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Piotr Lisowski

Publications and source records attributed to Piotr Lisowski.

9 recordsLinked to original sources
PubMed2006

[Rupture of the sinus of Valsalva aneurysm complicated by infective endocarditis -- diagnosis difficulties].

Aneurysm of the sinus of Valsalva is a rare congenital heart disease. It constitutes about 0.14%-1.5% of congenital heart surgery cases. Aneurysm of the sinus of Valsalva can be asymptomatic for many years. Only rupture of the sinus of Valsalva aneurysm leads to hemodynamic disturbances which in turn causes rapid deterioration of patient clinical condition. Some of the congenital heart diseases can be complicated by of infective endocarditis. This case report concerns the rupture of the sinus of Valsalva aneurysm in a 45 year old woman, which caused infective endocarditis on the tricuspid valve, which has been initially diagnosed as a complication of congenital heart disease in the form of the intraventricular defect.

Aortic Rupture↗
PubMed2005

[Evaluation test of cadmium concentration influence on selected lipid metabolism parameters in smokers with stable coronary artery disease scheduled for coronary artery bypass grafting (CABG)].

The influence of cadium from cigarette intoxication on selected lipid metabolism parameters in smokers with stable coronary artery disease scheduled for coronary artery bypass grafting (CABG) was studied. It has been shown that concentration of cadmium leads to an increase in the lipid peroxidation and changes in the lipid metabolism. In our study, there was a significant higher cadmium concentration in smokers with stable angina pectoris (20.90+/-0.18) compared to stable angina pectoris non-smokers (7.71 +/-0,45), p<0.0001. We have not found correlations between cadmium concentration in smokers and non-smokers with stable angina pectoris patients and total cholesterol, LDL, HDL, and triglicerydes concentrations. Total cholesterol, LDL, HDL and TG concentrations in smokers scheduled for CABG were respectively: 221.60+/-10.26 mg/dl; 148.40+/-8.71 mg/dl; 41.16+/-2.12 mg/dl, 159.10+/-14.49 mg/dl. All of these lipid parameters in stable angina pectoris smokers did not differ significantly from non-smokers.

Adult↗
PubMed2005

[Determination of ascorbic and dehydroascorbic acid concentration using HPLC method in smokers with stable coronary artery disease scheduled for coronary artery bypass grafting (CABG)].

Ascorbic acid is a vitamin soluble in water and its deficiency in human body causes scurvy. Its symptoms in adults are gingivitis, susceptibility of blood vessels to damage and bleeding, changes in bones and cartilage and retarded wound healing. Ascorbic acid is necessary in redox processes taking place in cell. It is reversibly oxidized to dehydroascorbic acid and partially metabolized to inactive sulphide and oxalic acid, which is expelled in urine. It is well absorbed from the digestive system and easily reaches the tissues. Healthy organism contains 1.5 g of ascorbic acid and daily requirement for ascorbic acid is estimated for 30-100 mg. Ascorbic acid is not synthesized by humans, but it is an essential dietary vitamin for the species. Ascorbic acid is used in treatment deficiency in daily demand for vitamin C, caused by improper diet, poor absorption or cigarette smoking. It is used in large doses in general weakness, infectious diseases and during the recovery period. Positive results have been obtained after therapy with vitamin C of Mollera-Barlowa disease, Schonlein-Henoch disease, Werlhof disease, haemophilia and also in patients with stable coronary artery disease. Vitamin C is assumed to be a basic antioxidant, although its role in pathological conditions is controversial. However, it seems that the complexity of the oxidant-antioxidant system makes the question of participation of vitamin C (and other scavengers of free radicals) in pathogenesis of diseases still open.

Adult↗
PubMed2005

[Long-term smoke-cadmium concentration in smokers seniors with stable coronary artery disease scheduled for coronary artery bypass grafting (CABG)].

Cadmium is one of the many toxic components of inhaled tobacco smoke. The amount of cadmium inhaled from each pack of 20 cigarettes is approximately 16 microg. Cadmium has a long elimination time (estimated at 10 to 30 years). It provides possible of the accumulation of substantial amounts of cadmium during the lifetime of a smoker. We know reports that cadmium alters the metabolism of cultured human smooth muscle cells and the processing of collagen. Cadmium also blocks calcium channels and inhibits ATPases, other ion transport systems. The concentration of cadmium probably has an influence on selected lipid metabolism parameters. Smoking is the most consistent risk factor for patients with stable coronary artery disease scheduled for coronary artery grafting. Cadmium was measured by atomic absorption spectrometry in humans blood from 19 seniors (patients: 70-76 years old) with stable coronary artery disease scheduled for coronary artery grafting. Total cadmium content was associated with smoking. The level of cadmium in smokers blood plasma was 19.02+/-0,96 microg/l; the level of cadmium in no-smokers blood plasma was 5.96+/-0,69 microg/l. We also measured total concentration of cholesterol, LDL, HDL, triglicerydes, creatinine and glucose.

Aged↗
PubMed2004

Influence of low molecular weight heparin preparations on human internal thoracic artery contraction.

