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Biomedical subjects

Philippe Grise

Publications and source records attributed to Philippe Grise.

At least 19 recordsLinked to original sources
PubMed2007

Pediatric urinary incontinence: evaluation of bladder wall wraparound sling procedure.

PURPOSE: In 1996 a surgical procedure for sphincter deficiency was reported in patients with neurogenic urinary incontinence. To our knowledge we report the first series that assesses this procedure since it was initially described. MATERIALS AND METHODS: Seven female and 7 male patients with spinal dysraphism and neurogenic intrinsic sphincter deficiency underwent surgery between 1997 and 2005. All patients had an associated poorly compliant or small capacity bladder. Patient age ranged from 8 to 22 years (mean 14) and all patients presented with persistent urinary incontinence despite intermittent catheterization and pharmacotherapy. Evaluation was based on clinical examination, as well as preoperative and postoperative urodynamic assessments. The surgical procedure involved wrapping a pedicle strip of anterior bladder wall around the bladder neck and fixing it on the pubic symphysis. Bladder augmentation cystoplasty was also routinely performed during the same procedure. RESULTS: Of 14 patients 13 were completely dry and 1 had stress incontinence. Followup was 2 to 8 years (mean 5). Postoperative urodynamic evaluation showed a maximum urethral pressure increase of 40%. We also observed an increase in bladder capacity of 105% and improved bladder compliance (7 ml/cm H(2)O preoperatively vs 35 ml/cm H(2)O postoperatively). CONCLUSIONS: The bladder wall wraparound sling procedure provides excellent results for continence in association with bladder augmentation.

Adolescent↗
PubMed2006

Intravesical glucidic capsaicin versus glucidic solvent in neurogenic detrusor overactivity: a double blind controlled randomized study.

AIMS: Many studies report the use of alcoholic capsaicin instillation to treat neurogenic detrusor overactivity (NDO) in spinal cord injured (SCI) and multiple sclerosis (MS) patients. However, poor tolerability due to the irritative effect of the ethanol solvent limits its use. Our study aimed to evaluate the efficacy and tolerability of a new formulation of capsaicin in a glucidic solution in a multicenter clinical trial. MATERIALS AND METHODS: Thirty-three patients (26MS/7SCI) suffering from urinary incontinence due to refractory NDO were prospectively enrolled in a double-blind placebo controlled study and randomized to capsaicin group (CG, N = 17) or solvent group (SG, N = 16). They respectively received an intravesical instillation of 100 ml capsaicin diluted in glucidic solvent (CG) or glucidic solvent alone (SG). Efficacy (voiding chart, maximum cystometric capacity (MCC)) and tolerability were evaluated on days 0 (D0), 30 and 90. RESULTS: On D0, groups were homogeneous. On D30, significant improvement of overactive bladder syndrome and an increase in MCC were shown in CG, whereas there were no improvement in SG. No significant improvement was shown on D90 in both groups. There were no significant differences between groups regarding prevalence, duration, or intensity of side effects, except for short duration pubic pain during instillation more often reported in CG (58.8%) than in SG (12.5%) (P < 0.01). CONCLUSION: This placebo controlled study using glucidic capsaicin confirms its short-term efficacy in NDO patients. Global tolerance of glucidic capsaicin appeared satisfactory. Long-term efficacy and tolerance of repeated glucidic capsaicin instillations need to be evaluated.

Adult↗
PubMed2006

Transobturator tape sling for female stress incontinence with polypropylene tape and outside-in procedure: prospective study with 1 year of minimal follow-up and review of transobturator tape sling.

OBJECTIVES: To assess the efficacy and safety of a minimally invasive surgical procedure using a polypropylene transobturator tape to treat female stress urinary incontinence during a minimal follow-up of 1 year and to present a review of this technique. METHODS: A total of 206 women with stress urinary incontinence who underwent the transobturator tape procedure in a French multicenter prospective open tracker study, with a minimal follow-up of 1 year (range 12 to 33 months), were assessed. A nonelastic, polypropylene tape was placed under the mid-urethra. The surgical placement technique used a vaginal and transobturator percutaneous approach. Postoperative assessments included clinical examination, cough-stress test (full bladder), uroflowmetry, and postvoid residual urine volume performed after 1, 6, 12, 18, and 24 months. RESULTS: The mean follow-up was 16 months (range 12 to 33). Of the 206 patients, 79.1% were completely cured, 13% improved, and 7% failed. No vascular, nervous system, or digestive perioperative complications were observed; however, 2.4% of the patients had postoperative urinary retention. CONCLUSIONS: The results of the present study have confirmed the optimal results in stress incontinence previously reported in short-term studies. These results suggest that the transobturator tape procedure is a valuable alternative to the transvaginal tape procedure, with a low rate of complications.

