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Pierre Lefèbvre

Publications and source records attributed to Pierre Lefèbvre.

4 recordsLinked to original sources
PubMed2006

Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis.

Type 2 diabetes is characterized by an approximately 60% loss of beta-cell mass, a marked defect in postprandial insulin secretion, and a failure to suppress postprandial glucagon concentrations. It is possible that postprandial hyperglucagonemia in type 2 diabetes is due to impaired postprandial insulin secretion. To address this, we studied eight adult Goettingen minipigs before and after an approximately 60% reduction in beta-cell mass induced by alloxan. Pigs were studied fasting and after ingestion of a mixed meal. Insulin and glucagon secretion were determined by deconvolution of blood hormone concentrations measured at 1-min intervals. The relationship between insulin and glucagon release was analyzed using cross-correlation and forward versus reverse cross-approximate entropy. We report that glucagon and insulin were secreted in approximately 4-min pulses. Prealloxan, postprandial insulin secretion drove an approximately 20% suppression of glucagon concentrations (P < 0.01), through inhibition of glucagon pulse mass. The alloxan-induced approximately 60% deficit in beta-cell mass lead to an approximately 70% deficit in postprandial insulin secretion and loss of the postprandial insulin-driven suppression of glucagon secretion. We conclude that postprandial hyperglucagonemia in type 2 diabetes is likely due to loss of intraislet postprandial suppression of glucagon secretion by insulin.

Animals↗
PubMed2004

The global challenge of diabetes.

Diabetes is one of the main causes of death in most developed countries. Both types of diabetes are spreading across the globe at an alarming rate, driving the condition to become one of the most challenging health problems of the 21st Century. Prevention is essential, and promoting a healthy lifestyle, early screening and investment in national programmes are key to putting the scourge of diabetes on hold. The International Diabetes Federation (IDF) plays a crucial role in the global fight against diabetes. Its objectives are to improve diagnosis, care and treatment of diabetes; promote educational and training programmes; develop insulin availability and affordability and raise awareness of the condition. The IDF hopes that these actions will not only save but also enhance the lives of people with diabetes.

Cooperative Behavior↗