with primary clamping of the cord. No patient was lost to follow-up. RESULTS: Tumourectomy was performed in 3 patients after frozen section histological examination confirmed the diagnosis of epidermoid cyst. No disease progression was observed with a mean follow-up of 57 months (range: 3 to 108 months). CONCLUSIONS: Conservative surgery for epidermoid cyst is possible on the basis of precise criteria: typical ultrasound (or MRI) image, size less than 2 centimetres, normal tumour marker assays, frozen section histological examination confirming the diagnosis.

Epidermal Cyst↗