Adult↗
PubMed2006

What is the optimum dose of type A botulinum toxin for treating neurogenic bladder overactivity?

OBJECTIVE: To assess the effects of two doses of botulinum toxin A (Dysport, Ipsen-Biotech, France; 500 and 1000 Speywood units, SU) injected into the bladder for treating incontinence due to a neurogenic overactive bladder. PATIENTS AND METHODS: In an open-label, prospective study between October 2002 and May 2004, in two centres, we analysed the effects of successive doses of 500 and 1000 SU of Dysport, endoscopically injected into the detrusor muscle. At each step, patients (26 women and 19 men) were re-evaluated at 1 month (clinical evaluation and pressure-flow study). If there was a 'good' clinical response (complete absence of urinary leakage) the patient was observed until incontinence recurred; otherwise a further injection was administered at a higher dose. RESULTS: The mean (sd, range) follow-up was 22 (0.75, 5-31) months; 11 of the 45 patients (24%) did not respond primarily at 1 month for both doses. The analysis of the two curves of survival with no re-injection of Dysport showed a statistically longer action at 1000 SU (P = 0.016). However, in this group there was one patient with general muscle weakness and asthenia, which could have been related to the injection. CONCLUSIONS: The optimum dose of Dysport for incontinence secondary to a neurogenic overactive bladder is not yet defined; 1000 SU probably has a more prolonged effect than 500 SU but exposes the patient to major complications. Further studies evaluating the clinical effect of 750 SU of Dysport are necessary.

Botulinum Toxins, Type A↗
PubMed2006

[Randomized study comparing piroxicam analgesia and tramadol analgesia during outpatient electromagnetic extracorporeal lithotripsy].

OBJECTIVE: To analyse the efficacy of two types of analgesia protocols during outpatient electromagnetic extracorporeal lithotripsy (ESWL) with a STORZ Modulith SLX second generation lithotriptor. MATERIAL AND METHODS: One hundred and seventy one patients were prospectively randomized to 2 groups. Group 1 (n-82) received 40 mg of Piroxicam IM, and group 2 (n=89) received 100 mg Tramadol IV Lithotripsy was performed in 2 sequences, T1 and T2, during which quantitative evaluation of pain (VE) was performed according to a VAS scale and qualitative evaluation of pain (QE) was performed according to the McGill questionnaire. Endpoints included the mean VE and QE pain scores at T1 and T2, the maximum power tolerated at T2, the postoperative pain at the 6th, 12th and 24th hours after ESWL, the pain score according to the power and according to the frequency and adverse effects. Comparisons were performed by analyses of variance (significant for p < 0.05). RESULTS: No significant difference was observed between the two groups for stone dimensions, duration and number of ESWL shots (p > 0.05) and significant difference was observedfor pain with the two drugs used. Pain was more severe as frequency and power increased. Only one intervention was stopped because of pain. Data analysis suggests that tramadol induces more adverse effects. CONCLUSION: Piroxicam and tramadol are two analgesics commonly used in clinical practice and both are suitable for the treatment of pain during outpatient extracorporeal lithotripsy.

Ambulatory Care↗
PubMed2005

[Pyeloplasty: aesthetic benefit of lumboscopy].

STUDY OBJECTIVE: To evaluate the aesthetic benefit of lumboscopy versus lumbotomy in a group of patients undergoing pyeloplasty. MATERIAL AND METHOD: A telephone survey was conducted in 103 people operated by pyeloplasty via lumboscopy or lumbotomy. The questions concerned the appearance of the scar (size, relief; visible or invisible), skin complications, satisfaction with the scar, postoperative pain, length of hospital stay and return to physical activity or work. RESULTS: The response rate was 58.2% corresponding to 32 lumboscopies and 29 lumbotomies. Lumboscopy scars were shorter (2.7 vs 15.6 cm for lumbotomies, p<0.001). Lumbotomy scars were palpable in 75% of cases versus 53.1% of lumboscopy scars of (p=0.037). Almost 96.5% of lumbotomy scars were visible versus only 68.7% of lumboscopy scars (p=0.0057). Lumbotomies were complicated by incisional hernia in 14.2% of cases, while no incisional hernias were observed in the lumboscopy group (p=0.02). 85% of patients were satisfied with their scars in the lumboscopy group versus 56% of patients operated by lumbotomy (p=0.0286). CONCLUSION: This study showed a statistically significant difference in terms of a purely aesthetic benefit and scar solidity in favour of lumboscopy, which supports the growing place of this surgical technique in urology.

