PubMed Health⌕ Search

Biomedical subjects

Philippe Michaud

Publications and source records attributed to Philippe Michaud.

7 recordsLinked to original sources

[Early detection and brief intervention to reduce excessive drinking].

The high frequency of excessive drinking among populations of western countries justifies screening strategies by primary health care givers. The intervention following the identification of a problem drinker should be adjusted according to the nature and level of alcohol-related risk or harm. A non-judgmental and benevolent dialogue about alcohol consumption is to be carried out with every patient, for in most cases this is enough to identify anyone concerned by at-risk or harmful drinking and to assess any consequences and dependence levels. Standardized questionnaires have been conceived and validated to encourage practitioners to carry out this type of interview, taking into account two contradictory needs: a systematic approach of the screening and the need for rapidity. In the same objective, among all sorts of "brief interventions" the efficient ones have been adapted to target populations and to be acceptable to the clinicians' point of view. These tools have been conceived to help excessive drinkers reduce their alcohol consumptions, but they can be a model for a more general approach to secondary prevention, considering all risk factors, not only hazardous behaviour to health.

Alcoholic Intoxication↗

["Drinking less is better". Combining early identification and brief intervention for patients at risk].

Above 210 grams a week in men and 140 grams a week in women, alcohol consumption is a risk factor for avoidable mortality in the general population. Beyond specific risk situations (for example, pregnancy, medication that interferes with alcohol, operating machinery, or a history of alcohol-dependence) in which abstinence is recommended, consumption of levels below these thresholds (which represent respectively an average of 3 and 2 drinks a day) involves little risk. Above these thresholds, the frequency of secondary disease (principally cancers and cardiovascular, neurologic, hepatologic, and gastroenterologic disorders) contributes to reducing life expectancy in drinkers. Early identification of excessive but not dependent alcohol consumption is the only means of avoiding the morbidity and mortality associated with drinking. Health providers too often confound alcoholism with alcohol-related problems. Half of the deaths associated with alcohol, however, concern people who are not dependent on it. Excessive drinkers must be identified early if they are to be counseled and helped to reduce their consumption. The brief intervention is a counseling practice easy to learn. When practiced wisely (in people who drink to excess but are not alcohol-dependent), this brief intervention takes 10 minutes and provides information, motivational and behavioral counseling. It can be learned in two evenings and is immediately transposable into daily practice. The brief intervention is effective. It leads to a reduction in consumption below the risk thresholds in 10-50% of cases. Any trained care giver in primary care, hospital, or preventive medicine can provide it. Tools for identification and intervention are available. Two screening questionnaires have been validated in French, the AUDIT (a self-administered questionnaire) and the FACE (a questionnaire completed by the doctor). The procedures and philosophy of interventions are defined and validated, and training is available for all providers who want to acquire this practice. This original research activity leads to a new public health effort. WHO, the national association for prevention of alcoholism and addiction, and various public health agencies have developed the experimental program 'Drinking less is better', intended to adapt WHO tools for early identification and brief intervention (EIBI) to French medical practice. This research-activity was conducted in close association with its targets (especially general practitioners) and has contributed to defining the conditions for the diffusion of this EIBI in France. Based on its conclusions, the health authorities have launched a national training strategy.

Alcohol Drinking↗

Fast alcohol consumption evaluation: a screening instrument adapted for French general practitioners.

BACKGROUND: To meet the needs of French general practitioners (GPs), we created a short (5 questions) interview/screening test for alcohol-related problems that is similar to AUDIT in terms of (1) test values and (2) identification of 3 groups: (a) abstainers and low-risk drinkers; (b) heavy drinkers; and (c) alcohol abusers or showing dependence. METHOD: Nine questions (from AUDIT, CAGE, TWEAK, Five-shot Questionnaire) were given systematically to their patients (aged 18 or more) by 41 volunteer GPs. Before the consultation, patients confidentially completed the AUDIT questionnaire in the waiting room. After the consultation, an addiction specialist evaluated each patient's alcohol consumption and DSM-IV criteria for alcohol abuse and dependence and these were used as gold standards. RESULTS: The analysis included 564 patient records and used stepwise logistic regression to select 7 questions, from which a second selection resulted in a 5-item questionnaire. These questions are: AUDIT questions 1 (Frequency) and 2 (Usual quantity), CAGE questions 2 (Annoyed) and 4 (Eye-opener), and TWEAK question 5 (Black-out), with each question scored 0 to 4. High levels of sensitivity and specificity were obtained for each diagnosis (sensitivity 75%-87.8%; specificity 74%-95.8%). CONCLUSION: FACE is an appropriate screening method for French general practitioners.

Adult↗

The Alcohol Use Disorders Identification Test (AUDIT) as a screening tool for excessive drinking in primary care: reliability and validity of a French version.

BACKGROUND: Excessive drinking is a major problem in Western countries. AUDIT (Alcohol Use Disorders Identification Test) is a 10-item questionnaire developed as a transcultural screening tool to detect excessive alcohol consumption and dependence in primary health care settings. OBJECTIVES: The aim of the study is to validate a French version of the Alcohol Use Disorders Identification Test (AUDIT). METHODS: We conducted a validation cross-sectional study in three French-speaking areas (Paris, Geneva and Lausanne). We examined psychometric properties of AUDIT as its internal consistency, and its capacity to correctly diagnose alcohol abuse or dependence as defined by DSM-IV and to detect hazardous drinking (defined as alcohol intake >30 g pure ethanol per day for men and >20 g of pure ethanol per day for women). We calculated sensitivity, specificity, positive and negative predictive values and Receiver Operator Characteristic curves. Finally, we compared the ability of AUDIT to accurately detect "alcohol abuse/dependence" with that of CAGE and MAST. RESULTS: 1207 patients presenting to outpatient clinics (Switzerland, n = 580) or general practitioners' (France, n = 627) successively completed CAGE, MAST and AUDIT self-administered questionnaires, and were independently interviewed by a trained addiction specialist. AUDIT showed a good capacity to discriminate dependent patients (with AUDIT > or =13 for males, sensitivity 70.1%, specificity 95.2%, PPV 85.7%, NPV 94.7% and for females sensitivity 94.7%, specificity 98.2%, PPV 100%, NPV 99.8%); and hazardous drinkers (with AUDIT > or =7, for males sensitivity 83.5%, specificity 79.9%, PPV 55.0%, NPV 82.7% and with AUDIT > or =6 for females, sensitivity 81.2%, specificity 93.7%, PPV 64.0%, NPV 72.0%). AUDIT gives better results than MAST and CAGE for detecting "Alcohol abuse/dependence" as showed on the comparative ROC curves. CONCLUSIONS: The AUDIT questionnaire remains a good screening instrument for French-speaking primary care.

Adolescent↗

Production of oligoglucuronans by enzymatic depolymerization of nascent glucuronan.

An original bioreactor process for production of oligoglucuronans was developed using the Sinorhizobium meliloti M5N1CS strain that produces glucuronan. This anionic homopolysaccharide was composed of beta-D-(1,4)-glucopyranosyluronic residues variably O-acetylated at C-3 and/or C-2 positions according to culture conditions. It was depolymerized during its biosynthesis by addition of a fungal glucuronan lyase activity in broths. After purification by tangential ultrafiltration and low-pressure liquid chromatography, (1)H NMR and ESI-Q/TOF-MS characterized the poly- and oligoglucuronic acid fractions. This enzymatic bioreactor strategy authorized the production in gram quantity of an unsaturated and no acetylated oligoglucuronan with a degree of polymerization of 3.

Biotechnology↗