OBJECTIVE: Low molecular weight heparins (LMWHs) offer practical and potential pharmacological advantages over unfractionated heparin in multiple applications but have not been studied as vasoactive agents. The purpose of this study was to investigate the effects of two commercial preparations of LMWHs, enoxaparin sodium and nadroparin calcium, on vasoconstriction in the human internal thoracic artery (ITA) in vitro. METHODS: Samples of redundant ITA segments obtained from 36 patients who underwent coronary artery bypass surgery were cut into 3mm wide rings and suspended in 20 ml organ bath. Activity of ITA rings precontracted with 80 mM KCl, 0.1 microM endothelin-1 (ET-1) and 1 microM norepinephrine (NE) after administration of enoxaparin and nadroparin in accumulative concentration ranging from 0.1 to 13.2 UI AXa/ml were recorded under isometric conditions by means of force transducers with digital output. The contraction after 80 mmol KCl, 0.1 microM ET-1 and 1 microM NE administration was treated as a control. RESULTS: Both studied LMWHs in concentration ranging from 0.12 to 13.2 UI AXa/ml did not change basal tonus and KCl precontracted ITA rings. When used in concentrations higher than 13.2 UI AXa/ml nadroparin but not enoxaparin significantly increased the tension in KCl precontracted arterial rings. In NE and ET-1 precontracted rings enoxaparin and nadroparin caused dose dependent relaxation without significant differences between both preparations. Incubation with nitric oxide blocker-Nomega-NITRO-L-ARGININE (L-NNA) in concentration 0.2 mM caused a significant attenuation of relaxant responses to both studied LMWHs in NE and ET-1 precontracted rings. CONCLUSION: LMWHs can have vasorelaxant effects on the receptor-mediated ITA vasoconstriction. The results suggest that LMWHs-induced relaxation in the human ITA is at least partially caused by nitric oxide release. Although the vasoactive effects are not the primary advantage of these drugs used as antithrombotics, such effects might have some clinical importance in the treatment and prophylaxis of graft spasm.

Anticoagulants↗
PubMed2004

Effects of coronary artery by-pass grafting on haemostatic factors.

BACKGROUND: Atherogenesis is triggered by functional or structural endothelial injury which leads to humoral and secretion alterations. The haemostatic system plays a significant role in the development of atherosclerosis and its complications, especially acute coronary syndromes. AIM: To assess the effects of coronary artery by-pass grafting (CABG) on some haemostatic factors in patients with stable coronary artery disease (CAD). METHODS: The study group consisted of 45 patients (11 females, 34 males, mean age 60.4+/-9.4 years, range 35-75 years). Endothelial function marker - von Willebrand factor (vWF), and thrombin generation parameters - thrombin-antithrombin complexes (TAT) and prothrombin fragments - F1+2 were measured before as well as 3 days, 7 days and 3 months after CABG. The control group consisted of 33 healthy volunteers (17 females, 16 males, mean age 48.8+/-17.2 years). RESULTS: Serum concentration of vWF as well as TAT and F1+2 levels were significantly higher in the CABG group than in controls. Compared with baseline values, the vWF levels were significantly higher 3 and 7 days after CABG. CONCLUSIONS: There is a hypercoagulability state in patients with CAD who undergo CABG. The use of extracorporeal circulation causes a significant increase in the vWF level which suggests a marked endothelial injury caused by CABG procedure.

Adult↗
PubMed2004

[Role of the hemostatic system in pathogenesis of atherosclerosis as the main etiology of coronary ischemia] [corrected].

Coronary artery disease is a leading cause of mortality in highly developed societies. This occurs in spite of growing therapeutic opportunities. Atherosclerosis begins as a functional or/and structural damage of endothelium, which in turn causes its discontinuation and impairs humoral and secreting function. Haemostasis plays an important role in the progression of atherosclerosis and development of cardiac complications--acute coronary syndromes. Research still continues to determine precisely role of each of haemostasis disorders in increased risk of coronary artery disease and its complications. The aim of this paper is to review the literature data concerning haemostatic risk factors and their role of development of coronary artery disease. Fibrinogen, thrombocytes, factor VII, factor VIII, von Willebrand factor (vWF), thrombomodulin (TM), plasminogen activator inhibitor--type 1 (PAI-1), tissue-plasminogen activator (t-PA) and other haemostatic factors, were described as more or less helpful in estimation of risk of occurrence of coronary artery disease and its cardiovascular complications. Only some of the described hematologic factors were verified so far in large prospective studies, and were recognized as independent risk factors of cardiovascular diseases.

Arteriosclerosis↗
PubMed2004

[Role of the hemostasis in unstable angina pectoris].

Haemostasis plays an important role in the development of cardiac complications--acute coronary syndromes. The thrombus formation in coronary arteries, related to unstable atherosclerotic plaque rupture is the basic pathogenesis of acute coronary syndromes. The balance between coagulation and fibrinolytic system influences on ruptured atherosclerotic plaque and following acute coronary syndrome. Critical narrow or total occlusion of the coronary artery could be a consequence of this interaction. Researches are continued to determine precisely role of haemostasis disorders in unstable angina pectoris. The aim of this paper is to review the literature data concerning haemostatic risk factors in unstable angina pectoris. Fibrinogen, thrombocytes, factor VIII, von Willebrand factor (vWF), thrombomodulin (TM), plasminogen activator inhibitor--type 1 (PAI-1), tissue-plasminogen activator (t-PA) and other haemostatic factors, play more or less essential role in unstable angina pectoris. However further investigations are needed to determine their utility and to search for new and better haemostatic factors of acute coronary syndromes.

Angina, Unstable↗