Adolescent↗
PubMed2005

[Multilocular cystic nephroma in an adult: diagnostic and therapeutic strategy].

The authors report two clinical cases of cystic nephroma in adults observed in the department over the last 10 years. The nonspecific clinical findings and the poor contribution of imaging examinations make this rare disease difficult to diagnose. Only histological examination can confirm the diagnosis and eliminate multilocular cystic renal carcinoma or necrotic pseudocystic carcinoma. Based on a review of the literature, the authors emphasize recent pathophysiological and immunohistochemical data that could improve the management of this benign disease, in which malignant transformation is also possible.

Female↗
PubMed2005

[Transvaginal treatment of anterior vaginal prolapse with collagen implant transobturator fixation].

INTRODUCTION: Prolapse is a common disease with a multifactorial aetiology that may be either isolated or associated with other pelviperineal defects. Surgical reconstruction of the infravesical anterior segment by isolated colpomyorraphy of prolapse is often disappointing with a recurrence rate of 40% according to the literature. Several procedures, consisting of strengthening of the anterior vaginal wall have been proposed. The use of prosthetic material has revolutionized the treatment of cystocele with a reduction of the recurrence rate but at the price of a poorly defined morbidity. Few published studies have assessed the use of xenogeneic tissue in the treatment of anterior vaginal prolapse. The objective of this study was to demonstrate the feasibility, morbidity and short-term results of the use of Pelvicol reticulated collagen mesh in the treatment of cystoceles. OBJECTIVE: To demonstrate the feasibility and short-term results of the transvaginal treatment of cystoceles using collagen implant transobturator (TO) fixation. Many new prosthesis-based techniques are designed to decrease recurrences after repair without prosthesis, but they are often non-standardized, with inadequate evaluation and insufficient follow-up. In contrast with synthetic material, few published studies have investigated the use of xenogeneic tissue. PATIENTS AND METHODS: Twenty-eight patients with a mean age of 70.6 years (range: 53-84) with grade 2 and 3 cystocele and a history of transvaginal prolapse repair in 7 cases, were operated by 2 operators according to an identical technique: the bladder was dissected via a transvaginal approach and a 4 x 7 cm porcine dermis collagen prosthesis was then placed underneath the bladder and fixed, at its anterolateral angles via a TO approach to the midline suburethral part by a resorbable suture. Vaginal hysterectomy was associated in 11 cases. RESULTS: The mean specific prosthesis insertion time was 25 minutes. No intraoperative complication and no serious bleeding were reported. The mean hospital stay was 3.6 days (range: 2-9). The mean follow-up was 8 months (range: 6-16). One case of mesh expulsion was observed on D15, followed by complete healing without recurrence of the cystocele. One case of slight pain of the medial aspect of the thigh was observed with a favourable secondary outcome. The postoperative anatomical results showed complete repair of the prolapse at 1 month and on review. Two cases of de novo SUI were treated by transobturator suburethral tape with a good postoperative result. CONCLUSION: The technique is feasible, simple, safe and ensures very satisfactory short-term results. Follow-up of these patients will be continued.

Aged↗
PubMed2005

[Lomboscopic surgery for renin-secreting tumour].

Renin-secreting tumour is a rare, benign entity, responsible for hypertension due to secondary hyperaldosteronism. It must be treated surgically. In the light of a review of the literature, the authors report the first published case of resection of a juxtaglomerular tumour of the kidney by laparoscopic partial nephrectomy using an ultrasound scalpel.

Adult↗
PubMed2004

[Fibro-urothelial polyp in a horseshoe kidney in the case of Turner syndrome].

The authors report a case of fibro-epithelial polyp in a young woman with Turner syndrome with features of a right ureteropelvic junction syndrome in a horseshoe kidney. The patient presented a history of chronic low back pain associated with macroscopic haematuria leading to various complementary investigations including ureteroscopy. The endoscopic appearance of the tumour suggested the diagnosis despite the presence of atypical renal pelvis cytology. Pyeloplasty and proximal ureterectomy allowed confirmation and treatment of this rare lesion.

Adult↗
PubMed2004

[Can transobturator tape for urinary incontinence cause complete urinary retention?].

The surgical management of stress urinary incontinence has been revolutionized with the development of minimally invasive suburethral tape techniques, which ensure a high continence rate by means of a rapid procedure with a short hospital stay. Although morbidity and adverse effects are uncommon, they must be kept in mind in order to adopt an appropriate strategy designed to prevent their development. Urinary retention is the most frequent postoperative complication of retropubic tape. The recent transobturator tape technique modifies the location of the tape with an angulation more close resembling that of fascial support tissues, thereby decreasing the theoretical risk of retention. The authors report the first case of complete urinary retention and discuss the mechanism and therapeutic strategy.

