Biomedical subjects

Philippe S Archambault

Publications and source records attributed to Philippe S Archambault.

5 recordsLinked to original sources

PubMed2006

The cortical network for eye-hand coordination and its relevance to understanding motor disorders of parietal patients.

Cortical neurons in both superior (SPL) and inferior (IPL) parietal lobules are modulated by a variety of signals concerning planning and execution of eye and hand movement. Thanks to these properties, parietal neurons are ideally suited for eye-hand coordination during reaching. In SPL, a fundamental feature of neurons is the invariance of their directional tuning properties across tasks that require different forms of spatial relationships between the eye and the hand. In such conditions, the orientation of the preferred directions (PDs) of individual SPL cells cluster within a limited sector of space, the global tuning field (GTF), to be regarded as an ideal frame to dynamically match eye and hand signals on the basis of the orientation of their PDs. At the population level, the mean vectors of the GTF cover the direction continuum in a uniform fashion. These neurons are part of a parietal network richly interconnected with the premotor and motor areas of the frontal lobe. Thus, the reaching disorders of patients with optic ataxia might be interpreted as a consequence of the breakdown of the combinatorial mechanisms of the GTF of parietal neurons, and of their interplay with premotor cortex. In IPL, the main feature of eye and/or hand related neurons is the uneven distribution of their PDs, that mostly point toward the contralateral space. This anisotropy of the representation of directional motor space might explain the movement disorders that characterize directional hypokinesia in neglect patients. In conclusion, the study of the dynamic properties of parietal neurons and of their relationships with the premotor cortex via cortico-cortical connections provides a basis for an interpretation of movement disorders of parietal patients from a neurophysiological perspective.

Animals↗

PubMed2005

Basic elements of arm postural control analyzed by unloading.

To address the question of how arm posture is controlled, we analyzed shoulder-elbow unloading responses in the horizontal plane for different directions of the initial load. The initial load, produced by a double-joint manipulandum, was suddenly diminished to 1of 12 randomly presented levels (60 to -10% of the initial load; in 6 out of 12 cases the final load direction varied by +/-20 degrees ). Subjects were instructed "not to intervene" in response to unloading. Neither the unloading onset nor the final load level was predictable and we assumed that the responses to rapid unloading were involuntary. Unloading elicited a smooth hand movement characterized by a bell-shaped velocity profile. The changes in hand position, joint angles, and joint torques generally increased with greater amounts of unloading. For each direction of the initial load, tonic electromyographic activity of the shoulder and elbow muscles also changed, depending on the amount of unloading. The shoulder and elbow joint torques before and after unloading were a function of the difference between the actual configuration of the arm and its referent configuration (R) described by the angles at which each joint torque was zero. The R configuration changed depending on the direction of the initial load. Our electromyographic data imply that these changes result from a central modification of muscle activation thresholds. The nervous system may thus control the R configuration in a task-specific way by leaving it unchanged to generate involuntary responses to unloading or modifying it to accommodate a new load direction at the same initial position. It is concluded that the R configuration is a major variable in both intentional and involuntary control of posture.

Adult↗

PubMed2003

Vestibular contribution to combined arm and trunk motion.

Recent studies have shown that the hand-pointing movements within arm's reach remain invariant whether the trunk is recruited or not or its motion is unexpectedly prevented. This suggests the presence of compensatory arm-trunk coordination minimizing the deflections of the hand from the intended trajectory. It has been postulated that vestibular signals elicited by the trunk motion and transmitted to the arm motor system play a major role in the compensation. One prediction of this hypothesis is that vestibular stimulation should influence arm posture and movement during reaching. It has been demonstrated that galvanic vestibular stimulation (GVS) can influence the direction of pointing movements when body motion is restrained. In the present study, we analyzed the effects of GVS on trunk-assisted pointing movements. Subjects either moved the hand to a target or maintained a steady-state posture near the target, while moving the trunk forward with the eyes closed. When GVS was applied, the final position of the hand was deviated in the lateral and sagittal direction in both tasks. This was the result of two independent effects: a deviation of the trunk trajectory and a modification of the arm position relative to the trunk. Thus, the vestibular system might be directly involved not only in the control of trunk motion but also in the arm-trunk coordination during trunk-assisted reaching movements.

Adult↗

PubMed2002

Hemispheric specialization in the co-ordination of arm and trunk movements during pointing in patients with unilateral brain damage.

During pointing movements involving trunk displacement, healthy subjects perform stereotypically, selecting a strategy in which the movement is initiated with either the hand or trunk, and where the trunk continues after the end of the hand movement. In a previous study, such temporal co-ordination was not found in patients with left-hemispheric brain lesions reaching with either their dominant paretic or with their non-dominant non-paretic arm. This co-ordination deficit may be associated in part with the presence of a lesion in the dominant left hemisphere. If so, then no deficit should be observed in patients with stroke-related damage in their non-dominant right hemisphere moving with their ipsilesional arm. To verify this, 21 right-hand dominant adults (7 who had had a stroke in the right hemisphere, 7 who had had a stroke in the left hemisphere and 7 healthy subjects) pointed to two targets located on a table in front of them in the ipsilateral and contralateral workspace. Pointing was done under three movement conditions: while not moving the trunk, while bending the trunk forward and while bending the trunk backwards. The experiment was repeated with the non-paretic arm of patients with stroke and for the right and left arms of healthy subjects. Kinematic data were recorded (Optotrak). Results showed that, compared to healthy subjects, arm-trunk timing was disrupted in patients with stroke for some conditions. As in patients with lesions in the dominant hemisphere, arm-trunk timing in those with lesions in the non-dominant hemisphere was equally more variable than movements in healthy subjects. However, patients with dominant hemisphere lesions used significantly less trunk displacement than those with non-dominant hemisphere lesions to accomplish the task. The deficit in trunk displacement was not due to problems of trunk control or sitting balance since, in control experiments, all subjects were able to move the trunk the required distance, with and without the added weight of the limb. Results support the hypothesis that the temporal co-ordination of trunk and arm recruitment during pointing movements is mediated bilaterally by each hemisphere. However, the difference in the range of trunk displacement between patients with left and right brain lesions suggests that the left (dominant) hemisphere plays a greater role than the right in the control of movements involving complex co-ordination between the arm and trunk.

Adult↗

PubMed2002

Pointing movements may be produced in different frames of reference depending on the task demand.

Movements are likely guided by the nervous system in task-specific spatial frames of reference (FRs). We tested this hypothesis by analyzing fast arm pointing movements involving the trunk made to targets located within the reach of the arm. In the first experiment, subjects pointed to a motionless target and, in the second experiment, to a target moving synchronously with the trunk. Vision of the arm and targets was prevented before movement onset. Each experiment started after three to five training trials. In randomly selected trials of both experiments, an electromagnet device unexpectedly prevented the trunk motion. When the trunk was arrested, the hand trajectory and velocity profile remained invariant in an FR associated with the experimental room in the first or in an FR moving with the trunk in the second experiment. Substantial changes in the arm interjoint coordination in response to the trunk arrest were observed in the first but not in the second experiment. The results demonstrate the ability of the nervous system to rapidly adapt behavior at the joint level to transform motor performance from a spatial FR associated with the environment to one associated with the body. A theoretical framework is suggested in which FRs are considered as pre-existing neurophysiological structures permitting switching between different FRs and guiding multiple joints and muscles without redundancy problems.

Adult↗