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Biomedical subjects

Phillip Clark

Publications and source records attributed to Phillip Clark.

7 recordsLinked to original sources
PubMed2006

Detection and identification of a novel spotted fever group rickettsia in Western Australia.

The extent to which rickettsiae are present in Western Australia (WA) is largely unknown. Recently there has been anecdotal evidence of a disease of unknown but possibly rickettsial origin occurring on Barrow Island, WA. Ticks were collected from people and screened using PCR. The rickettsial species was then cultured and its novelty and phylogenetic position examined. The infecting rickettsial species is divergent enough to be classified as a novel species. Sequence data suggest that the evolutionary route for Australian rickettsiae did not progress through a recent common ancestor. The pathogenic potential of the novel species is as yet unknown.

Evolution, Molecular↗
PubMed2006

Rickettsia felis in fleas, Western Australia.

This study is the first confirmation of Rickettsia felis in Australia. The organism was identified from 4 species of fleas obtained from dogs and cats in Western Australia, by using polymerase chain reaction amplification and DNA sequencing of the citrate synthase and outer membrane protein A genes.

Animals↗
PubMed2004

Institutionalizing interdisciplinary health professions programs in higher education: the implications of one story and two laws.

The interdisciplinary education of health professionals in the USA has increasingly been tied to renewed efforts directed toward quality improvement in the healthcare system, where problems with communication, collaboration, and cooperation are seen as endemic. Many of the published reports and recommendations on interdisciplinary programming, however, have omitted or downplayed the difficulties and challenges of developing and sustaining efforts in this area. Through the presentation of a detailed case study and the exploration of two laws of interdisciplinary programming proposed from it, this paper explores the fundamental difficulties of developing and, more importantly, sustaining interdisciplinary health professions programs in higher educational settings. The utilization of strategies based on emerging forces in the healthcare system and in higher education itself is suggested for initiating interdisciplinary projects, and structural and procedural factors are explored as critical in guaranteeing the long-term sustainability of such programs. Recommendations for the successful development and implementation of interdisciplinary programs in higher educational contexts are suggested, focusing particularly on the role of an advocate in the top down and bottom up development and maintenance of the resources needed for the success of such programs.

Curriculum↗
PubMed2002

Artifactual changes in equine blood following storage, detected using the Advia 120 hematology analyzer.

BACKGROUND: Delayed analysis of blood samples may be caused by restricted access to laboratories. Artifactual changes may occur in the measured analytes as a consequence of delayed analysis and may complicate interpretation of the data. OBJECTIVE: The purpose of this study was to characterize artifactual changes in equine blood, due to storage, using the Advia 120 hematology analyzer. METHODS: Samples of blood from 5 horses were analyzed using the Advia 120 soon after collection and again after 24 and 48 hours of storage at either 4 degrees C or ambient laboratory temperature ( approximately 24 degrees C). RESULTS: Delayed analysis of equine blood samples resulted in increased numbers of normocytic hypochromic RBCs, increased numbers of macrocytic hypochromic RBCs, misclassification of granulocytes as mononuclear cells using the basophil reagent method, and pseudothrombocytosis, due to misclassification of ghost RBCs as platelets. The latter artifact was corrected by an amended version of the software. Many of the artifactual changes were identified by morphology flags. CONCLUSIONS: Characteristic changes in cytograms produced by the Advia 120 allowed recognition of artifactual changes in stored equine blood samples. These changes were less pronounced in samples stored at 24 degrees C than at 4 degrees C.

Animals↗