Aged↗
PubMed2003

[Complications of TVT].

Surgical repair of stress urinary incontinence by TVT was first performed in France in 1998, without any real evaluation of the morbidity related to this product before its release onto the market. In the context of the Necker 2002 report, a review of the literature and a multicentre study were performed to clarify this point. Bladder perforation, frequent during the early part of the learning curve, requires repositioning of the TVT and bladder catheterization for 48 hours, but does not cause any increase in postoperative morbidity. Urethral perforation, much less common, is a contraindication to maintenance of the TVT. Postoperative obstruction occurs in 5% to 12% of cases, and initially requires self-catheterization, as early section of TVT must be avoided. De novo instability is observed in 6% to 12% of cases, especially in the case of incomplete obstruction or a gaping bladder neck. Erosions due to TVT appear to be uncommon and are essentially vaginal.

Humans↗
PubMed2003

[Impact of rectal prolapse and rectocele on TVT results].

OBJECTIVES: The comorbidity between rectal repair surgery and stress urinary incontinence (SUI) repair by TVT (simplified suburethral sling procedure) is a poorly defined entity. The objective of this study was to evaluate the influence of this combination on the quality of postoperative voiding and urinary continence. METHODS: Retrospective analysis of 12 patients (group 1) simultaneously treated by TVT and rectocele repair by anterior rectal mucosectomy (Sullivan: 6 cases) or rectal prolapse repair (open rectal fixation: 6 cases). They were compared to a group of 12 randomly selected patients (group 2) treated by TVT alone during the same period. RESULTS: A significant post-voiding residual urine volume was observed in 4 women of group 1 versus only one woman of group 2. All patients subsequently and spontaneously resumed satisfactory voiding except for one woman of group 1, in whom self-catheterization had to be maintained. After a mean follow-up of 18 months for group 1 and 17 months for group 2, only one woman, in group 2, was still incontinent. CONCLUSION: Rectal repair surgery, combined with TVT, increases the risk of transient postoperative urinary retention. This surgical combination does not appear to modify the medium-term result of the urological procedure.

Female↗
PubMed2003

[Bladder leiomyoma. Diagnostic and therapeutic approach].

The authors report their experience of four cases of bladder leiomyoma. Although MRI is currently the reference radiological examination, the diagnosis must be confirmed by histological examination. The various diagnostic steps and resulting therapeutic indications are described with a review of the literature.

Algorithms↗
PubMed2003

[Study of the prognostic value of DNA ploidy and proliferation index (Ki-67) in renal cell carcinoma with venous thrombus].

INTRODUCTION: Malignant tumours of the renal parenchyma are accompanied by extension to the inferior vena cava in 4% to 10% of cases. The objective of this study was to compare DNA ploidy and proliferation index of renal cell carcinoma (RCC) with renal vein (RV) thrombus and RCC with inferior vena cava (IVC) thrombus and to investigate a correlation between these markers and Fuhrman grade and patient survival. MATERIAL AND METHODS: A retrospective study was conducted in 58 patients with RCC and venous thrombus (40 in the RV and 18 in the IVC). Flow cytometry (FCM) and MiBI antibody immunolabelling (Ki-67 index) were performed on the healthy parenchyma, the renal tumour and the venous thrombus. Eighteen tumours with inferior vena cava thrombus were compared to 40 tumours with renal vein thrombus. Fuhrman grade, the presence of capsular rupture, invasion of the perirenal fat, and the presence of sarcomatoid transformation were investigated for a possible correlation with survival. RESULTS: No difference of expression of Ki-67 antigen expression was observed between the two populations of renal tumours with thrombus (RV/IVC), but a significant difference was observed for the two types of thrombus (RV/IVC). A difference in ploidy index was observed was also observed between tumours with RV and IVC thrombus (p<0.005). The tumours had less intense MiB1 immunolabelling and a lower DNA ploidy than their corresponding renal vein and inferior vena cava thrombi (Ki-67: 1.07% vs 5.12%, p<0.01: DNA index: 1.61 vs 1.87, p<0.01). A correlation between Fuhrman grade and tumour DNA index was demonstrated (1.149 for low grade tumours and 1.857 for high grade tumours, p<0.05). Sarcomatoid transformation, capsular effraction and capsular rupture were significantly correlated with Fuhrman grade (p<0.01) and patient survival (p<0.05). CONCLUSION: The proliferation index is not a prognostic factor, but DNA ploidy appears to be more useful because of its correlation with Fuhrman grade and the level of extension of the thrombus (RV/IVC). The proliferation index and ploidy appear to be involved in the process of carcinogenesis and venous thrombus.

Aged↗